| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | 4-Hydroxyacetanilide |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| 103-90-2CAS: | 103-90-2 | Mf: | C8H9NO2 |
|---|---|---|---|
| MW: | 151.16 | Specification: | 99% |
| EINECS No.: | 203-157-5 | Appearance: | White Crystalline Powder |
| Sample: | Available | ||
| High Light: | CAS 103-90-2,99% Acetaminophen Powder,Pharmaceutical 4-Hydroxyacetanilide Powder |
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99% API Pharmaceutical APAP Acetamino phen Raw Material 4-Hydroxyacetanilide Powder CAS 103-90-2
|
Product name |
4-Hydroxyacetanilide |
|
Appearance |
White Crystalline Powder |
|
CAS |
103-90-2 |
|
MF |
C8H9NO2 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introductction of 4-Hydroxyacetanilide
4-Hydroxyacetanilide also known as Acetamino phen, which is shorted as APAP, it is the most commonly used non-anti-inflammatory antipyretic and analgesic, with antipyretic effect similar to aspirin, weaker analgesic effect, no anti-inflammatory and anti-rheumatic effect, and is the best variety of acetanilide drugs.
APAP is obtained from prismatic crystals in ethanol. Melting point 169-171℃, relative density 1.293(21/4℃). Soluble in ethanol, aceton* and hot water, insoluble in water, insoluble in petroleum ethe* and benzene. Odorless, bitter taste. Saturated aqueous solution pH 5.5-6.5.
APAPinhibits the synthesis of prostaglandins in the hypothalamic thermoregulatory center through the inhibition of cyclooxygenase and selectively inhibits the synthesis of prostaglandins, resulting in peripheral vasodilation and sweating to achieve the effect of antipyretic, the strength of its antipyretic effect is similar to that of aspirin; through the inhibition of synthesis and release of prostaglandins, etc., it increases the pain threshold and plays an analgesic role, which is a peripheral analgesic, the effect is weaker than that of aspirin, and is only effective for mild and moderate It is a peripheral analgesic, weaker than aspirin, and only effective for mild to moderate pain. It has no significant anti-inflammatory effect.
The Application & Function of 4-Hydroxyacetanilide
APAP is suitable for the relief of mild to moderate pain, such as fever, headache, arthralgia, neuralgia, migraine and dysmenorrhea caused by cold.
APAP can be used in cases of allergy, intolerance or inappropriateness to aspirin, such as patients with chickenpox, hemophilia and other bleeding disorders (including cases treated with anticoagulation), as well as peptic ulcers and gastritis. It is also necessary to apply other therapies to relieve the cause of pain or fever when necessary.
Other Name of 4-Hydroxyacetanilide:
Acetamino phen,4-Hydroxyacetanilide ,APAP, p-Hydroxyacetanilide ,APAP (Acetamino phen)
The COA of 4-Hydroxyacetanilide
| Batch No.: HNB221105 |
| Product Name: 4-Hydroxyacetanilide(Parace tamol) |
| CAS No.: 103-90-2 |
| Manufacture Date: 5th, Nov., 2022 Analysis Date: 6th, Nov., 2022 Expiry Date: 4th, Nov., 2024 |
| Storage: Store in cool&dry place, in well-closed containers. |
| Shelf life: 24 Months when properly stored. |
| ITEMS OF ANALYSIS | SPECIFICATIONS | RESULT |
| Characters | White crystalline powder, odorless | Complies |
| Melting Point | 168-172°C | 170°C |
| PH | 5.5-6.5 | 6.0 |
| Identification |
(1) (2)Should present positive reaction (3)The infrared absorption spectrum is consistent with the control spectrum |
Complies |
|
Ethanol solution clarity And color |
Clear, colorless and No deeper than the control solution | Complies |
| Chloride | ≤ 0.01% | 0.006% |
| Sulphate | ≤ 0.02% | 0.015% |
| p-Aminophenol and related substance |
p-Aminophenol ≤ 0.005% Other impurities ≤ 0.1% Total impurities ≤ 0.5% |
0.0003% 0.075% 0.096% |
| p-Chloroacetanilide | ≤ 0.005% | Negative |
| Loss on drying | ≤ 0.5% | 0.08% |
| Residue on ignition | ≤ 0.1% | 0.036% |
| Heavy metals | ≤ 10ppm | Complies |
| Assay | 98.0~102.0% | 99.5% |
| Conclusion | Complies with the USP43 standard | |