| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Nystatin |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually7-10days |
| Payment Terms: | L/C, D/A, D/P, T/T, Western Union, MoneyGram |
| Supply Ability: | 5000kg/Month |
| CAS: | 1400-61-9 | MF: | C47H75NO17 |
|---|---|---|---|
| MW: | 276.414 | Appearance: | Yellow Powder |
| Shelf Life: | 24 Months | Specification: | 99% |
Best Price Antifungal Antibiotic Raw Powder CAS 1400-61-9 Nystatin
| Prodcut name | Nystatin |
| MOQ | 1KG |
| CAS No. | 1400-61-9 |
| Appearance | Yellow powder |
| Molecular Formula | C47H75NO17 |
| Molecular Weight | 276.414 |
| Assay | 99% |
The Introductction of Nystatin :
Nystatin is a polyene antifungal drug to which many molds and yeast infections are sensitive, including Candida.Cutaneous, vaginal, mucosal and esophageal Candida infections usually respond well to treatment with nystatin.Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage and death of the fungus.
The Application & Function of Nystatin :
1. Nystatin is often used as prophylaxis in patients who are at risk for fungal infections, such as AIDS patients with a low CD4+ count and patients receiving chemotherapy.
2. It is prescribed in units, with doses varying from 100,000 (for oral infections) to 1 million (for intestinal ones). As it is not absorbed from the gut, it is safe for oral use and does not have problems of drug interactions.
3. It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 µg/mL.
4. In certain cases, nystatin has been used to prevent the spread of mold on objects such as works of art. For example, it was applied to wood panel paintings damaged as a result of the Arno River Flood of 1966 in Florence, Italy.
The COA of Nystatin :
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Test items
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Standard
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Result
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|
|
Description
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Light yellow powder
|
Conforms
|
|
|
Identification |
IR
|
IR spectrum of sample is the same as working standard
|
Conforms
|
|
HPLC
|
HPLC RT of the sample is the same as the working standard
|
Conforms
|
|
|
Melting point
|
165.0°C~169.0°C
|
Conforms
|
|
|
Optical rotation
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-23°~-29°
|
-27.4°
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|
|
Loss on drying
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NMT 1.0 %
|
0.17%
|
|
|
Residue on ignition
|
NMT 0.1 %
|
0.03%
|
|
|
Heavy metals
|
NMT 20ppm
|
Conforms
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|
|
Related substances
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|||
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Impurity A
|
NMT 0.1 %
|
Not detected
|
|
|
Impurity B
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NMT 0.1 %
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Not detected
|
|
|
Impurity C
|
NMT 0.1 %
|
0.02%
|
|
|
Single impurity
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NMT 0.2 %
|
0.17%
|
|
|
Total impurity
|
NMT 1.0 %
|
0.60%
|
|
|
Assay
|
NLT 99.0%
|
99.0%
|
|
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