Antipyretic Analgesic CAS 25122-46-7 clobetasol propionate powder

What is Clobetasol Propionate?

Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase.

Clobetasol propionate is a dermatological drug. External application is suitable for chronic eczema, neurodermatitis, psoriasis, palmoplantar pustulosis, lichen planus, discoid lupus erythematosus and other glucocorticoid topical treatment effective pruritic and non-infectious inflammatory skin diseases.
This product has a rapid effect and is one of the most potent high-efficiency topical corticosteroids currently used in clinical practice. It has a strong capillary vasoconstriction effect, and its anti-inflammatory effect is 112.5 times that of hydro'corti'sone, 2.3 times that of beta'methasone sodium phosphate, and 18.7 times that of fluocinolone. The systemic adverse reactions are 3 times that of fluocinolone, anhydrous sodium retention, and a certain promotion of sodium and potassium excretion.

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Function of Clobetasol Propionate

Clobetasol Propionate can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance

Clobetasol Propionate is Suitable for eczema, neurodermatitis, psoriasis, chronic palmoplantarPustulosis, Lichen Planus, Discoid Lupus Erythematosus effectively treatedby external use of glucocorticoids, such as itching and noninfectiousinflammatory skin diseases...

Adrenocorticotropic hormone drugs, anti-inflammatory, anti-allergic and anti-drug more effective, and promoting the removal of potassium sodium retention is very light, intramuscular or intravenous pituitary - adrenal strong inhibition:

1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.

2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins.

Application of Clobetasol Propionate

Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance

Suitable for eczema, neurodermatitis, psoriasis, chronic palmoplantarPustulosis, Lichen Planus, Discoid Lupus Erythematosus effectively treatedby external use of glucocorticoids, such as itching and noninfectiousinflammatory skin diseases