Send Message

Anti Allergy Raw Material Powder 99% Loratadine Powder CAS 79794-75-5

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Loratadine
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 79794-75-5 Mf: C17H22ClNO
MW: 291.82 Specification: 99%
Grade: Medicine Grade Appearance: White Crystalline Powder
Sample: Available
High Light:

99% Loratadine Powder


Anti Allergy Loratadine Powder


API Pharmaceutical 79794-75-5

Product Description


CAS 79794-75-5 Anti Allergy Raw Material Powder 99% Loratadine Powder

Anti Allergy Raw Material Powder 99% Loratadine Powder CAS 79794-75-5 0

Product name



White crystalline powder








Keep in cool dry place.

Anti Allergy Raw Material Powder 99% Loratadine Powder CAS 79794-75-5 1


The Introductction of Loratadine


Loratadine is a commonly used anti-allergic drug, a second-generation long-acting tricyclic antihistamine, with fast onset of action and strong effect, does not contain hormones, and is metabolized to the more active desloratadine after human absorption, which inhibits histamine-induced allergic symptoms through competitive inhibition of histamine H1 receptors, without obvious anticholinergic and central inhibitory effects.

Loratadine is well absorbed orally, metabolized rapidly and extensively in the liver, and eliminated via urine and feces. It has a rapid onset of action, with some patients showing effects within 30 min, a tmax of 1.5-2 h, and an elimination half-life of 8-14 h. The active metabolite, descarboxymethoxy loratadine (DCL), has a half-life of 17-24 h. The half-life may be longer in the elderly and in patients with liver disease. The binding rate of loratadine to plasma proteins is 97% to 99%, and 73% to 76% for DCL. About 27% of loratadine is excreted in the urine after 24h of administration, about 40% is eliminated in the urine after 10 days, and 42% is excreted in the stool. Little is secreted with milk, so the drug is safe for use during lactation.


The Application & Function of Loratadine


Loratadine is used clinically to relieve symptoms associated with allergic rhinitis, such as sneezing, runny and itchy nose as well as itching and burning sensation of the eyes.


Loratadine is also used to relieve the symptoms of chronic urticaria and other allergic skin diseases.


Toxicology: No mutagenic, non-teratogenic effects in animal testing.

Common adverse reactions include headache, drowsiness, fatigue, dry mouth and blurred vision, decreased or increased blood pressure, palpitations, syncope, hyperkinesia, altered liver function, jaundice, hepatitis, hepatic necrosis, alopecia, seizures, breast enlargement, erythema multiforme, and systemic allergic reactions.


Drug interactions: Drugs that inhibit the function of hepatic drug metabolizing enzymes can slow down the metabolism of this product, such as itraconazole, ketoconazole, and 400 mg of ketoconazole taken together daily can increase the plasma concentration of this product and its active metabolite, descarboxyethylchloratadine, but no electrocardiographic changes were observed. The metabolism of loratadine can also be inhibited by administration with macrolide antibiotics, cimetidine, theophylline, etc.


Other Name of Loratadine:


ethyl 4-(8-chloro-5,6-dihydro-11h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
4-(8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptene-5-ylidene)piperidine-1-carboxylic acid ethyl ester
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine-11-ylidene)piperidine-1-carboxylic acid ethyl ester


The COA of Loratadine


Product Name Loratadine Batch No. HNB-230202
Quantity 1000kg Test Sample 10g
Manuf.Date 2023.02.02 Test Date 2023.02.02
Issuing Date 2023.02.02 Expiry Date 2025.02.01
Test items Test Iimit Results
Appearance White Powder Conforms
Identification Infrared spectrum should conform Conforms
  B. should conform Conforms
Assay(Dry base) 95.0%-101.0% 99.6%
Sieve analysis 100% pase Conforms
Cd ≤0.5ppm Conforms
Pb ≤0.5ppm Conforms
Arsenic(As) ≤0.5ppm Conforms
Heavy metals ≤10ppm Conforms
Residual Solvents < 100ppm Conforms
Residual Pesticide Negative Conforms
Loss on drying ≤1.0% 0.12%
Residue on ignition ≤1.0% 0.09%
Microbiological Tests Total plate count: ≤1000cfu/g Conforms
Moulds and Yeasts: ≤100cfu/g Conforms
Salmonella: Negative Conforms
E.coliform: Negative Conforms
Conclusion The above material complies with USP32 standard

Contact Details
Beryl Jia

Phone Number : +8618092068319

WhatsApp : +8618629242069