| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Chloroquine Diphosphate |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 50-63-5 | Mf: | C18H32ClN3O8P2 |
|---|---|---|---|
| MW: | 515.86 | Specification: | 99% |
| EINECS: | 200-055-2 | Appearance: | White Crystalline Powder |
| Sample: | Available | Other Name: | Chloroquine Phosphate |
Antivirus APIs Chloroquine Phosphate USP 99% Chloroquine Diphosphate Powder CAS 50-63-5
|
Product name |
Chloroquine Phosphate |
|
Appearance |
White crystalline powder |
|
CAS |
50-63-5 |
|
MF |
C18H32ClN3O8P2 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introductction of Chloroquine Phosphate
Chloroquine phosphate is white crystalline powder, odorless, bitter taste. Gradually change color when exposed to light; aqueous solution shows acidic reaction. It is soluble in water, almost insoluble in ethanol, trichloromethane and ethe*. Melting point is 193~196℃, decomposed at the same time when melting.
Chloroquine phosphate belongs to 4-aminoquinoline antimalarials, which can inhibit the nucleic acid synthesis of Plasmodium falciparum schizonts, interfere with the growth and reproduction of Plasmodium falciparum, and have high efficient killing effect on Plasmodium falciparum intra-erythrocytic stage schizonts.
Chloroquine phosphate has a strong binding force with nuclear proteins, and through the proximity of the negatively charged 7-chloro group on its quinoline ring to the 2-amino group on DNA guanine, chloroquine is inserted between the two strands of the double helix of DNA. It forms a complex with DNA, thus preventing DNA replication and RNA transcription. Chloroquine also inhibits phosphoric acid doping of Plasmodium DNA and RNA, interfering with Plasmodium reproduction due to reduced nucleic acid synthesis.
The Application & Function of Chloroquine Phosphate
Chloroquine phosphate is used for the treatment of chloroquine-sensitive Plasmodium falciparum, Plasmodium vivax, and Plasmodium triple day malaria.
Chloroquine phosphate is used for suppressive prophylaxis of malaria symptoms.
Chloroquine phosphate is also used in the treatment of parenteral amebiasis, connective tissue diseases, and photosensitivity diseases (e.g., sun erythema).
Other Name of Chloroquine Phosphate
Arechin
3377 RP
Avloclor
Alermine
AI3-14952
UNII-6E17K3343P
Aralen phosphate
Aralen diphosphate
chloroquin Phosphate
Chloroquine phosphate
Chlorochin diphosphate
Chloroquine diphosphate
dl-Chloroquine diphosphate
Chloroquine bis(phosphate)
7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
The COA of Chloroquine Phosphate
| ITEMS OF ANALYSIS | SPECIFICATION | RESULT |
| Appearance | White Crystalline Powder | Complies |
| Identification | IR: The IR absorption map should be consistent with that of chloroquine sulfate | Complies |
|
The reaction of phosphates should be apparent |
Complies | |
| Clarify and color of solution | The solution should be clear and the color should not be darker than BY5 | Complies |
| pH | 3.8 - 4.3 | 4.0 |
| Related substances | Other Impurities: ≤0.5% | Complies |
| 0.5%-1.0% Number of impurities: ≤1 | Complies | |
| Heavy Metals | ≤ 20ppm | Complies |
| Loss on drying | ≤ 2.0% | 1.05% |
| As | 5ppm | Complies |
| Assay(Dry based) | 98.0%~101.0% | 99.9% |
| Conclusion | Confirm with the standard |