|Place of Origin:||China|
|Minimum Order Quantity:||1KG|
|Packaging Details:||Aluminum foil bag|
|Payment Terms:||L/C, D/A, D/P, T/T, Western Union, MoneyGram，Alibaba Assurance Order|
|Einecs No.:||274-536-0||Appearance:||White Crysalline Powder|
99% Ivermectin Powder,
Cas 70288-86-7 Veterinary API,
Ivermectin Powder Antiparasitics
Cas 70288-86-7 Veterinary API Antiparasitics 99% Ivermectin Powder
The Introductction of Ivermectin
Ivermectin is a semi-synthetic macrolide multi-component antibiotic produced by the fermentation of Streptomyces avermitilis. Mainly contains ivermectin B1 (Bla + B1b ) not less than 93%, of which Bla must not be less than 85%.
Ivermectin is a macrolide antibiotic with a sixteen-membered ring, whose basic structure is a macrolide ring at the carbon 16 position and three major substituent groups, namely hexahydrobenzofurans at the C2 to C8 positions, a disaccharide group at the C13 position, and a ketone group at the C17 to C18 positions.
Ivermectin is white or slightly yellow crystalline powder, soluble in methanol, esters and aromatic hydrocarbons, insoluble in water. Solubility in water is about 4ug/mL. very soluble in methyl ethyl ketone, propylene glycol or polypropylene glycol, insoluble in saturated hydrocarbons, such as cyclohexane.
The pharmacokinetics of ivermectin varies significantly depending on the species, dosage form and route of administration. In terms of plasma half-life, for example, although the t1/2 of 300 μg/kg doses given intravenously to cattle and sheep differed little (2.8 and 2.7 days, respectively), the lower plasma concentration in sheep was due to a larger apparent volume of distribution than in cattle. Ivermectin was excreted more rapidly in dogs (t1/2 = 1.6 to 1.8 days). In pigs, the half-life is up to 4 days.
Ivermectin is widely used for gastrointestinal nematodes, lung nematodes and parasitic arthropods in cattle, sheep, horses and pigs, intestinal nematodes, ear mites, scabies mites, heartworm and microfilariae in dogs, and gastrointestinal nematodes and ectoparasites in poultry.
|Product Name||Ivermectin||Batch No||2021061201||Quantity||750kgs|
|Manufacturing Time||Sep.12.2022||Expiry Date||Sep.12.2024||Test Date||Sep.,12,2022|
|Appearance||While or yellowish-white crystalline powder||Qualified|
Practically insoluble in water. freely soluble inmethylene
chloride, soluble in alcohol (96%)
|IR||Corresponds with that of CRS standard||Qualified|
|The retention time for H2Bla and H2B1b corresponds with that of standard preparation||
|Appearance of solution||Clear and not more intensely colored than BY7||Qualified|
Specific optical rotation (anhydrous and
Related substances (%)
|Individual impurities(RRTI.3-1.5)≤2.5||l-l:<0.05; K:2.l|
Any other individual impurities≤l
C:0.07 A:027 J:0.20 H:0. 16 D:0.08 F: 0.07
|Disregard limit ≤0.05||0.05|
Ethanol and Formamide(%)
|Sulphated ash (%)||≤0.1||0.08|
|(HPLC. On dry basis)||95.0≤H2B1a+H2B1b≤102.0||96.1|
|Conclusion||Conforms With USP40|