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CAS 287714-41-4 Circulatory system medication for Anti-atherosclerosis Rosuvastatin Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Rosuvastatin
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 287714-41-4 Mf: C22H28FN3O6S
MW: 481.54 Specification: ≥98%
Einecs No.: N/A Appearance: White Powder

Product Description

CAS 287714-41-4 Circulatory system medication for Anti-atherosclerosis Rosuvastatin Powder

CAS 287714-41-4 Circulatory system medication for Anti-atherosclerosis Rosuvastatin Powder 0

Product Name






Chemical Name

1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)



Empirical Formula



1. Patients allergic to this product are not allowed. 2. Contraindicated in patients with active liver disease. 3. It is forbidden for patients with myopathy. 4. Pregnancy toxicity grade is X, pregnant women contraindicated.


For the treatment of primary hypercholesterolemia and mixed lipid disorders.




The Introductction of Rosuvastatin:


Rosuvastatin, sold under the trade name Crestor, is astatin that is used in combination with exercise, diet control and weight loss to treat hypercholesterolemia and other related conditions, as well as to prevent cardiovascular disease.


The Application & Function of Rosuvastatin:


1. Hypolipidemic effect
Rovastatin has an obvious effect on lowering blood lipids. Generally, statins can reduce the level of low density lipoprotein cholesterol (LDL-C) by 17% to 54%. The phase ii clinical trial results of rovastatin showed that when the dose was 80 mg, rovastatin reduced LDL-C by 65%, which is the best effect among statins. Rovastatin increases the number of LDL receptors. In human hepatocellular tumor, rovastatin raised the mRNA volume of LDL receptor about 10 times more than pravastatin.
2. Selective effect on hepatocytes
Cholesterol from hepatocytes is the main cause of blood cholesterol formation, while cholesterol from non-hepatocytes is necessary for normal cells. The main site of action of rovastatin is the liver. From the perspective of inhibiting sterol synthesis, the selectivity of rovastatin to rat liver was higher than that to peripheral tissues, and higher than pravastatin or simvastatin to liver tissues. Rovastatin is absorbed into liver cells through an active absorption process and is 1000 times more potent in inhibiting cholesterol in rat liver cells than in fibroblasts.
3. Anti-atherosclerosis effect
Rovastatin can reduce blood lipid, lipid infiltration and foam cell formation, which is beneficial to delay atherosclerosis. The drug can also inhibit smooth muscle cell proliferation and promote cell apoptosis by blocking the hydroxymethylglutaric acid pathway, especially the formation of isoprenoid metabolites, thus stabilizing atherosclerosis plaque and delaying the occurrence and development of atherosclerosis.




Although rovastatin has the common pharmacophore dihydroxyheptanoic acid part of statins, the rest of its molecular structure is different from other similar drugs, among which the presence of polar methylsulfonyl amino makes it present a low lipophilic. This means that its passive diffusion ability is low and it is difficult to enter non-hepatocytes. However, it can be absorbed by liver cells in large quantities through selective organic anion transport process, and has the characteristics of selective distribution and use for HMG-COA reductase in liver. At the same time, the relatively water-soluble nature of its structure enables it to avoid the defect that requires extensive metabolism of cytochrome P450 before elimination, and greatly reduces the chance of interaction with other drugs.



The COA of Rosuvastatin


Product Name Rosuvastatin Quantity 37kgs
Manufacture Date Dec, 02th, 2021 Expire Date Dec, 02th, 2023
Batch Number HNB20211202 Report Date Dec,7th, 2021
Item Specification Testing result
Appearance White or almost white powder White powder
CAS# 287714-41-4 Conforms
Identify Infrared absorption spectrum should be consistent with the standard spectrum Associated with the standard spectrum
Water NMT 3.0% 2.0%
Specific rotation: +16 - +20° +18.5°
Heavy metal ≤20ppm Conforms
Single impurity NMT 0.5% 0.4%
Total impurities NMT 1.0% 0.8%
Purity ≥99.0% 99.2%
Conclusion Conformed with EP standard


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