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CAS 144689-63-4 Hypoglycemic Drugs Olmesartan Medoxomil

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO, SGS
Model Number: Chlorpheniramine Maleate
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Carton Box or Drum
Delivery Time: Usually7-10days
Payment Terms: L/C, D/P, D/A, T/T, Western Union, MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 144689-63-4 Mf: C29H30N6O6
MW: 446.5 Einecs: 646-413-5
Specification: 98% Certificate: GMP/ISO9001
High Light:

CAS 144689-63-4 Hypoglycemic Drugs

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Hypoglycemic Drugs Olmesartan Medoxomil

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CAS 144689-63-4 active pharmaceutical intermediates


Product Description

CAS 144689-63-4 Pharmaceutical Intermediates Hypoglycemic Drugs Olmesartan Medoxomil

CAS 144689-63-4 Hypoglycemic Drugs Olmesartan Medoxomil 0

 

Product Name:

Olmesartan Medoxomil

Synonyms:

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl] 4-yl)methyl)-4-(;OlMesartan MedoxoMil SynoyM:4-(1-Hydroxy-1-Methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-iMidazole-5-carboxylic acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester;OLMESARTAN MEDOXOMIL USP ORGANIC CHEMICA;OMST;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;Olmesartan medoxomil for system suitability;Olmesartan MedoxomiI;Olmesartan Medoxomi

CAS:

144689-63-4

MF:

C29H30N6O6

MW:

558.59

EINECS:

604-433-1

Product Categories:

Cardiovascular APIs;OMNICEF;Aromatics;Bases & Related Reagents;Inhibitor;API;Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Olmesartan

 

The Introductction of Olmesartan Medoxomil

Olmesartan Medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion.

Olmesartan Medoxomil is a pro-drug that is de-esterified to the active metabolite, olmesartan. Olmesartan has a dual method of elimination, with about 60% eliminated by the liver and the remainder by the kidney. In situations of impaired renal or hepatic function, the alternative excretion pathway can compensate for the compromised one. Olmesartan is not metabolized by the cytochrome P450 enzyme system and therefore has a low potential for metabolic drug interactions, a feature that may be of importance when treating patients on multiple drug regimens, such as the elderly. Olmesartan is well tolerated and has an excellent safety profile that is comparable to that of placebo. In addition, olmesartan provides 24-h blood pressure control with a once-daily dosing. In head-to-head studies, olmesartan delivered superior blood pressure reduction when compared with other angiotensin-II receptor antagonists at their recommended doses.

The Function&Application of Olmesartan Medoxomil

Olmesartan is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Olmesartan belongs to a class of drugs called angiotensin receptor blockers (ARBs).
Olmesartan works by relaxing blood vessels so that blood can flow more easily.

 

The COA of Olmesartan Medoxomil

 

Item

Specification

Result

Appearance

White or almost white crystalline powder

white crystalline powder

Identification
IR
HPLC
UV


Must conform to reference standard
Must conform to reference standard
Must conform to reference standard


Conforms
Conforms
Conforms

Water

≤0.5%

0.18%

Residue On Ignition

≤0.1%

0.06%

Heavy Metals

≤0.001%

<0.001%

Related Compounds
Olmesartan RRT 0.2
Olmesartan medoxoil
related compound A. RRT
0.7

≤0.5%
≤0.1%

0.2%
0.14%

Assay

98.5%~101.5% on the anhydrous and solvent-free basis

99.5%

Conclusion

The results conforms with USP standards

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