| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Dioxopromethazine Hydrochloride |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 15374-15-9 | Mf: | C17H17ClN2O2S |
|---|---|---|---|
| MW: | 348.85 | Specification: | 99% |
| EINECS: | N/A | Appearance: | White Crystalline Powder |
| Sample: | Available | Other Name: | Dioxopromethaxine HCL |
Cough Suppressant APIs USP 99% Dioxopromethazine Hydrochloride Powder CAS 15374-15-9
|
Product name |
Dioxopromethazine Hydrochloride |
|
Appearance |
White crystalline powder |
|
CAS |
15374-15-9 |
|
MF |
C17H17ClN2O2S |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introductction of Dioxopromethazine Hydrochloride
Dioxopromethazine Hydrochloride white or slightly yellow powder or crystalline powder, odorless, bitter taste. Soluble in water, slightly soluble in ethanol.
Dioxopromethazine hydrochloride is a derivative of isopromethazine, has a strong histamine H1 receptor blocking effect, can counteract the spasmodic contraction of isolated bronchial and gastrointestinal smooth muscle and bronchospasm in vivo caused by histamine, can also partially counteract the hypotension produced by intravenous injection of histamine; this product can directly inhibit the cough center, but also has a strong analgesic, expectorant effect, can inhibit guinea-pig cough due to citric acid aerosol inhalation, but also can improve the cough threshold of electric stimulation of guinea-pig vagus nerve; this product can also significantly enhance the patient's immune function, also has a certain anti-inflammatory effect, local anesthetic effect and central sedative effect. Electrical stimulation of the guinea pig vagus nerve cough threshold; the product can also significantly improve the patient's immune function, also has a certain anti-inflammatory effect, local anesthetic effect and central sedative effect.
The Application & Function of Dioxopromethazine Hydrochloride
Dioxopromethazine hydrochloride has a strong cough suppressant effect, may be on the center to play a pharmacological effect, inhibit the medulla oblongata cough center, and have antihistamine, relieve smooth muscle spasm, anti-inflammatory, local anesthesia and other effects, but also asthma, expectorant effect.
Dioxopromethazine hydrochloride is suitable for cough, allergic asthma, urticaria and pruritus, etc., which belongs to the category of anti-allergic drugs and antihistamines.
Other Name of Dioxopromethazine Hydrochloride
Prothanon;
Keke Min;
Dioxoprome;
Dioxoprothazine;
Dioxypromethazine;
ProMethazine Sulfone;
9,9-Dioxopromethazine;
DIOXOPROMETHAZINE HCL;
Dioxopromethaxine HCL;
Promethazine Impurity 5
The COA of Dioxopromethazine Hydrochloride
| ITEMS OF ANALYSIS | SPECIFICATION | RESULT |
| Appearance | White to pale yellow powder | Complies |
| Identification | IR: The IR absorption map should be consistent with that of chloroquine sulfate | Complies |
|
The reaction of Chloride |
Complies | |
| Clarify and color of solution | The solution should be clear and the color should not be darker than yellow 2 | Complies |
| Sulphate | ≤ 0.025% | 0.012% |
| pH | 4.2 - 5.1 | 4.9 |
| Related substances | Single Impurities: ≤0.5% | Complies |
| Total impurities: ≤1% | Complies | |
| Heavy Metals | ≤ 10ppm | Complies |
| Loss on drying | ≤ 0.5% | 0.35% |
| Residue on ignition | ≤ 0.1% | Complies |
| Assay(Dry based) | ≥ 99% | 99.9% |
| Conclusion | Confirm with the standard |