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High Purity Chemical Lovastatin Powder CAS 75330-75-5

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Lovastatin
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 75330-75-5 MF: C24H36O5
MW: 404.54 Specification: ≥99%
Appearance: White Powder EINECS: 616-212-7
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Product Description

High Purity Chemical Lovastatin Powder CAS 75330-75-5


Production name  Lovastatin
CAS No. 75330-75-5
Appearance White powder
Molecular Formula 75330-75-5
Molecular Weight 404.540
Assay 99%

High Purity Chemical Lovastatin Powder CAS 75330-75-5 0High Purity Chemical Lovastatin Powder CAS 75330-75-5 1

The Introduction of Lovastatin  :


Lovastatin is a hexahydronaphthyl ester isolated from Aspergillus terreus cultures, an inactive lactone, which is active only after being hydrolyzed after oral administration, and has a strong competitive inhibitory effect on HMG-CoA reductase in the liver. HMG-CoA reductase is the rate-limiting enzyme for ab initio cholesterol synthesis in vivo, and inhibition of this enzyme blocks the conversion of HMG-CoA to methyl valeric acid, resulting in a significant decrease in cholesterol synthesis and causing enhanced expression of hepatic LDL receptors, resulting in enhanced clearance of plasma LDL-C. The reduction in cholesterol synthesis also leads to a reduction in hepatic synthesis of ApoB100 and thus VLDL synthesis. Clinical observation shows that this product has good effect on lowering plasma total cholesterol and LDLC regardless of the various causes of hypercholesterolemia such as heterozygous familial hypercholesterolemia, polygenic hypercholesterolemia, diabetes mellitus or nephrotic syndrome.


The Application & Function of Lovastatin :


1. Lovastatin for cardiovascular system drugs to stop the development of atherosclerosis and reduce the risk of myocardial infarction, etc.

2. Cholesterol-lowering drug and competitive inhibitor of HMG-CoA reductase, a rate-limiting enzyme for cholesterol synthesis. Blocks the production of mevalonate, a key compound for cholesterol and isoprene production. This product is a substrate for Pgp and CYP3A. It increases cellular resistance to anti-cancer drugs, such as adriamycin, and induces apoptosis in myeloma cells. The product induces apoptosis in numerous cancer cells, in part by inhibiting Rho family GTPases. It causes the cell cycle to be captured in the G1 and G2/M phases.



High Purity Chemical Lovastatin Powder CAS 75330-75-5 2High Purity Chemical Lovastatin Powder CAS 75330-75-5 3High Purity Chemical Lovastatin Powder CAS 75330-75-5 4

Contact Details
Haylee Wang

Phone Number : +8615399065181

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