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API Pharmaceutical 98% Rapamycin Powder Anti-rejection CAS 53123-88-9

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Rapamycin
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 53123-88-9 Mf: C51H79NO13
MW: 914.17 Specification: 99%
EINECS No.: 262-640-9 Appearance: White Crystalline Powder
Sample: Available

Product Description

API Pharmaceutical 98% Rapamycin Powder Anti-rejection CAS 53123-88-9

API Pharmaceutical 98% Rapamycin Powder Anti-rejection CAS 53123-88-9 0

Product name



White crystalline powder








Keep in cool dry place.

API Pharmaceutical 98% Rapamycin Powder Anti-rejection CAS 53123-88-9 1


The Introductction of Rapamycin


Rapamycin (RAPA) is a new type of macrolide immunosuppressant, a white solid crystal, melting point 183-185℃, lipophilic, soluble in methanol, ethanol, chloroform and other organic solvents, very slightly soluble in water, 

Rapamycin (also known as "sirolimus") is a secondary metabolite secreted by Streptomyces soil from the soil of Easter Island, Chile for the first time in 1975, and its chemical structure belongs to the "triene macrolide" compounds.

Rapamycin is a macrolide antibiotic, similar in structure to plucofosfamide (FK506), but with very different immunosuppressive mechanisms. fK506 inhibits the proliferation of T lymphocytes from G0 to G1 phase, while RAPA blocks the progression of T lymphocytes and other cells from G1 to S phase by blocking signaling through different cytokine receptors, compared to FK506. RAPA blocks calcium-dependent and non-calcium-dependent signaling pathways in T lymphocytes and B lymphocytes.


The Application & Function of Rapamycin


Rapamycin, a targeted inhibitor of mTOR, is able to treat tumors closely related to this pathway including kidney, lymphoma, lung, liver, breast, neuroendocrine and gastric cancers. It is particularly effective in the treatment of LAM (lymphangioleiomyomatosis) and TSC (tuberous sclerosis), two rare diseases.

Rapamycin is a new immunosuppressive agent with good efficacy, low toxicity and no nephrotoxicity.

Rapamycin is now often used as a drug to maintain immunity in transplanted organs (especially kidney transplants) to slow down immune rejection after transplantation, however, scientists have recently discovered that it has.

Another use for rapamycin: it can be used to treat Alzheimer's disease (senile dementia).


Other Name of Rapamycin:


RPM;RAPA;sirolimus(Sirolimus);RAPAMUNE;Rapamycin/Sirolimus;Rapamycin(Sirolimus);Rapamycin;RAPAMYCIN 1GM;SIROLIMUS;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,AY 22989,Sirolimus;sila9268a;Rapamycin from Streptomyces hygroscopicus;RAPAMYCIN;


The COA of Rapamycin


Product Name Rapamycin
Other Name: Sirolimus Manufacture Date: Aug-08-2022
Batch No.: HNB20220808 Analysis Date: Aug-09-2022
Batch Size: 3.9kg Expiry Date: Aug-08-2025
Grade: Medicine grade
Storage: Store in cool & dry place, in well-closed containers.
Shelf life: 36 Months when properly stored.
Appearance White or off-white powder Off-white powder
Purity(include Cis-stereoisomer) ≥98.0% 98.5%
Identification IR: Sample spectrum corresponds to that of standard spectrum Complies
Water ≤ 0.5% 0.3%
Heavy metals ≤20mg/kg Complies
Residue on ignition ≤0.2% 0.1%
Related substances Cis-Stereoisomer of Rapamycin ≤5.0% 1.6%
Single Max. Unknown imputity ≤1.0% 0.34%
Any other total impurity ≤2.0% 1.54%
Conclusion: Complies with the standard


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