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99% AD Medicine Grade DMMPA Raw Material 99% Nefiracetam Powder CAS 77191-36-7

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Nefiracetam
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 77191-36-7 Mf: C14H18N2O2
MW: 246.31 Specification: 99%
Other Name: DMMPA Appearance: White Crystalline Powder
Melting Point: 151-155°C

Product Description

99% AD Medicine Grade DMMPA Raw Material 99% Nefiracetam Powder CAS 77191-36-7

99% AD Medicine Grade DMMPA Raw Material 99% Nefiracetam Powder CAS 77191-36-7 0

Product name

Nefiracetam

Appearance

White crystalline powder

CAS

77191-36-7

MF

C14H18N2O2

Purity

99%

Storage

Keep in cool dry place.

99% AD Medicine Grade DMMPA Raw Material 99% Nefiracetam Powder CAS 77191-36-7 1

 

The Introductction of Nefiracetam

 

Nefiracetam is a hydrophobic derivative of piracetam and is synthesized synthetically from all the Racetam compounds piracetam. Nefecitant is mainly produced by DaiichiSankyo (Japanese pharmaceutical company) for the treatment of Alzheimer's disease. In addition to all the mechanisms attributed to Nefiracetam, it is usually considered a substance that is found in calcium channels in vivo, as well as stimulating the indirect transfer of signaling substances as a partial agonist of the glycine binding site of the NDMA receptor.


Nefiracetam is a cognitive enhancer of the Racetam family, originally derived from the parent molecule piracetam, but most similar in structure to aniracetam. This is because nefecitam and aniracetam are lipid-soluble drugs. They are used in the treatment of memory improvement and cognitive impairment.


There are two mechanisms of action of Nefiracetam:
The first way is to prolong the opening of calcium channels (which bind to PKA and Gi/o proteins) that enhance the receptor response, regardless of the synapse .
The second way is a second pathway associated with PKC and CAMKII, whose response is completed due to cholinergic receptors (and then the most excitatory neurotransmitters released at the presynaptic level, as in the case of nicotine).
The previous pathway (calcium channels) is important in the long term, while the latter pathway (PKC/CAMKII) has an impact on the enhancement of neural signals and their transmission. Some other minor modalities can be partial agonists of NDMA receptors bound to glycine (which can enhance the interaction of certain levels of glycine, thus weakening the interaction), as well as increasing its communication with the ligand acetylcholine muscarinic acetylcholine receptor.

 

The Application & Function of Nefiracetam

 

Nefiracetam is used for the treatment of cerebrovascular diseases. It can enhance cognition and prevent impairment of learning and memory by acting on the cerebral cortex. It does not have the properties of muscarinic receptor agonist and antagonist, nor does it inhibit acetylcholinesterase activity, so its antiamnesic and memory-enhancing effects occur by increasing the release of acetylcholine from the cerebral cortex.

 

Other Name of Nefiracetam

 

DMMPA
dmppa
dm9384
NEFIRACETAM
Nefiracetam
DM-9384 DMMPA DZL-221
[(2,6-dimethylphenyl)aminocarbonylmethyl]chloride
n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid
2-oxo-1-pyrrolidinylaceticacid,2,6-dimethylanilide
n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
DM-9384, (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)

 

The COA of Nefiracetam

 

Product Name: Nefiracetam

Batch Number: HNB 20230428

Batch Quantity: 50kg

Manufacture Date: Apr.,28th,2023      Analysis Date: Apr.,29th,2023    Expiry Date: Apr.27th,2025

Storage: Store in well-closed containers, cool and dry place.

Shelf life: 2 years when properly stored.

 

ITEMS OF ANALYSIS SPECIFICATION RESULT
Appearance White crystalline powder Conforms
Assay(Dry based)
98.0%~102.0%
99.6%
Identification HPLC Conforms
Melting Point 151-155°C 153.5°C
Loss on drying ≤1.0% 0.30%
Residue on Ignition ≤0.1% 0.08%
Conclusion Conform with the standard

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