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Antifungal Agent Ketoconazole Powder CAS 65277-42-1 99%

Basic Information
Place of Origin: China
Brand Name: BCB
Certification: ISO
Model Number: Ciprofloxacin HCl
Minimum Order Quantity: 1
Price: 100
Packaging Details: 1kg/bag, 25kg/drum
Delivery Time: 7 working days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram
Supply Ability: 10000kg/month
Detail Information
Purity: 99% Mf: C26H28Cl2N4O4
Cas No.: 65277-42-1 Appearance: White Powder
Usage: Pharmaceutical Intermediates Shelf Life: 24 Month
Molecular Weight: 531.431 Test Method: HPLC
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Product Description

Antifungal Agent Ketoconazole Powder CAS 65277-42-1 99% Ketoconazole

 

Prodcut name Ketoconazole
MOQ 1kg
CAS No.

65277-42-1

Appearance White powder
Molecular Formula C26H28Cl2N4O4
Molecular Weight 531.431
Assay 99%
Application Pharma grade

 

Antifungal Agent Ketoconazole Powder CAS 65277-42-1 99% 0

 

The Introductction of Ketoconazole:

 

Ketoconazole is a synthetic imidaz antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff-seborrhoeic dermatitis of the scalp).


Ketoconazole is used to treat certain serious fungal infections in the body. Ketoconazole belongs to the class of drugs called azol antifungals. It works by stopping the growth of the fungus.

 

The Application & Function of Ketoconazole:

 

Pharmacology: ketoconazole belongs to azol-class antifungal drugs and has antifungal activity against various kinds of genus of deep fungal infections such as Candida, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp as well as Trichophyton. However, this product has a relative weak activity against Aspergillus, Sporothrix schenckii as well as some species of Dermateaceae and Mucor. This product, through actively interfering with the activity of cytochrome P-450, is capable of inhibiting the biosynthesis of the major steroids - ergosterol of the fungal cell membrane. Therefore, it destroys the fungal cell membrane and changes its permeability, resulting in the leakage of important intracellular material. Ketoconazole can also inhibit the biosynthesis of fungal triglyceride and phospholipid biosynthesis, inhibit the activity of oxidase and peroxidase, causing accumulation of intracellular hydrog peroxid which further leads to cell submicroscopic structural degeneration and necrosis. For candida albicans, it can also suppress the transition process from spores to aggressive mycelium.

 

Toxicology: Long-term animal toxicity experiments have showed that ketoconazole can significantly increase the level of alkaline phosphatase and cause liver cell degeneration.

 

The COA of Ciprofloxacin HCl:

 

Item Specifications
Appearance White or almost white crystal powder
Identification Conforms
Specific rotatory power -1~+10
Solubility Solution water 1:10
Clarity of solution Should be clartiy
Colour of solution ≤No.5 orange-yellow
Relation substance ≤1.5%
Loss on drying ≤0.5%
Burn Residue ≤0.1%
Heavy metals ≤0.002%
Loss on drying 0.50%
Content ≥98.5%
Microbiological Test

Bacteria :≤300cpu

Fungi: ≤100cpu

Reference addition 0.5 ~ 2.0% It can dissolve in propylene glycol at first
Conclusion The results conforms with Enterprise standards

 

 

Contact Details
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