| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO9001 |
| Model Number: | Pregabalin |
| Minimum Order Quantity: | 1kg |
| Price: | 280USD/kg |
| Packaging Details: | 1.1kg/bag;25kg/drum 2. Inside: steril plastic bag+aluminum foil bag Outside: carton/drum |
| Delivery Time: | 3-7days |
| Payment Terms: | T/T, Western Union,, L/C, D/A, D/P |
| Supply Ability: | 10Metric tons per month |
| Product Name: | Pregabalin | Appearance: | White Crystalline Powder |
|---|---|---|---|
| CAS No.: | 148553-50-8 | Molecular Formula: | C8H17NO2 |
| Shelf Life: | 24months When Properly Stored | Purity: | 99%min |
| HS Code: | 2915900090 | Function: | Antiepileptic And Anticonvulsant |
| Storage Condition: | Keep Away From Heat, Open Flames And Sparks. | Whatsapp: | +86152 029 61574 |
| Email: | Gary@xahnb.com | ||
| High Light: | CAS 148553-50-8 Pregabalin Powder,Pregabalin Antipyretic Analgesic,Pregabalin Powder Antiepileptic |
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Antiepileptic pregabalin powder CAS 148553-50-8
Pregabalin, chemical name (S) -3-aminomethyl-5-methylhexanoic acid, molecular formula is C8H17NO2, is an antiepileptic drug, clinical mainly for the treatment of post-herpetic neuralgia.
Pregablin is an analogue of the neurotransmitter gamma-aminobutyric acid (GABA), marketed under the brand name Lyrica. In December 2004, the FDA approved pregablin as a treatment for diabetic neuroalgia and herpes zoster neuroalgia Pregabalin was the first drug approved in both the United States and Europe for the treatment of both types of pain. In June 2005, pregabalin was approved in the European Union for the treatment of generalized anxiety disorder (GAD) and social anxiety disorder (SAD) in March 2006. Pregabalin has a good therapeutic effect on epilepsy, various animal epilepsy model studies show that pregabalin can significantly prevent seizures, its active dose is 3-10 times lower than gabapentin. Studies have found that pregabalin can reduce the sensation of toe tip stimulation and motor spinal reflex, reduce diabetes in rats Pregabalin may have advantages when used in combination with opioids. Pregabalin may provide a new option for the clinical treatment of neuropathic pain At the same time, due to the lack of clinical experience in the application of this drug and the lack of large-scale multi-center clinical studies reported in China, it is necessary to pay close attention to the efficacy and related side effects of the use of pregabalin, and actively carry out pain reassessment and other relevant indicators of the examination, and strengthen the follow-up of patients
The affinity between pregabalin and α2-δ sites (a voltage-gated calcium channel auxiliary subunit) in central nervous system tissues is high, although the mechanism of action of pregabalin is not fully understood However, modified mouse results and studies of structurally-similar compounds such as gabapentin suggest that binding of pregabalin to α2-δ is associated with pain inhibition and antiepileptic effects in animal models Pregabalin is a structural analogue of the inhibitory neurotransmitter γ -aminobutyric acid (GABA), which is not directly related to GABAA Binding of GABAB or benzodiazepine receptor did not enhance the response of GABAA in cultured neurons and did not change the concentration of GABA in rat brain, which had a temporary effect on the reuptake and degradation of GABA Cultivation of neurons, however, long-term exposure to pregabalin, pregabalin increased the concentration of GABA transporters, and improve the transfer efficiency of GABA pregabalin won't block sodium channels, has no effect on the receptors, can not influence the activity of an enzyme called cyclooxygenase Pregabalin for serotonin and dopamine receptor inactive effect, to serotonin Dopamine and norepinephrine reuptake were not inhibited
Function:
Pregabalin is a γ -aminobutyric acid (GABA) analogue, similar in structure and action to gabapentin, with anti-epileptic, analgesic and anti-anxiety activities. The mechanism of antiepileptic action of pregabalin is still unclear. In laboratory studies, pregabalin showed anticonvulsant activity in various epileptic models; The activity profile of animal models was similar to that of gabapentin, but pregabalin was 3-10 times more active than gabapentin
Product analysis report
| CAS number | 148553-50-8 | Product Name | Pregabalin |
| Manufacture Date: | 24th Nov.,2021 | Analysis Date: | 24th Nov.,2021 |
| Batch NO.: | HNB211124-1 | Test sample: | 200gram |
| Storage: | Store in cool&dry place, in well-closed containers. | ||
| Shelf life: | 24 Months when properly stored. | ||
| ITEMS | SPECIFICATIONS | RESULT |
| Appearance | White off-white crystalline powder | Complies |
| Assay | 98.0%-102.0% | 99.2% |
| Identification |
The retention time of the major peak in the chromatogram of theAssay prepration corresponds to that in the chromatogram of the standard preparation,as obtained in the assay |
Complies |
| Specific rotation | Between -28.6°and -35.0°, measured at 20° | -32.8° |
| Water | NMT 0.5% | 0.12% |
| Residue on ignition | NMT 0.2% | 0.11% |
| Heavy metals | NMT 0.001% | Complies |
| Related compounds by hplc |
Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% |
Fructose: 0.03% Compound A: 0.04% Total impurities: 0.07% |
| Particle size | 90% less than 350 microns | Complies |
| Limit of sulfamate and sulfate |
Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10% |
Complies |
| Residual Solvent | Methylene Chloride not more than 250μg/g | Not detected |
| Acetone not mor than 2500μg/g | ||
| Isopropanol not more than 5000μg/g | ||
| Ethanenitrile not more than 400μg/g | ||
| n-hexane not more than 290μg/g | ||
| Ethyl Acetate not more than 2500μg/g | ||
| Pyridine not more than 100μg/g | ||
| Conclusion | Conform with the Standard | |
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