API Pharmaceutical Raw Material Cortisol EP / USP 99% Hydrocortisone Powder CAS 50-23-7

API Pharmaceutical Raw Material Cortisol EP/USP 99% Hydrocortisone Powder CAS 50-23-7

The Introductction of Hydrocortisone

Hydrocortisone, abbreviated as HC, also known as Cortisol, is an important adrenal glucocorticoid, whose chemical name is 11β,17α,21-trihydroxypregn-4-ene-3,20-dione, and its pharmacological action is to act on the target cells through diffusion, bind to its receptor, and form steroi*-receptor complexes.The activated steroi*-receptor complexes The activated steroi*-receptor complex acts as an activator of gene transcription and binds to specific sequential strands on DNA in the form of a dimer to regulate gene transcription, increase the production of mRNA and use it as a template to synthesize the corresponding proteins, which realize the physiological and pharmacological effects of steroi* hormones in the target cells.

Hydrocortisone is white or off-white crystalline powder, odorless, bitter taste. Degraded by light.Mp214-220°C(decomposition);Specific optical rotation[α]25D+157.5°(dioxane),+176°(chloroform),+162°-+169°(ethanol);Ethanol solution has the maximum absorption at 242nm wavelength. It is insoluble in water, insoluble in ethe*, slightly soluble in chloroform, soluble in aceton*, ethanol. It is soluble in concentrated sulfuric acid solution and shows green fluorescence.LD50 (rat, intraperitoneal) 150mg/kg.

Hydrocortisone can affect glucose metabolism, and has anti-inflammatory, anti-viral, anti-shock and anti-allergic effects.

The Application & Function of Hydrocortisone

Hydrocortisone pharmacological effects are mainly:
1. Anti-inflammatory effect: Hydrocortisone reduces and prevents the reaction of inflammation in the body by reducing the permeability of capillaries, stabilizing the activity of lysosomal membranes, and preventing the accumulation of leukocytes at the site of inflammation, so as to achieve the effect of alleviating inflammation;
(2) Immunosuppressive effect: hydrocortisone prevents or inhibits cell-mediated immune response by accelerating the apoptosis of lymphocytes in the organism and preventing the formation of mononuclear macrophages;
3. Antiviral effects: Bacterial endotoxin produced by bacteria can damage human cells, and hydrocortisone can counteract its damaging effects on the body and exert antiviral effects. The effect of hydrocortisone is similar to that of dexamethasone, but the degree of its adverse effects is milder than the latter, and it is mainly used in the treatment of adrenocortical hyperplasia, but also used in rheumatoid arthritis, antiviral, allergic diseases, and can be used in serious infections and anti-shock treatment, etc.

Applications
Hydrocortisone is mainly used in the replacement therapy of hypoadrenocorticism and the treatment of congenital adrenocortical hyperplasia, also used in rheumatoid arthritis, rheumatic fever, gout, bronchial asthma, allergic diseases, and can be used in the treatment of serious infections and antishock therapy, etc. HC is also the raw material for the preparation of several other important steroi*al drugs.

Other Name of Hydrocortisone

cortisol
Cortanal
Hydrocortisone
compoundf(kendall)
Hydrocortisone Base
HYDROCORTISONE MICRONIZED
Prednisolone EP Impurity A
21-Trihydroxypregn-4-ene-3
Hydrocortisone Acetate Impurity?A
Hydrocortisone, Chromatographic Standard
11,17,21-trihydroxypregn-4-ene-3,20-dione
11,17a,21-Trihydroxy-4-pragnene-3,20-dione
(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
11beta,17alpha,21-Trihydroxypregn-4-ene-3,20-dione
11-beta,17-alpha,21-trihydroxypregn-4-ene-3,20-dione
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The COA of Hydrocortisone