Pharmaceutical 99% Bismuth Potassium Citrate Raw Material Powder CAS 57644-54-9

Pharmaceutical 99% Bismuth Potassium Citrate Raw Material Powder CAS 57644-54-9

The Introductction of Bismuth Potassium Citrate

Bismuth potassium citrate is a white powder, salty, moisture-attracting, very soluble in water, slightly soluble in ethanol.

Potassium bismuth citrate, a drug for gastric and duodenal ulcers, acts in a unique manner, neither neutralizing gastric acid nor inhibiting gastric acid secretion. It forms a solid bismuth oxide colloidal precipitate on the ulcer surface or ulcer granulation tissue, forming a protective film, thus isolating the erosive effect of gastric acid, pepsin and food on the ulcer mucosa and promoting the repair and healing of ulcer tissue. Bismuth potassium citrate is also used for compound ulcers, multiple ulcers, anastomotic ulcers and erosive gastritis. In combination with antibiotics, it can eradicate Helicobacter pylori. Used for H. pylori-related gastric and duodenal ulcers and chronic gastritis, gastric MALT lymphoma, early postoperative gastric cancer, gastroesophageal reflux disease and functional dyspepsia. It can also be used in a quadruple regimen with acid-secretory inhibitors (proton pump inhibitors and H2 receptor antagonists) as remedial therapy for failed H. pylori eradication.

Bismuth potassium citrate has a clear inhibitory effect on pepsin activity, but its ability to affect pepsin secretion is controversial and its neutralizing effect on gastric acid is weak. At present, it is believed that the effect of bismuth potassium citrate mainly works locally, and the specific mechanism is as follows: ① kill Helicobacter pylori (Hp), reduce the pathogenic effect of Hp; ② mucosal protective effect: enhance the mucus barrier, non-specifically inhibit Hp-containing protease, lipase and glycosidase: osmotic barrier effect, the product forms insoluble bismuth salts deposited on the gastric mucosa under acidic environment, and binds closely with protein It can form a protective film on the surface of ulcer, which can isolate the erosive effect of gastric acid and enzymes on ulcer, and can prevent the re-infiltration of hydrogen ion to the gastric mucosa with protective effect. Stimulates endogenous prostaglandin synthesis. Stimulates the secretion of bicarbonate. When this product is applied, it shows aggregation of epidermal growth factor in the ulcer area.

The Application & function of Bismuth Potassium Citrate

Bismuth potassium citrate is used as a stomach medicine to promote the regeneration of epithelial cells and kill H. pylori completely and permanently.

Bismuth Citrate Potassium is indicated for gastric ulcer, duodenal bulb ulcer, anastomotic ulcer, chronic gastritis, erosive gastritis, duodenitis, functional dyspepsia, gastric mucosal damage caused by non-steroidal anti-inflammatory drugs, and anti-H. pylori infection.

Other Name of Bismuth Potassium Citrate

de-nol
de-noltab
BISMUTH SUBCITRATE
duosol(ulcertreatment)
BISMUTH POTASSIUM CITRATE
Bismuth Potassium Citrate
tripotassiumdicitratobismuthate
Tripotassium Dicitrate Bismuthate

The COA of Bismuth Potassium Citrate