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CAS 134678-17-4 API Pharmaceutical Antiviral Agent Lamivudine Powder Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: HNB-Lamivudine
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 134678-17-4 Mf: C8H11N3O3S
MW: 229.256 Specification: ≥98%
Appearance: White Powder Purity: 99%,99%min
Shelf Life: 2 Years Grade: Medical Grade,Phamaceutical Grade,Medicine & Tech,USP BP FCC EP
High Light:

Pharmaceutical Grade Lamivudine Powder Powder

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CAS 134678-17-4 API Pharmaceutical

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Antiviral Agent Lamivudine Powder Powder


Product Description

CAS 134678-17-4 Lamivudine powder API antiviral agent powder

 

The Introductction

 

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTIs). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and the reverse transcriptase of hepatitis B virus.

Lamivudine, an organic compound with the chemical formula C8H11N3O3S, is primarily used as an antiviral and has a competitive inhibitory effect on the synthesis and lengthening of viral DNA strands.

 

 

Product Name: Lamivudine
Synonyms:

(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

CAS: 134678-17-4
MF: C8H11N3O3S
MW: 229.256

 

CAS 134678-17-4  API Pharmaceutical Antiviral Agent Lamivudine Powder Powder 0

 

The Application & Function

 

Lamivudine use for Hepatitis B, hepatitis B virus replication of chronic hepatitis B.

 
1, suitable for treatment: chronic hepatitis B; According to the National Viral Hepatitis Prevention and Control Program, diagnosed with chronic hepatitis B, regardless of gender, age 16 years or older, and meet the following criteria.
 
(1) HBeAg positive, HBV DNA positive (HBV DNA positive refers to dot hybridization, not PCR positive, there are conditions can be quantitative determination of HBV DNA. Where there is no condition to test for HBV DNA, a positive HBeAg may prevail).
 
(2) HBeAg negative, anti-HBE positive, HBV DNA positive, considering the pre-C region variation is also suitable for treatment.
 
(3) ALT was higher than normal and bilirubin was lower than 50μmol/L (3.0mg/dL).
 
Lamivudine, as an antiviral, is used in the treatment of hepatobiliary diseases caused by hepatitis B virus infection. Randomized controlled clinical trials at home and abroad have shown that oral administration of 100 mg per day can significantly inhibit HBV DNA levels, and the serological conversion rate of HBeAg increases with the extension of treatment time. The HBeAg serum conversion rates were 22%, 29%, 40%, 47% and 50% after 1, 2, 3, 4 and 5 years of treatment, respectively. The serological conversion rate of HBeAg was also higher in patients with higher ALT level before treatment. Long-term treatment can reduce inflammation and reduce the incidence of liver fibrosis and cirrhosis. Randomized controlled clinical trials have shown that this drug can reduce the incidence of liver decompensation and HCC (hepatocellular carcinoma). It can also improve liver function and prolong survival in patients with decompensated cirrhosis. The results of foreign studies show that the efficacy of lamivudine in the treatment of chronic hepatitis B in children is similar to that in adults, and the safety is good.
 
Lamivudine was used before transplantation in patients with hepatitis B liver transplantation. After transplantation, lamivudine combined with HBIG can significantly reduce HBV reinfection after liver transplantation and reduce the dose of HBIG.

 

The COA

 

Item Specification Results
APPEARANCE WHITE CONFORMS
SOLUBILITY FREELY SOLUBLE IN CHLOROFORM;SOLUBLE IN WATER OR METHANOL; CONFORMS
PH 5.0-7.2 6.51
LOSS ON DRYING ≤4.5% 3.10%
RESIDUEON IGNITION ≤2.5% 0.281%
HEAVY METALS ≤20PPM <15PPM
TYRAMINE ≤0.35% 0.051%
RELATED COMPOSITIONS TYLOSIN A ≥80% A+B+C+D ≥95% 93% 98%
Conclusion Confirm with the standard  

 

CAS 134678-17-4  API Pharmaceutical Antiviral Agent Lamivudine Powder Powder 1CAS 134678-17-4  API Pharmaceutical Antiviral Agent Lamivudine Powder Powder 2CAS 134678-17-4  API Pharmaceutical Antiviral Agent Lamivudine Powder Powder 3CAS 134678-17-4  API Pharmaceutical Antiviral Agent Lamivudine Powder Powder 4

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