Cas 70288-86-7 Veterinary API 99% Ivermectin Powder Antiparasitics

Cas 70288-86-7 Veterinary API Antiparasitics 99% Ivermectin Powder

The Introductction of Ivermectin

Ivermectin is a semi-synthetic macrolide multi-component antibiotic produced by the fermentation of Streptomyces avermitilis. Mainly contains ivermectin B1 (Bla + B1b ) not less than 93%, of which Bla must not be less than 85%.

Ivermectin is a macrolide antibiotic with a sixteen-membered ring, whose basic structure is a macrolide ring at the carbon 16 position and three major substituent groups, namely hexahydrobenzofurans at the C2 to C8 positions, a disaccharide group at the C13 position, and a ketone group at the C17 to C18 positions.

Ivermectin is white or slightly yellow crystalline powder, soluble in methanol, esters and aromatic hydrocarbons, insoluble in water. Solubility in water is about 4ug/mL. very soluble in methyl ethyl ketone, propylene glycol or polypropylene glycol, insoluble in saturated hydrocarbons, such as cyclohexane.

The pharmacokinetics of ivermectin varies significantly depending on the species, dosage form and route of administration. In terms of plasma half-life, for example, although the t1/2 of 300 μg/kg doses given intravenously to cattle and sheep differed little (2.8 and 2.7 days, respectively), the lower plasma concentration in sheep was due to a larger apparent volume of distribution than in cattle. Ivermectin was excreted more rapidly in dogs (t1/2 = 1.6 to 1.8 days). In pigs, the half-life is up to 4 days.

The Application & Function of Ivermectin

Ivermectin is widely used for gastrointestinal nematodes, lung nematodes and parasitic arthropods in cattle, sheep, horses and pigs, intestinal nematodes, ear mites, scabies mites, heartworm and microfilariae in dogs, and gastrointestinal nematodes and ectoparasites in poultry.

Other Name of Albendazole: 

Ivermecti;mk933;22,23-dihydroavermectin B1;Uvemec;Ivosint;Ivermectin;EQVALEN;IVOMEC;

CARDOMECmk-0933;Mectizan;Vermic;

The COA of Ivermectin