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CAS 70288-86-7 Ivermectin Veterinary API Antiparasitic Insecticide

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Ivermectin
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 70288-86-7 Mf: C48H74O14
MW: 875.09 Specification: 98%-99%
Einecs No.: 274-536-0 Appearance: White Or Yellowish-white Crystalline Powder
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Insecticide Ivermectin Veterinary API


Veterinary API Antiparasitic Insecticide


70288-86-7 Dog Antiparasitic Drugs

Product Description

CAS: 70288-86-7 Veterinary API Antiparasitic Insecticide Ivermectin powder

CAS 70288-86-7 Ivermectin Veterinary API Antiparasitic Insecticide 0

Product Name Ivermectin
CAS 70288-86-7
Molecular formula C48H74O14
Molecular weight 875.09300
Grade Pharmaceutical Grade
Color White powder
Purity 99%
Shelf life 2 years


The Introductction of Ivermectin:


Ivermectin is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod,
canine intestinal nematodes, ear mites, scabies mites, silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry. This product belong to the broad-spectrum resistant parasites.
Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role; For dish tail filarial microfilariae
effectively, but for adult worms; For only in intestinal fecal round worms are also effective.
Ivermectin has the selective inhibitory effect, with no spinal nerve cells and muscle cells in the animal glutamic acid chlorine ion channels of the valve is the high binding affinity, leading to the proliferation of the chloride ion permeability of cell membrane, cause nerve cells or muscle cells hyperpolarization, parasites paralysis or death.


The Application & Function of Ivermectin:


1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.
2. Ivermectin has effect for most of the various life cycle nematodes.
3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.
5. Ivermectin has selective inhibition.
6. Ivermectin can not go through the blood brain barrier of humanbeings.


In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.

It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.

Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.

Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.




The COA of Ivermectin:


Tests Specification Results
Appearance White or yellowish-white crystalline powder, slightly hygroscopic. Yellowish-white crystalline powder, slight hygroscopic.
Solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol. Qualified
Identification IR Corresponds to that of CRS standard Qualified
HPLC The retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparation Qualified
Appearance of solution Clear and not more intensely colored than BY? Clear
Specific optical rotation (anhydrous and solvent-free substance), ° -20--17 -17.9
Related substances (%) Individual impurity(RRT 1.3-1.5)≤2.5 I-l:<0.05 K:2.1
Any other impurity ≤ 1 C:0.06 A:0.57
J:0.14 H:0.39 D:<0.05 F:<0.05
E:0.36 1-2:0.19
Total ≤5 3.8
Disregard limit: 0.05
Ethanol and Formamide (%) Ethanol ≤5.0 3.9
Formamide≤3.0 2.5
Catalyst (ug/g) ≤1 <1
Water (%) ≤1.0 0.26
Sulphated ash (%) ≤0.1 0.07
Heavy Metal (%) ≤0.002 <0.002
Assay (%) (HPLC, on dry basis) H2Bla/(H2Bla +H2Blb)≥90.0 97.7
95.0≤H2Bla +H2Blb≤ 102.0 96.7
Conclusion Complies with the requirements of EP10.0

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