API Pharmaceutical colchicum autumnale extract 98% colchicina colchicine powder

API Pharmaceutical colchicum autumnale extract 98% colchicina colchicine powder

Colchicine is an ancient remedy for the treatment of articular pain. Use of Colchicum alkaloid for the treatment of acute
gout occurred as early as 1810, and reports of its medicinal value exist from the first century AD. Colchicine is the
preferred agent in the treatment of acute gouty arthritis.

Colchicine treats joint pain and swelling due to gout. Colchicine also helps to prevent gout and gouty attacks. Colchicine
relieves pain and reduces the inflammation of acute gouty arthritis. Generic colchicine tablets are available.

Colchicine, also known as colchicine, is an alkaloid extracted from the bulbs and seeds of colchicine in the liliaceae family. It is naturally found in Jialan and Lijiang Shanchi mushrooms in the biaceae family, with 0.11% and 0.1% content respectively. Light yellow acicular crystal. Slightly smelly, bitter taste. Melting point 157℃, easy to dissolve in cold water, alcohol, chloroform and formaldehyde, in hot water solubility is poor, not easy to dissolve in benzene and eth, almost insoluble in petroleum etr, 0.5% solution pH is 5.9, after ammonia hydrolysis can reduce the toxicity. Colchicine has the effect of inhibiting cell mitosis and antitumor. In 1889, Italian scholar Perniche first discovered the influence of colchicine on mitosis. He described that the middle division of the lining cells of the dog stomach was inhibited by colchicine, the spindle was destroyed, the action of chromosomes was paralyzed, and a large number of abnormal mitotic cells stayed in the middle. This abnormal division caused by colchicine is called colchicine mitosis (C-mitosis). Colchicine is one of the most widely used chemicalbooks in karyotype analysis and polyploid mutagenesis. The concentration of its aqueous solution is positively correlated with its effect. The higher the concentration, the stronger the effect. Various plants and different tissues react differently to colchicine. Generally speaking, the treatment time of young and rapidly dividing tissue (such as germinating seed germ) can be shorter, the concentration should be lower; Conversely, the processing time can be longer, and the concentration should be higher. The effective concentration of colchicine treatment is 0.01 ~ 0.4%, and about 0.2% is the most widely used. Tetraploid watermelon can be induced by dropping colchicine solution with a concentration of 0.2-0.4% on the growth point of diploid watermelon seedlings once a day for 4 consecutive days and keeping humidity in shade. For cereal crops, such as rice, healthy seedlings with more than four true leaves can be cut all the ways at the root neck, and immersed in colchicine solution of 0.025 ~ 0.05% with no cut growth point as the degree, the cut can be submerged, and tetraploid plants can be obtained after 8 ~ 14 days (20℃). Colchicine is widely used in chromosome doubling of haploid plants derived from anther (powder) and ovary culture.

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Colchicine, an antigout drug, has a good effect on acute gout, which can quickly relieve pain and prevent the onset of arthritis. Its mechanism of action is related to inhibiting leukocyte proliferation and activity and affecting lysosome release. The pharmacological action of this product is to reduce the inflammation caused by uric acid crystals by reducing the activity and phagocytosis of white blood cells in inflammatory tissues, so as to play anti-inflammatory, detumescence and analgesic effects, so it has selective anti-inflammatory effects on acute gouty arthritis. In addition, this product is also a mitotic toxin, which has a strong inhibitory effect on cell division, so that cells stop in the division period, resulting in the death of tumor cells, so it can be used in cancer treatment. After oral administration, this product is easy to absorb, 30% binds to plasma protein, the peak time of blood concentration after oral administration is 0.5 ~ 2 hours, the peak concentration of oral 2mg is about 2.2ng/ml, the effect of acute pain Chemicalbook wind 12 hours after administration, lasting 50 ~ 70 hours. The concentration of the drug in isolated neutrophils was higher than the plasma concentration and remained there for up to 10 days. Most of this product is metabolized by the liver, metabolites and protodrugs are excreted by bile, reabsorbed through the intestine, and unabsorbed ones are excreted by the intestine. About 10% ~ 20% of the rest is excreted in urine through the kidney. This product does not affect the production, dissolution and excretion of urate, so it has no effect on lowering blood uric acid. It is clinically used to treat acute attack of gouty arthritis, prevent acute attack of recurrent gouty arthritis, familial Mediterranean fever, leukemia, skin cancer, Hodgkin's disease, aplastic anemia, etc. It is also used for the cycle specific treatment of breast cancer, lung cancer, esophageal cancer, cervical cancer, nasopharyngeal cancer, Hodgkin's disease, chronic myelogenous leukemia, skin cancer and other malignant diseases at the M stage