Cosmetics Raw Materials CAS 1428450-95-6 Isobutylamido Thiazolyl Resorcinol powder Thiamidol

Cosmetics Raw Materials CAS 1428450-95-6 Isobutylamido Thiazolyl Resorcinol powder Thiamidol

Thiamidol this ingredient. Also translated as "peptide Amido", chemical name: isobutylamidothiazolyl isophenone, is a new raw material introduced in recent years by Beiersdorf company (the parent company of Nivea, Euserin, Leberni). The structural formula is shown in Figure 1, No. 1. Mushroom tyrosinase is an important tool in the selection process of whitening ingredients because of its easy access to sources. However, mushroom tyrosinase and human tyrosinase are very different, and the results obtained by mushroom tyrosinase may not be applicable to humans. In order to solve this problem, Beiersdorf successfully obtained human tyrosinase using cell transfection method and screened more than 50,000 compounds, of which 630 is the best, the peptide ametol, also named LUMINOUS 630. And in the paper compared with other commonly used whitening materials.

The literature compared the inhibition of several raw materials on human tyrosinase and melanin in skin models (which more closely resemble the real situation in humans). As can be seen from the table, in human tyrosinase inhibition experiments and skin model experiments, the melanin inhibition ability of Thiamidol was far higher than that of other raw materials. The inhibitory effect of human tyrosinase is 20 times stronger than 4-butylresorcinol, 100 times stronger than 377 (phenylethylresorcinol), 500 times more than kojic acid, and more than 1,000 times arbutin. The skin model also performed very well, 15 times more than 4-butylresorcinol and 20 times more than hydroquinone.

1. Thiamidol is a highly effective whitening agent, which can be used not only for skin whitening, but also for hair, eyes and other parts. It is extracted from a variety of natural plant extracts, does not contain harmful chemicals, safe and reliable.

2. In vitro experimental studies have confirmed that Thiamidol is the strongest tyrosinase inhibitor known at present, inhibiting pigment formation from the source, thus achieving a strong whitening effect.

3. A number of clinical studies have confirmed that Thiamidol can effectively improve mild, moderate and severe melasma. Its efficacy is similar to 4% hydroquinone and superior to 2% hydroquinone. Thiamidol can also effectively improve pigmentation spots and age spots.

4. Thiamidol is non-cytotoxic, mild and non-irritating, and has great advantages over hydroquinone.

5. The use of whitening agent Thiamidol can effectively reduce the melanin in the skin and make the skin fairer and smoother. At the same time, it can also help the skin moisturize, prevent dry skin rough, is an ideal skin care product.

6. In addition to skin whitening, the whitener Thiamidol can also be used to whiten hair. It can help restore the original white hair by inhibiting the production of melanin in the hair, making the hair more bright and supple.

7. In addition, it also has an antioxidant effect, Thiamidol can effectively resist the damage of free radicals, prevent eye diseases, such as bags, dark circles and other problems. In short, Amil is an efficient and safe whitening agent that can be used on skin, hair, eyes and other parts. Its whitening effect is remarkable, moisturizing effect is good, by the majority of users love.

The most powerful whitening ingredient in the history of melanin and whitening - the Thiamidol From 2018 to 2021, Beiersdorf published three heavyweight articles, They used recombinant human tyrosinase to screen out from the library of 50,000 compounds the strongest inhibitor of human tyrosinase activity so far - isobutylamidothiazolyl-isophenone (referred to as peptide amine mitol, Thiamidol), and applied for a patent (domestic patent number is CN105007991A), known as the strongest whitening ingredient in history.