| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Artesunate |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 88495-63-0 | Mf: | C19H28O8 |
|---|---|---|---|
| MW: | 384.42 | Specification: | 99% |
| EINECS: | 618-170-5 | Appearance: | White Crystalline Powder |
| Sample: | Available | ||
| High Light: | API Pharmaceutical 88495-63-0,99% Artesunate Powder,Antimalarials Raw Material Artesunate Powder |
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CAS 88495-63-0 Antimalarials Raw Material 99% Artesunate Powder
|
Product name |
Artesunate |
|
Appearance |
White crystalline powder |
|
CAS |
88495-63-0 |
|
MF |
C19H28O8 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introduction of Artesunate
Artesunate is made from the active ingredient artemisinin, which is extracted from the unique Chinese Artemisia herb, and then chemically synthesized to act mainly on the asexual body of Plasmodium vivax red end stage.
Artesunate is a commonly used antiparasitic drug, a derivative of reduced artemisinin succinate monoester with sesquiterpene lactone structure, which is more potent than artemisinin against Plasmodium and also effective against antichloroquine strains. Artesunate acts on Plasmodium falciparum erythrointernal stage lysosomes, inhibiting cytochrome oxidase by reducing artemisinin, and achieving the function of inhibiting cytochrome oxidase of Plasmodium superficial membrane a food vesicle membrane and mitochondrial membrane system, thus blocking the supply of host cell plasma as nutrition. It has a strong killing effect on the asexual body of Plasmodium, and is effective in controlling malaria attacks rapidly, and has good effect on cerebral malaria, falciparum malaria and intermittent malaria, and is also effective on chloroquine-resistant strains of falciparum malaria. It is particularly effective against cerebral malaria, which can rapidly control malaria attacks, but is ineffective against gametes of P. falciparum.
The mechanism of action of artesunate is that artemisinin acts first on the food vesicle membrane, epithelium, and mitochondria of Plasmodium. This is followed by the nuclear membrane, endoplasmic reticulum, and, in addition, some effect on the chromatin in the nucleus. Since artesunate acts on the food vesicle membrane first, it blocks the nutrient uptake. It makes Plasmodium starve of amino acids sooner. Rapid formation of autophagic vesicles. And continuously excreted out of the body. A large amount of cytoplasm is lost and death occurs.
The Application & function of Artesunate
Artesunate can kill Plasmodium in the intraerythrocytic stage and achieve antimalarial effect, thus it can be used for all kinds of malaria patients, especially for the rescue treatment of patients with chloroquine- and piperaquine resistant falciparum malaria and aggressive cerebral malaria, with high antimalarial activity, fast fever reduction, short protozoal transfer time and low toxic side effects. It is the drug of choice for the treatment of severe malaria.
Artesunate is effective against parasites, such as liver flukes, and has also shown cytotoxic effects against different types of tumor cell lines.
Artesunate acts on the electron transport chain, generating local reactive oxygen species and causing depolarization of mitochondrial membranes. It inhibits TNF-induced production of pro-inflammatory cytokines by inhibiting NF-κB and PI3 kinase/Akt signaling pathways in human rheumatoid arthritis fibroblast-like synoviocytes.
Other Name of Artesunate
Artesunate
ARTESUNATE
ARTENSUNATE
Arteannuinum
Artesunic Acid
ArtesunateC19H28O8
Arteannuinum succinate
Artemisinin monosuccinate
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
4-oxo-4-{[(5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
Butanedioic Acid Mono(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] Ester
Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester
Artesunate (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
The COA of Artesunate
| Product Name | Artesunate | ||
| CAS No. | 738-70-5 | ||
| Batch No. | HNB20230223 | Manufacture Date | Feb.-23-2023 |
| Batch Size | 25kg/drum | Analysis Date | Feb.-24-2023 |
| Quantity | 100kg | Expiry Date | Feb.-22-2025 |
| Storage | Store in cool & dry place, in well-closed containers. | ||
| Shelf Life | 24 Months when properly stored. | ||
| Reference | USP41 | ||
| ITEMS OF ANALYSIS | SPECIFICATIONS | RESULT |
| Appearance | White crystalline powder | Complies |
| Identification | ||
|
A: Infrared Absorption |
Conforms to standard | Complies |
| Test | ||
| Solubility | Soluble in ethanol, aceton* or dichloromethane, very slightly soluble in water. | Complies |
| Specific Rotation | +4.5° to +6.5° | +6.2° |
| pH | 3.5～4.5 | 4.2 |
|
Chloride |
≤0.02% | Complies |
| Heavy metals | ≤20ppm | Complies |
| Loss on drying | ≤0.5% | 0.2% |
| Residue on ignition | ≤0.1% | 0.02% |
| Bacterial endotoxins | The amount of endotoxin contained in each 1mg of artesunate should be less than 1.25EU | Complies |
| Sterility | Conforms to standard | Complies |
| Related substances(HPLC) | ||
| Single impurity | ≤0.2% | 0.02% |
| Total impurities | ≤2.0% | 0.3% |
| Assay(% on dry basis) | 98.0%-102.0% | 99.6% |
| Conclusion: Complies with the USP 41 standard | ||