Cas 28829-38-1 Cosmetic High Moisturizer Sodium Polyglutamate PGA-Na Powder

Cas 28829-38-1 Cosmetic High Moisturizer Sodium Polyglutamate PGA-Na Powder

The Introductction of Sodium Polyglutamate

Sodium polyglutamate, a product formed when the carboxyl group of the side chain of the glutamate unit of polyglutamic acid ionizes to form an anionic carboxylate (COO-) and then combines with sodium ions. Polyglutamic acid itself is insoluble in water and must be ionized to be soluble with water. Sodium polyglutamate has excellent water solubility, is a natural moisturizing ingredient, and is now widely used as a moisturizing ingredient in cosmetics.

Preparation method of Sodium polyglutamate: microbial fermentation to produce polyglutamic acid fermentation broth, pH adjusted to 3 with hydrochloric acid, after centrifugation to remove the bacterium, precipitation with 4 times volume of 95% ethanol, precipitate dissolved with distilled water, then precipitated again with 95% ethanol, collect the precipitate, i.e. H-type polyγ-glutamic acid (PGA-H, pH about 3), dissolve the PGA-H, neutralize with NaOH After dissolving PGA-H and neutralizing it with NaOH (pH=7), poly(γ-glutamic acid) sodium (PGA-Na) was obtained.

The Application & Function of Sodium Polyglutamate

1. Cosmetics:

Sodium polyglutamate has the effect of increasing hair toughness and reducing hair damage during hair coloring. Polyglutamic acid also has whitening effect, which can significantly inhibit tyrosinase activity and thus inhibit skin melanin production; its hydrocolloid is colorless, odorless, transparent and soft gel; it has a unique three-dimensional space structure and thus has superb water absorption and moisturizing ability. In addition, monosodium polyglutamate has the ability to inhibit hyaluronidase activity, which can alleviate the degradation of hyaluronic acid in skin connective tissue caused by the activation of hyaluronidase, thus preventing the loss of skin elasticity and wrinkles caused by the loosening of skin connective tissue.

Sodium polyglutamate may have a triple effect of whitening, moisturizing and anti-wrinkle at the same time, and its application in efficacious cosmetics will have a broad market prospect.

It is important to note that ingredients present in cosmetics containing Sodium polyglutamate include glutamic acid, monosodium glutamate, and ammonium chloride. All three components can cause a decrease in the viscosity of carbomer 941 and destroy its thickening effect, mainly by sodium ions, chloride ions, and glutamate ions. And the greater the ion concentration, the more severe the decrease in the viscosity of carbomer, but the presence of ions has little effect on the pH of the system.

2. Food
The addition of 1000 kDa to 1200 kDa PGA-Na dough has better powdering effect; the addition of 300 kDa to 400 kDa PGA-Na dough has better pulling effect and anti-freezing property .

3. Biomedical
Sodium polyglutamate is water-soluble and has the properties of water absorption, moisture retention, non-toxicity, safety, biodegradability, etc. It can increase the strength of matrix tension, promote cell proliferation and migration, and can be made into artificial skin, trauma dressings, hemostatic agents, drug release carriers, biological adhesives, and surgical sutures .

Other Name of Sodium Polyglutamate: 

28829-38-1;

SODIUM POLYGLUTAMATE;

SODIUM POLYGLUTAMATE(γ-poly-glutamic acid (γ-PGA));

Sodium Polyglutamate (sodium γ-poly-glutamic acid,

γ-PGA

PGA-NA

The COA of Sodium Polyglutamate

Product Name: Sodium Polyglutamate

Batch No.: HNB20230208

Manufacture Date: Feb., 08^th, 2023    Analysis Date: Feb., 09^th, 2023    Expiry date: Feb., 07^th, 2025

Storage: Well-closed store in cool and dry place

Shelf life: 24 Months when properly stored.