| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Tacrolimus |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually7-10days |
| Payment Terms: | L/C, D/A, D/P, T/T, Western Union, MoneyGram |
| Supply Ability: | 5000kg/Month |
| MF: | C44H71NO13 | MW: | 822.033 |
|---|---|---|---|
| Appearance: | White To Light Yellow Crystalline Powder | CAS: | 104987-11-3 |
| Assay: | 99% | Melting Point: | 127-129° |
API Pharmaceutical 98% Tacrolimus powder Immunosuppressive CAS 104987-11-3
| Production name | Tacrolimus |
| MOQ | 1KG |
| CAS No. | 109581-93-3 |
| Appearance | White crystalline powder |
| Molecular Formula | C44H71NO13 |
| Molecular Weight | 822.033 |
| Assay | 99% |
The Introduction of Tacrolimus:
Tacrolimus, isolated from the microorganism Streptomyces tsukubaensis, is a macrolide immunosuppressant developed by Fujisawa for organ transplantation. It displays similar but more potent immunosuppressive activity than cyclosporin. It inhibits both cell mediated and humoral immune responses.
In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic, renal, cardiac, small intestine, pancreatic and skin allografts and to reverse cardiac and renal allograft rejection. It has been used effectively in humans as rescue or primary immunosuppressant therapy in liver or kidney transplantation.
The Application & Function of Tacrolimus :
FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
The COA of Tacrolimus :
| Items | Specifications | Result |
| Appearance | White or almost white crystalline powder | Conform |
| Identification | IR HPLC |
Conform Conform |
| Water | 1.6% to 3.0% Max | 2.2% |
| Residue on Ignition | 0.2% Max | 0.02% |
| Heavy Metals | 20 PPM Max | Conform |
| Ascomucin | 0.8% Max | 0.68% |
| Related Substances | Dihydrotacrolimus 0.6% Max Total Impurities 1.5% Max |
0.46% 0.17% |
| Residual Solvents | Aceton 2000PPM Max Ethanol 2000PPM Max |
Not Detected Not Detected |
| Assay (dried basis) | 98% to 102% | 99.1% |
| Conclusion | Conform with the Standards | |