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CAS 738-70-5 Pharmaceutical TMP Raw Material 99% Trimethoprim Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Trimethoprim
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 738-70-5 Mf: C14H18N4O3
MW: 290.32 Specification: 99%
Other Name: TMP Appearance: Off-white Powder
Sample: Available
High Light:

99% Purity Trimethoprim Powder


Pharmaceutical TMP Raw Material


API Pharmaceutical 738-70-5

Product Description

CAS 738-70-5 Pharmaceutical TMP Raw Material 99% Trimethoprim Powder

CAS 738-70-5 Pharmaceutical TMP Raw Material 99% Trimethoprim Powder 0

Product name



Off-white powder








Keep in cool dry place.

CAS 738-70-5 Pharmaceutical TMP Raw Material 99% Trimethoprim Powder 1


The Introduction of Trimethoprim

Trimethoprim is an organic compound with the chemical formula C14H18N4O3, a white or light yellow crystalline powder, odorless, bitter in taste, slightly soluble in chloroform, slightly soluble in ethanol or aceton*, almost insoluble in water, and soluble in glacial acetic acid.

Methicillin is a synthetic broad-spectrum antibacterial agent, used alone for respiratory tract infections, urinary tract infections, intestinal infections, etc. It can be used to treat septicemia, meningitis, otitis media, typhoid fever, shigellosis (bacillary dysentery) caused by sensitive bacteria.

Methotrexate is an inhibitor of bacterial dihydrofolate reductase and is a sulfonamide synergist. Its antibacterial action principle is to interfere with bacterial folic acid metabolism. Mainly for selective inhibition of bacterial dihydrofolate reductase activity, so that dihydrofolate can not be reduced to tetrahydrofolate, thereby inhibiting the growth and reproduction of bacteria. Methotrexate has antibacterial activity against most gram-positive and gram-negative bacteria; in addition, methotrexate has certain effects on Plasmodium and certain fungi, such as Nucleus, Histoplasma, and yeast. Among the gram-positive bacteria, Streptococcus spp. containing Streptococcus pneumoniae are sensitive to meperidine. In the gram-negative bacteria, Escherichia coli, Salmonella spp., Aspergillus chimaera, S. pneumoniae, S. dysenteriae, S. typhi, S. pertussis, etc. are sensitive to meperidine. Methicillin has no antibacterial effect on Pseudomonas aeruginosa, meningococcus and alkali-producing bacilli.


The Application & function of Trimethoprim

1. Methotrexate can be used alone for the treatment of acute simple urinary tract infections and bacterial prostatitis caused by sensitive bacteria.
2,Methomyl is used in combination with sulfamethoxazole or sulfadiazine to treat sepsis, meningitis, otitis media, typhoid fever, shigellosis (bacillary dysentery), etc. caused by sensitive bacteria.
3. Meperidine in combination with sulfamethoxazole-2,6-dimethoxypyrimethamine can also be used for the treatment of chloroquine-resistant malaria.



Other Name of Trimethoprim

Antibiotic synergist
trimethoprim crystalline
methoxybenzyl aminopyrimidine


The COA of Trimethoprim


Product Name Trimethoprim
CAS No. 738-70-5
Batch No. HNB20210122 Manufacture Date Jan.-22-2021
Batch Size 25kg/drum Analysis Date Jan.-23-2021
Quantity 2000kg Expiry Date Jan.-21-2023
Storage Store in cool & dry place, in well-closed containers.
Shelf Life 24 Months when properly stored.
Reference USP42
Appearance White or yellowish-white powder Complies

A: Infrared Absorption

B: Ultraviolet Absorption

IR Conforms to standard <USP Monograph 197K> absorptivities, calculated on the dried basis, differ by NMT 3.0%<USP Monograph 197U> Complies
Appearance of solution Not more intensely coloured than reference solution BY7(EP Monograph 2.2.2,MethodⅡ) Complies
Melting range 199-203°C<USP Monograph 741> 199.6-201.2°C
Loss on drying ≤0.5%<USP Monograph 731> 0.1%
Residue on ignition ≤0.1%<USP Monograph 281> 0.02%
Related substances(HPLC)
A: USP Monograph 621
Impurity E(USP related Compound A) ≤0.1% Not detected
Impurity B(USP related Compound B) ≤0.1% Not detected
Impurity F ≤0.1% 0.03%
Any other impurity ≤0.10% 0.04%
Total impurities ≤0.2% 0.09%
B: <EP Monograph 2.2.29>
Impurity F ≤0.1% Not detected
Impurity I ≤0.1% Not detected
Any other impurity ≤0.10% 0.02%
Total impurity ≤0.2% 0.02%
Impurity K.(GC) ≤4.7ppm<EP Monograph 2.2.28> 1.6ppm
Assay(% on dry basis) 98.5%-101.0%< USP Monograph 541> 100.2%
Conclusion: Complies with the USP 42 standard

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