| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Pregabalin |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 148553-50-8 | Mf: | C8H17NO2 |
|---|---|---|---|
| MW: | 159.23 | Specification: | 99% |
| EINECS No.: | 604-639-1 | Appearance: | White Crystalline Powder |
| Other Name: | Lyrica |
99% Antiepileptics Lyrica Pure Powder 99% Pregabalin CAS148553-50-8
|
Product name |
Pregabalin |
|
Appearance |
White crystalline powder |
|
CAS |
148553-50-8 |
|
MF |
C8H17NO2 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introductction of Pregabalin
Pregabalin is a gamma-aminobutyric acid (GABA) analogue with similar structure and action to gabapentin, with antiepileptic, analgesic and anxiolytic activities. The mechanism of the antiepileptic action of pregabalin is unclear. In laboratory studies, pregabalin showed anticonvulsant activity in various epilepsy models; the activity spectrum in animal models was similar to that of gabapentin, but the activity of pregabalin was 3-10 times higher than that of gabapentin
After oral administration, Pregabalin has an onset of action within 30 min and a duration of about 5 h for acute dental pain and 1 week for diabetic neuropathy. The time to peak is about 1h, and the bioavailability is 90%. It is less metabolized in the liver, 92%-99% is excreted in its original form through the kidney, and less than 0.1% of the oral dose is excreted in the feces, with a half-life of 5-6.5h.
The Application & Function of Pregabalin
Indications for pregabalin
1. Neuralgia of diabetic peripheral neuropathy and post-herpetic neuralgia
2. Adjunctive treatment of partial seizures in epilepsy
3. Also used for anxiety disorders, social phobia, arthritis
Dosage
Oral administration:
1. Adjunctive treatment of partial seizures: (1) 75mg once, twice a day or 50mg once, three times a day. Depending on individual response and tolerance, the maximum amount can be increased to 600mg a day, divided into 2-3 doses. (2) For patients with intractable epilepsy in which other antiepileptic drugs are ineffective, add 150-600 mg of pregabalin a day, divided into 2-3 doses.
2. Neuralgia in diabetic peripheral neuropathy: initial dose of 50 mg once, 3 times a day; may be increased to 100 mg once, 3 times a day within 1 week depending on efficacy and tolerability [2].
3. Post-herpetic neuralgia: initial dose of 75 mg twice a day or 50 mg three times a day; may be increased to 300 mg a day within one week depending on efficacy and tolerability. maintenance dose of 75-150 mg twice a day or 50-100 mg three times a day [3].
4. Generalized anxiety disorder: 300-600mg a day
5. Social phobia: 200mg once, 3 times a day
6. Post-operative dental pain: 300mg once and can be repeated every 6 hours according to the duration of anesthesia.
Dose on dialysis: supplemental dose should be given immediately after hemodialysis
Other Name of Pregabalin
CI 1008
CI-1008
PD 144723
Pregablin
PD-144723
pregabalin
PREGABALIN
TOS-BB-0910
(R)-Pregabalin
(S)-Pregabalin
3-isobutyl GABA
Pregabalin [USAN]
(R-)-3-isobutyl GABA
Pregabalin intermediate
PREDNISOLONESODIUMPHOSPHATE
3-(aminomethyl)-5-methyl-(S)-Lyrica
3-(aminomethyl)-5-methyl-hexanoic acid
3-(Aminomethyl)-5-methyl-hexanoic acid
3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
(3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
(3R)-3-(aminomethyl)-5-methylhexanoic acid
3-(aminomethyl)-5-methyl-(3S)-Hexanoic acid
(S)(+)-3-Aminomethyl-5-methyl-hecanoic acid
(3S)-3-(aminomethyl)-5-methyl-hexanoic acid
The COA of Pregabalin
| CAS number | 148553-50-8 | Product Name | Pregabalin |
| Manufacture Date | 24th Mar.,2023 | Analysis Date | 23th Mar.,2023 |
| Batch NO. | HNB230324-1 | Expiry Date | 22th Mar.,2025 |
| Test sample | 100gram | ||
| Storage | Store in cool&dry place, in well-closed containers. | ||
| Shelf life | 24 Months when properly stored. | ||
| TEST ITEMS | SPECIFICATIONS | RESULT |
| Appearance | White crystalline powder | Complies |
| Assay | 98.0%-102.0% | 99.2% |
| Identification | The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation,as obtained in the assay | Complies |
| Specific rotation | Between -28.6°and -35.0°, measured at 20° | -32.8° |
| Water | ≤ 0.5% | 0.12% |
| Residue on ignition | ≤ 0.2% | 0.11% |
| Heavy metals | ≤ 0.001% | Complies |
| Related compounds by hplc | Fructose ≤ 0.3% | 0.03% |
| Compound A ≤ 0.3% | 0.04% | |
| Other individual impurity ≤ 0.1% | 0.01% | |
| Total impurities not more than 0.5% | 0.08 | |
| Particle size | 90% less than 350 microns | Complies |
| Limit of sulfamate and sulfate |
Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10% |
Complies |
| Residual Solvent | Methylene Chloride not more than 250μg/g | Not detected |
| Aceton* not mor than 2500μg/g | ||
| Isopropanol not more than 5000μg/g | ||
| Ethanenitrile not more than 400μg/g | ||
| n-hexane not more than 290μg/g | ||
| Ethyl Acetate not more than 2500μg/g | ||
| Pyridine not more than 100μg/g | ||
| Conclusion | Conform with the USP Standard | |