CAS 54-85-3 Isoniazid powder factory supply antibiotics API powder

Isoniazid can inhibit and kill tuberculosis bacilli, and has good biofilm penetration. Because of its good efficacy, low toxicity, low price and convenient oral administration, it is listed as the first choice anti-tuberculosis drug. The oral absorption rate of isoniazid was 90%. The serum drug concentration can reach the peak 1 ~ 2 hours after taking. Vd was 0.61±0.11L/kg, and the protein binding rate was very low. The product is metabolized in the body mainly by acetylation and partly by hydrolysis. Due to genetic differences, the population can be divided into fast acetylation and slow acetylation. Their half-lives differ significantly, with the average t1/2 for fast acetylators being 1.1 hours. For slow acetylation, it is 3 hours. It easily passes the blood-brain barrier. It is mainly used for the progressive stage of various types of tuberculosis, dissolution and spread period, absorption and improvement period, and can also be used for tuberculous meningitis and other extrapulmonary tuberculosis. It is often used in combination with other anti-TB drugs to enhance efficacy and overcome resistant bacteria. In addition to dysentery, pertussis, stes also have a certain effect.

Isoniazid is highly selective to Mycobacterium tuberculosis and has strong antibacterial effect. The concentration of 0.025 ~ 0.05mg/L in test tube can inhibit bacteria, and the concentration of 10mg/L has bactericidal effect on bacteria in breeding period. For dormant tuberculosis bacteria, increasing drug concentration or extending contact time can also have bactericidal effect. It has the same killing effect on tuberculosis bacteria both inside and outside the cell. Isoniazid alone is easy to produce drug resistance, and combined administration can delay the development of drug resistance and enhance the curative effect. There is no cross-resistance between isoniazid and other anti-TB drugs.