Veterinary API cas 14698-29-4 oxolinic acid

Veterinary API cas 14698-29-4 oxolinic acid

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Oxolinic acid, chemical formula (molecular formula) :C13H11NO5, is a solid, at 25ºC<1.0% solubility, water solubility 0.003mg/L, is a quinolinone fungicide, used in the treatment of rice seeds, known as rice refractory bacterial disease (seedling rot) with outstanding effect of the first fungicide

What is Oxolinic acid ?

Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s. Dosages 12-20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.

Application of Oxolinic acid
Oxolinic acid belongs to the first generation of quinolones, and its mechanism of action is to inhibit the synthesis of bacterial deoxynucleotides. It has strong antibacterial effect on gram-negative bacteria, but no antibacterial effect on fungi and mycobacterium tuberculosis. The MIC50 was 0.02 ~ 0.09 g/ml. Carps were given oral infusion of 5mg/kg, 10mg/kg, 20mg/kg and 40mg/kg for a single time. After 15-24h, the blood concentration peaked, and the blood concentration maintained above 0.2 g/ml for 66h. The toxicity of this product is very small, acute toxicity test for carp oral LD50 is more than 4000mg/kg.

Oxaquinic acid, also known as oxycyclooxaquinic acid, ocisoline acid and olinic acid, is a second-generation quinolinone fungicide. It is white with yellow and white columnar crystal or crystalline powder at room temperature, odorless and tasteless. It has strong antibacterial effect on Gram-negative bacteria and part of positive bacteria, and has no cross-resistance with antibiotics, but has no antibacterial effect on fungi and tuberculosis bacilli, and has low dosage. It is mainly used for the treatment of bacterial diseases of fish and shrimp. Aquaculturists believe that it is one of the ideal drugs for the treatment of aquatic animal diseases, and has quite strong antibacterial activity against fish pathogens such as Vibrio eel and aeromonas hydrophila. Therefore, it is widely used in Japan's Chemicalbook, Taiwan Province's eel and other aquatic animals, and PH has a slight influence on it in mariculture, and the dosage needs to be increased in alkaline environment. The toxicity of oxaquic acid is minimal, acute, toxicity test for carp oral lethal dose (that is, under the influence of a certain concentration of the drug can make 50% individual death time) is more than 4000mg/kg. The use of the drug must be stopped 25 days before the use, otherwise the residual amount exceeds the limit, the Japanese market banned imports, Taiwan added Oxolinicacid (Oxolinicacid) in fish, shrimp, eggs, cattle, pigs, chickens muscle, fat, liver and kidney and other 13 residual tolerance