| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Trimethoprim |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, Western Union, MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 738-70-5 | Mf: | C14H18N4O3 |
|---|---|---|---|
| MW: | 290.32 | Specification: | 99% |
| Other Name: | TMP | Appearance: | Off-white Powder |
| Sample: | Available |
CAS 738-70-5 Pharmaceutical TMP Raw Material 99% Trimethoprim Powder
|
Product name |
Trimethoprim |
|
Appearance |
Off-white powder |
|
CAS |
738-70-5 |
|
MF |
C14H18N4O3 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introduction of Trimethoprim
Trimethoprim is an organic compound with the chemical formula C14H18N4O3, a white or light yellow crystalline powder, odorless, bitter in taste, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, and soluble in glacial acetic acid.
Methicillin is a synthetic broad-spectrum antibacterial agent, used alone for respiratory tract infections, urinary tract infections, intestinal infections, etc. It can be used to treat septicemia, meningitis, otitis media, typhoid fever, shigellosis (bacillary dysentery) caused by sensitive bacteria.
Methotrexate is an inhibitor of bacterial dihydrofolate reductase and is a sulfonamide synergist. Its antibacterial action principle is to interfere with bacterial folic acid metabolism. Mainly for selective inhibition of bacterial dihydrofolate reductase activity, so that dihydrofolate can not be reduced to tetrahydrofolate, thereby inhibiting the growth and reproduction of bacteria. Methotrexate has antibacterial activity against most gram-positive and gram-negative bacteria; in addition, methotrexate has certain effects on Plasmodium and certain fungi, such as Nucleus, Histoplasma, and yeast. Among the gram-positive bacteria, Streptococcus spp. containing Streptococcus pneumoniae are sensitive to meperidine. In the gram-negative bacteria, Escherichia coli, Salmonella spp., Aspergillus chimaera, S. pneumoniae, S. dysenteriae, S. typhi, S. pertussis, etc. are sensitive to meperidine. Methicillin has no antibacterial effect on Pseudomonas aeruginosa, meningococcus and alkali-producing bacilli.
The Application & function of Trimethoprim
1. Methotrexate can be used alone for the treatment of acute simple urinary tract infections and bacterial prostatitis caused by sensitive bacteria.
2,Methomyl is used in combination with sulfamethoxazole or sulfadiazine to treat sepsis, meningitis, otitis media, typhoid fever, shigellosis (bacillary dysentery), etc. caused by sensitive bacteria.
3. Meperidine in combination with sulfamethoxazole-2,6-dimethoxypyrimethamine can also be used for the treatment of chloroquine-resistant malaria.
Other Name of Trimethoprim
trimethoprim
TRIMETHOPRIM BP
Trimethopim(TMP)
Antibiotic synergist
trimethoprim crystalline
TRIMETHOPRIM, CRYSTALLIZED
methoxybenzyl aminopyrimidine
TRIMETHOPRIM VETRANAL, 250 MG
5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine
5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine
The COA of Trimethoprim
| Product Name | Trimethoprim | ||
| CAS No. | 738-70-5 | ||
| Batch No. | HNB20210122 | Manufacture Date | Jan.-22-2021 |
| Batch Size | 25kg/drum | Analysis Date | Jan.-23-2021 |
| Quantity | 2000kg | Expiry Date | Jan.-21-2023 |
| Storage | Store in cool & dry place, in well-closed containers. | ||
| Shelf Life | 24 Months when properly stored. | ||
| Reference | USP42 | ||
| ITEMS OF ANALYSIS | SPECIFICATIONS | RESULT |
| Appearance | White or yellowish-white powder | Complies |
| Identification | ||
|
A: Infrared Absorption B: Ultraviolet Absorption |
IR Conforms to standard <USP Monograph 197K> absorptivities, calculated on the dried basis, differ by NMT 3.0%<USP Monograph 197U> | Complies |
| Test | ||
| Appearance of solution | Not more intensely coloured than reference solution BY7(EP Monograph 2.2.2,MethodⅡ) | Complies |
| Melting range | 199-203°C<USP Monograph 741> | 199.6-201.2°C |
| Loss on drying | ≤0.5%<USP Monograph 731> | 0.1% |
| Residue on ignition | ≤0.1%<USP Monograph 281> | 0.02% |
| Related substances(HPLC) | ||
| A: | USP Monograph 621 | |
| Impurity E(USP related Compound A) | ≤0.1% | Not detected |
| Impurity B(USP related Compound B) | ≤0.1% | Not detected |
| Impurity F | ≤0.1% | 0.03% |
| Any other impurity | ≤0.10% | 0.04% |
| Total impurities | ≤0.2% | 0.09% |
| B: | <EP Monograph 2.2.29> | |
| Impurity F | ≤0.1% | Not detected |
| Impurity I | ≤0.1% | Not detected |
| Any other impurity | ≤0.10% | 0.02% |
| Total impurity | ≤0.2% | 0.02% |
| Impurity K.(GC) | ≤4.7ppm<EP Monograph 2.2.28> | 1.6ppm |
| Assay(% on dry basis) | 98.5%-101.0%< USP Monograph 541> | 100.2% |
| Conclusion: Complies with the USP 42 standard | ||