High Quality Veterinary Grade 99% API Triclabendazole Anthelmintic Powder CAS 68786-66-3

High Quality Veterinary Grade 99% API Triclabendazole Anthelmintic Powder CAS 68786-66-3

The Introductction of Triclabendazole

Triclabendazole is a white, odorless, tasteless powder, insoluble in water (only 0.2 mmol/L), soluble in methanol, the volatilization pressure at 20 ℃ is 1.73 × 10 11 Kp A. The volatilization pressure of Triclabendazole is 1.73 × 10 11 Kp A. The volatilization pressure of Triclabendazole is 0.5 mmol/L.

Triclabendazole belongs to the benzimidazole class of drugs, specializing in anti-flake trematode, various days of age of liver flake trematode have obvious effect of killing, it is the more desirable drug to kill liver flake trematode. After absorption, the drug interferes with the microtubule structure and function of the worm, as well as inhibits the release of hydrolyzed protease from the worm, but does not affect the ATPase related to the surface membrane of the parasite. Triclabendazole's effect on the body of the worm varies according to the concentration, such as adult worms in the low concentration (1-3μg/ml) of the drug is still alive for 24 hours, higher concentration (10-25μg/ml) in 24 hours, the activity of the activity is significantly weakened; 25-50μg/ml high concentration for 24 hours, all the inhibition. However, it is more sensitive to child worms. At a concentration of l0μg/ml, all activities were inhibited for 24 hours.

Triclabendazole bioavailability is high, goats and sheep internal l0mg/kg body weight dose after internal administration, 24 ~ 36 hours after the drug peak blood drug up to 15μg / ml, Triclabendazole and its metabolite peak blood drug for other benzimidazole anthelmintic 5 ~ 20 times, half-life of about 22 hours. Triclabendazole is mostly oxidized to sulfone and sulfoxide derivatives in sheep and rats, and these derivatives bind to albumin and persist in plasma for more than 7 days. High plasma concentrations and binding to plasma albumin appear to be associated with prolonged duration of action of antiplatelet trematode drugs. After 10 days of dosing in sheep, approximately 95% of the drug is excreted in the feces, 2% is excreted in the urine, and less than 1% is excreted in milk.

The Application & Function of Triclabendazole

Triclabendazole has been widely used in countries all over the world, and it has excellent effect on liver flake trematode in cattle, sheep, goats and other ruminants.

1. Sheep: In the low dose of Triclabendazole (even as low as 2.5mg/kg), the effectiveness of Triclabendazole on 12-week-old adult worms of sheep reaches 98%-100%, 5mg/kg on 10-week-old adult worms, 10mg/kg on 6-8-week-old worms, 12.5mg/kg on 1-4-week-old immature worms, and 15mg/kg on 1-day-old worms, the effectiveness of Triclabendazole on cattle is close to 100%.

2. Cattle: Triclabendazole is similar to sheep in killing liver flake trematode, 6mg/kg is 95%~99.5% effective against 8-14 weeks old adult trematode, 12mg/kg is 79%, 87% and 99.4% effective against 2 weeks old, 4 weeks old and 8 weeks old trematode, respectively. 12mg/kg is similar to liver flake trematode in killing adult bovine large flake trematode.

3. Others: 10mg/kg against deer liver fluke, large fluke, 12mg/kg against horse liver fluke also has good effect.

Cautions
1. doramectin is not stable, it is rapidly decomposed and inactivated by sunlight, and its residues are toxic to fish and aquatic organisms, so pay attention to the protection of water sources.
2. Pouring agent: after application to cattle, it should not be rained on within 6 hours.
3. Use with caution in dogs.
4. Keep this product out of reach of children, operators should not eat or smoke when using this product, and should wash their hands after operation.
5. The residual drug is toxic to fish and aquatic organisms, care should be taken to protect water resources.
6. The resting period is 35 days for cattle and 24 days for pigs.

Other Name of Triclabendazole

FASINEX
CGA-89317
TRICLABENDAZOLE
Triclabendazole
Tricalbendazole
Trichlobendazole
6-chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole
6-CHLORO-5-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-BENZIMIDAZOLE
5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-1H-BENZIMIDAZOLE
5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1h-benzimidazol
6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzoimidazole
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-benzimidazole
5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole, CGA-89317, Fasinex

The COA of Triclabendazole

Competitive Advantages

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FAQ

1.Can I get samples for testing?

Yes,sample can be provided,but you will need to pay the freight.