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CAS 151533-22-1 L-5-Methyltetrahydrofolate Calcium Powder 99% Levomefolate Calcium Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Levomefolate calcium
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 151533-22-1 Mf: C20H23CaN7O6
MW: 497.52 Specification: 99%
Other Name: L-5-MTHF-Ca Appearance: Light Yellow Crystalline Powder
Sample: Available
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L-5-Methyltetrahydrofolate Calcium Powder


99% Levomefolate Calcium Powder


Supplements L-5-Methyltetrahydrofolate Calcium

Product Description

CAS 151533-22-1 L-5-Methyltetrahydrofolate Calcium Powder 99% Levomefolate Calcium Powder

CAS 151533-22-1 L-5-Methyltetrahydrofolate Calcium Powder 99% Levomefolate Calcium Powder 0

Product name

Levomefolate calcium


Light yellow crystalline powder








Keep in cool dry place.

CAS 151533-22-1 L-5-Methyltetrahydrofolate Calcium Powder 99% Levomefolate Calcium Powder 1


The Introductction of Levomefolate Calcium


Levomefolate Calcium, also known as Calcium l-5-methyltetrahydrofolate (5-mthf) belongs to the folic acid group of vitamins (vitamin B9, folic acid), which is a coenzyme form of folic acid. , a naturally occurring salt-forming methyl derivative form of folic acid. 5-mthf, also known as levomethacrylic acid, is the most biologically active and functional form of folic acid and is more readily absorbed than regular folic acid.

Deficiency of folic acid is usually due to vitamin deficiency resulting in inadequate absorption, increased need for folic acid during pregnancy and lactation, child growth, altered absorption or metabolism, or medications. The consumption of folic acid-rich foods does not guarantee the dose provided under the influence of drugs and therefore requires supplementation.

Deficiency of folic acid reduces the ability of cells to synthesize and repair DNA, and supplementation may be a more beneficial way to increase folic acid to lower homocysteine levels and support normal cell proliferation, vascular endothelial function. Cardiovascular disease, neurological function, and especially during pregnancy supplementation with 5-MTHF has been shown to reduce the risk of developing neural tube abnormalities and recurrence.


The Application & Function of Levomefolate Calcium


Calcium L-5-methyltetrahydrofolate, also known as calcium 6S-5-methyltetrahydrofolate, CAS No.: 151533-22-1.


L-5-methyltetrahydrofolate (along with vitamin B12) functions as a methyl donor in a range of metabolic and neurological processes, making it essential for many metabolic pathways in the body. l-5-methyltetrahydrofolate plays a critical role in methylation, converting homocysteine to methionine, producing 5-hydroxytryptamine and melatonin, and is indirectly involved in DNA synthesis.


Studies have shown that neural tube defects in women born prematurely are associated with an increased risk of miscarriage. This is why folic acid supplementation is now recommended before and during pregnancy, along with an increased intake of folic acid-rich foods.


L-5-methyltetrahydrofolate is the most powerful dietary folic acid. It is the only naturally occurring form in our bloodstream and is therefore a form of folic acid that is normally delivered to peripheral tissues for cellular metabolism. Many people do not know that folic acid is a synthetic form of the vitamin, which means that it is only found in fortified foods, and supplements. It is the most oxidized form of folic acid and does not have the coenzyme activity that the body needs. Therefore, it must be reduced and methylated in order to be metabolically active in the body. In cells, folic acid is reduced to the metabolically active "tetrahydrofolate" form.


Other Name of Levomefolate Calcium


Calcium levomefolate
L-5- Methyl leucovorin
L-Methylfolate, calcium
L-5-Methyltetrahydrofolate calcium
L-5-Methyltetrahydrofolate calcium
L-Methyltetrahydrofolate, calcium salt
L-5-Methyltetrahydrofolic acid, calcium salt
Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino
(S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid, calciuM salt


The COA of Levomefolate Calcium


Product Name Calcium L-5-methyltetrahydrofolate Cas No. 151533-22- 1
Batch Number 20201201 Molecular Formula C20H23CaN7O6
Manufacture Date Dec., 1st, 2022 Product Quantity 6850g
Retest Date Dec , 2024 Report Date Dec ,2nd, 2022
Executive Standard SM-004(MC)-CP-04 Storage Conditions shading,keep under seal


DESCRIPTION White to light yellow crystalline powder Conforms


(on anhydrous substance)

HNMR: [a]25D(C=1.5% in water) +39.7°
IDENTIFICATION HNMR should be identical with that of reference Conforms
HPLC: The retention time of the major peak in the chromatograme of Assay preparation corresponds to that in the chromatograme of the standard preparation,as obtained in the Assay Conforms


(on anhydrous substance)

7.0% ~ 8.5% 7.4%
D-5-METHYLFOLATE ≤ 1.0% No detected
RELATED COMPOUNDS Dimethyltetrahydrofolic acid ≤0. 15% 0. 10%
Single impurity ≤ 1.0% 0.64%
Total Impurites ≤2.5% 1.5%



Ethanol: NMT 5000ppm No detected
WATER ≤16.0% 13.9%
CHLORIDE (Cl) ≤0.5% Conforms
ARSENIC (As) ≤ 1ppm <1ppm
BORON ≤20ppm Conforms
HEAVY METALS NMT 20ppm Conforms
TOTAL PLATE COUNT ≤ 100cfu/g Conforms
YEAST AND MOLD ≤ 100cfu/g No detected
SALMONELLA Negative No detected
E.COLI Negative No detected
Purity(HPLC) >97.5% 98.5%
CONCLUSION This product is tested by SM-004( MC)-CP-04,the results are in compliance with the Specification.

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