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64-86-8 API Pharmaceutical Grade 99% Colchicine Powder Gout Suppressants

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Colchicine
Minimum Order Quantity: 10G
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 64-86-8 Mf: C22H25NO6
MW: 399.44 Specification: 99%
EINECS No.: 200-598-5 Appearance: Light Yellow Crystalline Powder
Sample: Available
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Pharmaceutical Colchicine Powder

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Colchicine Gout Suppressants

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API 99% Colchicine Powder


Product Description

64-86-8 Gout Suppressants API Pharmaceutical Grade 99% Colchicine Powder

64-86-8 API Pharmaceutical Grade 99% Colchicine Powder Gout Suppressants 0

Product name

Colchicine

Appearance

Light Yellow Crystalline Powder

CAS

64-86-8

MF

C9H9Cl2N5S

Purity

99%

Storage

Keep in cool dry place.

64-86-8 API Pharmaceutical Grade 99% Colchicine Powder Gout Suppressants 1

 

The Introductction of Colchicine

 

Colchicine, an alkaloid extracted from the bulbs and seeds of Colchicum, a plant of the lily family, is naturally present in the lily family Garlandia and Lijiang Mountain Cichlid, with contents of 0.11% and 0.1%, respectively. Light yellow needle-like crystals. Slightly smelly, bitter taste. Melting point 157℃, easily soluble in cold water, alcohol, chloroform and formaldehyde, poorly soluble in hot water, not easily soluble in benzene and ether, almost insoluble in petroleum ether. pH of 0.5% solution is 5.9, and the toxicity can be reduced after hydrolysis by ammonia.


Colchicine inhibits mitosis, destroys spindle, and causes chromosomes to stagnate at mid-division. This abnormal division caused by colchicine is called colchicine mitosis. In such mitosis, although the chromosomes divide longitudinally, the cell does not divide and cannot form two daughter cells, thus doubling the chromosomes. Therefore, colchicine has mitosis-inhibiting and antitumor effects.

 

The Application & Function of Colchicine

 

Tizanidine hydrochloride is used for the treatment of skeletal muscle hypertonia, myospasm and myotonia due to traumatic brain and spinal cord injury, cerebral hemorrhage, encephalitis, and multiple sclerosis.

 

Toxic side effects
When tizanidine hydrochloride tablets are applied at the recommended low dose to relieve painful myospasm, adverse effects are rare and include drowsiness, fatigue, dizziness, dry mouth, nausea, gastrointestinal disturbances, and a mild decrease in blood pressure, usually mild and transient. These adverse reactions, mainly drowsiness, dry mouth, and dizziness, are more common and pronounced when applying the recommended high dose of tizanidine hydrochloride tablets for the treatment of central myasthenia gravis, although they are rarely severe enough to warrant discontinuation of therapy.

 

Other Name of Colchicine:  

AB-021;Gibonz;Zanpeak;TERNELIN;SIRDALUD;ZANAFLEX;Enchinin;Astonelin;DS-103-282;TIZANIDINE HCL

 

The COA of Colchicine

 

 

Product Name Colchicine Manufacturing Date 2022.07.15
Batch No. HNB20220715 Test Date 2022.07.15
Quantity 5KG Expiry Date 2027.9.14
 

 

Test Items Specification Results
Description Pale yellow to pale greenish-yellow, amorphous scales powder or crystalline powder. odorless or nearly so and darkens on exposure to light. Pale yellow, odorless crystalline powder. Darkens on exposure to light.
Solubility Soluble in water, freely soluble in alcohol and in chloroform, slightly soluble in ether. Complies
Identification (By IR) IR spectra should match with that of reference standard. Complies
Specific Optical Rotation Between (-)240°and (-)250°(On anhydrous and solvent free basis) (-)245.03°
Water Content (By KF) NMT 2.0% 0.58%
Limit of Colchiceine No definite green color should produce Complies
Limit of Ethyl acetate Not more than 8.0% 5.7%

Chromatographic Purity

Sum of all peaks other than colchicine peak

Not more than 5.0% 1.75%

Residual Solvents

Methanol

Hexane

Chloroform

Acetone

MDC

NMT 3000 ppm

NMT 290 ppm

NMT 60 ppm

NMT 5000 ppm

NMT 600 ppm

Complies

Complies

Complies

Complies

Complies

Assay (By HPLC) Between 94.0% and 101.0% (On anhydrous and solvent free basis) 99.55%
Conclusion The product complies as per above specification
Storage Cool dry place, protected from light and moisture.
 

Contact Details
Beryl Jia

Phone Number : +8618092068319

WhatsApp : +8618629242069