| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Ivermectin |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually 7-10days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram |
| Supply Ability: | 5000kg/Month |
| CAS: | 70288-86-7 | Mf: | C48H74O14 |
|---|---|---|---|
| MW: | 875.09 | Specification: | 98%-99% |
| Einecs No.: | 274-536-0 | Appearance: | White Or Yellowish-white Crystalline Powder |
| High Light: | 99% Ivermectin Veterinary API,CAS 70288-86-7 Veterinary API,Antibiotic Ivermectin Powder |
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Ivermectin 99% Veterinary API CAS 70288-86-7
| Product Name | Ivermectin |
| CAS | 70288-86-7 |
| Molecular formula | C48H74O14 |
| Molecular weight | 875.09300 |
| Grade | Pharmaceutical Grade |
| Color | White powder |
| Purity | 99% |
| Shelf life | 2 years |
The Introductction of Ivermectin:
Ivermectin is a new broad-spectrum, high-efficiency, low-toxicity antibiotic antiparasitic drug, which has a good killing effect on internal and external parasites, especially nematodes and arthropods. But it is ineffective against tapeworms, flukes and protozoa. The repelling effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the release of the inhibitory transmitter γ-aminobutyric acid (GABA) of the worms, and to open the Cl ion channel controlled by glutamate, Enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, eventually nerve paralysis, so that muscle cells lose the ability to contract, resulting in the death of the worm.
English name: Ivermectin
English alias: Ivermecti;mk933;22,23-dihydroavermectin B1;Uvemec;Ivosint;Ivermectin;EQVALEN;IVOMEC;
CARDOMECmk-0933;Mectizan;Vermic;
CAS number: 70288-86-7
Molecular formula: C48H74O14
Molecular weight: 875.09300
Exact Mass: 874.50800
PSA: 170.06000
The Application & Function of Ivermectin:
1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.
2. Ivermectin has effect for most of the various life cycle nematodes.
3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.
5. Ivermectin has selective inhibition.
6. Ivermectin can not go through the blood brain barrier of humanbeings.
In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.
Ivermectin is widely used in gastrointestinal nematodes, lung nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes in dogs, ear mites, scabies mites, heartworms and microfilariae, and poultry stomach Gut nematodes and ectoparasites.
This product is a derivative of avermectin, which is an oral semi-synthetic broad-spectrum antiparasitic drug. This product is effective against most (but not all) nematodes of various life cycles; it is effective against microfilariae of Onchocerciasis, but not adults; it is also effective against strongyloides only in the intestinal tract. This product has a selective inhibitory effect. It binds with high affinity to chloride ion channels with glutamate as the valve in the nerve cells and muscle cells of non-vertebral animals, resulting in an increase in the permeability of the cell membrane to chloride ions, causing nerve cells or muscles. The cells hyperpolarize, paralyzing or dying the parasite. It also interacts with chloride channels of other ligand valves, such as the neurotransmitter g-aminobutyric acid (GABA). The selectivity of this product is due to the absence of glutamate-chloride channels in some mammals and the low affinity of abamectin for mammalian ligand-chloride channels. This product cannot penetrate the human blood-brain barrier. Onchocerciasis and strongyloidiasis and hookworm, roundworm, whipworm, pinworm infection.
The COA of Ivermectin:
| Tests | Specification | Results | |
| Appearance | White or yellowish-white crystalline powder, slightly hygroscopic. | Yellowish-white crystalline powder, slight hygroscopic. | |
| Solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol. | Qualified | |
| Identification | IR | Corresponds to that of CRS standard | Qualified |
| HPLC | The retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparation | Qualified | |
| Appearance of solution | Clear and not more intensely colored than BY? | Clear | |
| Specific optical rotation (anhydrous and solvent-free substance), ° | -20--17 | -17.9 | |
| Related substances (%) | Individual impurity(RRT 1.3-1.5)≤2.5 | I-l:<0.05 K:2.1 | |
| Any other impurity ≤ 1 | C:0.06 A:0.57 J:0.14 H:0.39 D:<0.05 F:<0.05 E:0.36 1-2:0.19 |
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| Total ≤5 | 3.8 | ||
| Disregard limit: 0.05 | |||
| Ethanol and Formamide (%) | Ethanol ≤5.0 | 3.9 | |
| Formamide≤3.0 | 2.5 | ||
| Catalyst (ug/g) | ≤1 | <1 | |
| Water (%) | ≤1.0 | 0.26 | |
| Sulphated ash (%) | ≤0.1 | 0.07 | |
| Heavy Metal (%) | ≤0.002 | <0.002 | |
| Assay (%) (HPLC, on dry basis) | H2Bla/(H2Bla +H2Blb)≥90.0 | 97.7 | |
| 95.0≤H2Bla +H2Blb≤ 102.0 | 96.7 | ||
| Conclusion | Complies with the requirements of EP10.0 | ||
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