99% Antiepileptics TPM Raw Material Topiramate Powder CAS 97240-79-4

99% Antiepileptics TPM Raw Material Topiramate Powder CAS 97240-79-4

The Introductction of Topiramate

Topiramate (abbreviated as TPM) is a natural monosaccharide allantoic dextrose sulfide, which is a broad-spectrum antiepileptic drug with felbamate, lamotrigine and aminoglutethimide with more clinical applications in China, and can be used to control different types of epilepsy with good efficacy and pharmacokinetics, but it can cause cognitive impairment and neurotoxicity in children and rapid dosing, and is prone to promote kidney stones. Its basic structure is pyranofructose sulfamate, which is different from other antiepileptic drugs.

Topiramate(TPM) has multiple antiepileptic mechanisms, blocking voltage-dependent sodium channels, enhancing GABA activity at γ-aminobutyric acid A (GABAA) receptors, blocking glutamate AMPA receptor activity, in addition to mild carbonic anhydrase inhibitor effects.

The results of double-blind, placebo-controlled studies in Europe and the United States have confirmed that topiramate add-on therapy is efficacious and safe in many types of refractory epilepsy and is well tolerated. Topiramate monotherapy has now been initiated and has also achieved good efficacy, with 62% of patients experiencing complete disappearance of seizures.

Topiramate is a white crystalline powder with a bitter taste. It is very soluble in alkaline solutions with a pH of 9-10 such as sodium hydroxide or sodium phosphate, and is readily soluble in aceton*, chloroform, dimethyl sulfoxide and ethanol. The solubility in water is 9.8 mg/mL, and the pH of its saturated solution is 6.3.

The Application & Function of Topiramate

Topiramate is generally used as an adjunct to antiepileptic drugs and is effective for simple and complex seizures with generalized tonic clonic seizures, as well as for the treatment of infantile spasms. Topiramate is characterized by good long-term efficacy, no significant drug resistance, and antiepileptic at high doses when used alone.

The primary mechanism of action of Topiramate is to block the spread of epileptic seizures rather than to prevent them, and TPM has been found to exert its antiepileptic effects through a variety of mechanisms, including:
1, blocking voltage-dependent sodium channels thereby reducing the duration of epileptic discharges and the number of action potentials generated per discharge.
2, Antagonism of erythropoietin/AMPA - glutamate receptors.
3, Enhances GABA activity at the non-benzodiazepine port site of the GABA receptor.
4, Mildly inhibits carbonic anhydrase.
5, Blocks T-type calcium channels.
6, Blocking excitatory central neurotransmitter glutamate AMPA receptor activity.

Recent studies suggest that blockade of L-type high-voltage dependent calcium channels may be one of the most important mechanisms of action of topiramate against epilepsy.

Other Name of Topiramate:

TMP

Topina
Topimax
Topamax
Tracrium
topiramate
Topiramic acid

The COA of Topiramate

Product Name: Topiramate

Batch Number: HNB 20230312

Batch Quantity: 100kg

Manufacture Date: Mar.,12^th,2023      Analysis Date: Mar.,12^th,2023             Expiry Date: Mar.,11^th,2025

Storage Store in cool & dry place. Store in well-closed containers.

Shelf life: 2 years when properly stored.