Pharmaceutical API Antibacterial Streptomycin Sulfate Powder CAS 3810-74-0

Streptomycin sulfate has antibacterial effect on most gram-positive and negative bacteria, especially on a variety of gram-negative bacteria such as Escherichia coli, salmonella, Pasteurella, brucella, pneumobacter, dysentery bacillus, aerobacter, Bacillus meliosum, etc. This product is the first choice of anti-tuberculosis bacilli, the action of tuberculosis bacilli is strong, at low concentration has a strong antibacterial effect, high concentration has a bactericidal effect. Because only 10% can penetrate into the somatic cells, it is ineffective to the cell of the tuberculosis bacteria, can only kill the tuberculosis bacteria outside the cell. It has stronger bactericidal effect on breeding bacteria than resting bacteria. Unlike penicillin, its bactericidal rate is proportional to the concentration of the drug, and its antibacterial effect is strongest at pH 7.8 and greatly diminished below pH 6.

Agricultural streptomycin sulfate is an antibiotic fungicide, which can prevent and control bacterial diseases of many crops and some fungal diseases. According to the toxicity classification standard of pesticide, streptomycin belongs to low toxicity fungicide. Active agent rat acute transoral LD50>9 000mg/kg body weight. Can cause skin allergic reaction.

Streptomycin sulfate is an aminoglycoside antibiotic. Streptomycin mainly binds to the 30S subunit of bacterial ribosomes and inhibits the synthesis of bacterial proteins. Bacteria can easily develop resistance to streptomycin when exposed to it. The use of streptomycin in combination with other antibacterial or anti-tuberculosis drugs can reduce or delay the development of resistance. For the treatment of rabbit fever, plague, severe brucellosis, and gangrene (often combined with tetracycline). It is also used in the second-line treatment of tuberculosis, mostly in combination with other anti-tuberculosis drugs.