CAS: | 26016-99-9 | Mf: | C3H5Na2O4P |
---|---|---|---|
MW: | 182.023 | Specification: | ≥99% |
Einecs No.: | 247-409-2 | Appearance: | White Powder |
Whatsapp: | +86 15202961574 |
Veterinary API CAS 26016-99-9 Fosfomycin disodium salt Fosfomycin Sodium
Fosfomycin sodium is a broad-spectrum antibiotic used in the treatment of respiratory tract infections, urinary tract infections, skin and soft tissue infections, etc.
Fosfomycin sodium is a new antibiotic that has been emerging in recent years, mainly for the sensitive urinary system, as well as respiratory and skin bacteria. Its biggest advantage is that it has almost no drug-resistant bacteria, the main reason is that its mechanism of action is relatively new, and it is a relatively new antibiotic. It has a very wide range of applications in urology, especially suitable for the treatment of common infections of the urinary system, including infections of the male genitalia, such as prostatitis. Fosfomycin has done a good clinical experiment, confirmed that it can have a strong killing effect on common urinary bacteria, and the drug resistance rate is relatively the lowest one.
In clinical treatment, most of us are a powder, it is a small glass bottle, the instructions are recommended that you empty stomach, but if you empty stomach, the side effects of the digestive tract will be relatively more.
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Introductction of Fosfomycin Sodium:
At room temperature, it is a white crystalline powder with moisture absorption, easily soluble in water and exothermic when dissolved. Fosfomycin sodium can combine with a bacterial cell wall synthetase, blocking the first step of cell wall synthesis by bacteria using the material concerned, so as to play a bactericidal role. It has antibacterial effect on Staphylococcus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Proteus mirabilis, Bacillus typhimurium, Serratia, most pseudomonas aeruginosa, Streptococcus pyogenes, Streptococcus faecalis, some indole positive proteus, some Chemicalbook Klebsiella and Enterobacter bacteria. Fosfomycin sodium is mainly used in the treatment of sensitive Gram-negative bacteria caused by urinary tract, urinary system, skin and soft tissue, respiratory tract, intestinal tract and other sites of infection. It can also be used in combination with other antibiotics to treat severe infections caused by sensitive bacteria, such as sepsis, pulmonary, meningeal infections, peritonitis, uterine adnexitis, intrauterine infections, pelvic inflammatory disease, osteomyelitis, etc. It can also be combined with vancomycin to treat methicillin-resistant Staphylococcus aureus (MRSA) infections.
Function of Fosfomycin Sodium:
It is mainly used for the treatment of acute and chronic intestinal diseases caused by Staphylococcus, Streptococcus, Escherichia coli, Salmonella and other Gram-negative bacteria in chickens, ducks and pigs.
Fosfomycin Sodium Pharmacological action
1. Wide antibacterial spectrum, high bioavailability, fast absorption, strong antibacterial force, not affected by diet. It can kill both gram-positive and negative bacteria, especially against pseudomonas aeruginosa, Proteus, Salmonella and staphylococcus and Escherichia coli that are resistant to various drugs. Used in animals, no drug resistance and cross resistance, clinical treatment effect is good.
2. Fast bactericide: This product is a fast bactericide, and its effect is obvious after 1-Chemicalbook2 hours. About 25% of E. coli were killed 1 hour after exposure to fosfomycin (12.5μg/ml), and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were all killed at 4 and 8 hours, respectively.
3. Low toxicity and side effects, small stimulation to the body, no acute toxicity and adverse reactions, will not increase the burden on the kidney.
4. Low residue: The elimination time to reach the residue standard in muscles and organs is 48-72 hours.
COA of Fosfomycin Sodium:
CAS number | 26016-99-9 | Product Name | Fosfomycin Sodium |
Manufacture Date: | 20th Jan,2022 | Analysis Date: | 21th Jan, 2022 |
Batch NO.: | HNB220120-1 | Expiry Date: | 19th Jan, 2024 |
Storage: | Store in cool&dry place, in well-closed containers. | ||
Shelf life: | 24 Months when properly stored. |
ITEMS | SPECIFICATIONS | RESULT |
Appearance | White powder | Complies |
Assay(HPLC) | ≥99% | Complies |
Solubility | Very soluble in water,insoluble in ace,chloroform,et | Complies |
Identification | A:B:C the positive reaction | Complies |
Specific rotation | +53.5° ~ +59° | +58.0° |
PH | 5.0 ~ 7.5 | 6.7 |
Impurity A | ≤ 0.2% | Complies |
Impurity C | 3%~15% | Complies |
Any other impurity | Not more than area of the principal peak in the chromatogram obtained with RS(B)5% | Complies |
Total other impurity |
Not more than 3times the area of the principal peak in the Chromatogram obtained with RS(B)15% |
Complies |
Loss on drying | ≤8.0% | 5.0% |
Sulphate | 27.0 ~ 31.0% | 28.4% |
Sulphate ash | ≤1.0% | 0.2% |
Microcount limit test | ≤500col/g | Complies |
yeast and molds | ≤10col/g | Complies |
Escherichia coil | Absent | Complies |
Psuedo monas | Absent | Complies |
Conclusion | Meet with the USP standard |
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