| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Levofloxacin hydrochloride |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, Western Union, MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 177325-13-2 | Mf: | C18H21ClFN3O4 |
|---|---|---|---|
| MW: | 397.83 | Specification: | 99% |
| EINECS No.: | 605-797-4 | Appearance: | White Crystalline Powder |
| Sample: | Available | ||
| High Light: | Levofloxacin Hydrochloride Pharmaceutical Grade Antibiotics,Levofloxacin Hydrochloride API Pharmaceutical |
||
Pharmaceutical Grade Antibiotics 99% Levofloxacin hydrochloride Powder CAS 177325-13-2
|
Product name |
Levofloxacin hydrochloride |
|
Appearance |
White Crystalline Powder |
|
CAS |
177325-13-2 |
|
MF |
C18H21ClFN3O4 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introductction of Levofloxacin hydrochloride
Levofloxacin hydrochloride is a white to light yellow crystalline powder, odorless and bitter in taste. It is slightly soluble in water, very slightly soluble in ethanol, insoluble in ether; soluble in glacial acetic acid, slightly soluble in 0.1mol/L hydrochloric acid solution.
Levofloxacin hydrochloride tablets are synthetic antibacterial drugs, belonging to the quinolone class of bactericidal agents, whose antibacterial mechanism is mainly to inhibit bacterial DNA gyrase and topoisomerase IV, inhibit the synthesis and replication of bacterial DNA to achieve the purpose of sterilization, with strong antibacterial effect, broad antibacterial spectrum, good oral absorption, long duration of action, wide distribution in vivo, high tissue concentration, and no cross-resistance with other antibacterial drugs.
Its main mechanism of action is to inhibit the activity of bacterial DNA rotase (bacterial topoisomerase II) and prevent bacterial DNA replication. It has the characteristics of wide antibacterial spectrum and strong antibacterial effect.
Levofloxacin hydrochloride has strong antibacterial activity against most Enterobacteriaceae, such as Escherichia coli, Klebsiella spp, Serratia spp, Aspergillus spp, Shigella spp, Salmonella spp, Citrobacter spp, Immunobacterium spp, as well as Pseudomonas aeruginosa, Haemophilus influenzae, gonorrhea and other gram-negative bacteria. It also has good antibacterial effect on some methicillin-sensitive Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus haemolyticus and other Gram-positive bacteria and Legionella, Mycoplasma and Chlamydia. However, it has poor effect on anaerobic bacteria and enterococci.
The Application & Levofloxacin hydrochloride
Levofloxacin hydrochloride is indicated for the following mild, moderate and severe infections of the respiratory system caused by sensitive bacteria: acute bronchitis, chronic bronchitis, acute exacerbation of chronic bronchitis, diffuse fine bronchitis, bronchiectasis co-infection, pneumonia, pharyngitis, tonsillitis (peri-tonsillar abscess).
Levofloxacin hydrochloride is indicated for urinary system infections: pyelonephritis, complicated urinary tract infections, etc. Reproductive system infections: prostatitis, epididymitis, uterine infection, uterine adnexitis, pelvic inflammatory disease (metronidazole may be used in combination with suspected anaerobic bacterial infection).
Levofloxacin hydrochloride is indicated for skin and soft tissue infections: infectious impetigo, cellulitis, lymphadenitis, subcutaneous abscess, perianal abscess, etc.
Levofloxacin hydrochloride is indicated for intestinal infections: bacterial dysentery, infectious enteritis, Salmonella spp. enteritis, typhoid and paratyphoid fever, etc.
Levofloxacin hydrochloride is indicated for other infections: trauma
Other Name of Levofloxacin hydrochloride:
(3S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacidmonohydrochloride;LEVOFLOXACINHYDROCHLORIDE;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid,9-fluoro-2,3-dihydro-3-Methyl-10-(4-Methyl-1-piperazinyl)-7-oxo-,hydrochloride(1:1),(3S)-;3S)-9-Fluoro-2,3-dihydro-3-Methyl-10-(4-Methyl-1-piperazinyl)-7-oxo-Chemicalbook7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacidMonohydrochlori;(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylicacidhydrochloride;-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylicacidhydrochloride;-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl);usp2799%LevofloxacinwhitepowderAntibacterial
The COA of Levofloxacin hydrochloride
Product Name: Levofloxacin hydrochloride
Batch Number: HNB220908
| Batch Quantity: 500kg |
|
Manufacture Date: Sep., 11th, 2022 Analysis Date: Sep., 10th,2022 Expiry Date:Sep.,09th,2025 |
| Storage: Store in cool & dry place. Store in well-closed containers. |
| Shelf life: 3 Years when properly stored. |
| ITEMS OF ANALYSIS | SPECIFICATIONS | RESULT |
| Appearance | White crystalline powder | Complies |
| Clarity and color of the solution | The solution should be clarified, if turbid, compared with No. 1 turbidity standard solution, shall not be more concentrated; if colorful, compared with yellow or yellow-green No. 4 standard solution, shall not be darker. | Complies |
| Assay by HPLC(dry base) | 89.5% to 92%(C19H22FN3O3) | 90.2% |
| Identification | HPLC: The retention time of major peak of the sample solution corresponds to that of the standard solution, as obtained in the Assay. | Complies |
| IR: Conforms to the spectrum of the standard RS. | Complies | |
| Responds to the tests for chloride | Complies | |
| pH | 3.5~4.5(25mg/ml solution in water) | 3.8 |
| Water | 4.7%~6.7% | 5.9% |
| Residue on ignltion | ≤0.2% | 0.04% |
| Heavy metals | ≤20ppm | <20ppm |
| Loss on drying | ≤1.0% | <0.09% |
| Related Substances | Fluoroquinolonic acid: ≤0.2% | 0.09% |
| Ciprofloxacin : ≤0.5% | 0.25% | |
| Impurities | Any other individual impurity: ≤0.3% | 0.18% |
| Total impurities:≤0.7% | 0.51% | |
| Conclusion | Complied with the USP43 standard | |
