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CAS 22832-87-7 Pharmaceutical API 99% Miconazole Nitrate Powder Antifungals

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Miconazole nitrate
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 22832-87-7 Mf: C18H15Cl4N3O4
MW: 479.14 Specification: 99%
EINECS: 245-256-6 Appearance: White To Off-white Crysatlline Powder
Sample: Available
High Light:

Pharmaceutical Miconazole Nitrate Powder

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Miconazole Nitrate Powder Antifungals

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CAS 22832-87-7 Pharmaceutical API


Product Description

Antifungals pharmaceutical API 99% Miconazole nitrate powder CAS 22832-87-7

CAS 22832-87-7 Pharmaceutical API 99% Miconazole Nitrate Powder Antifungals 0

Product name

Miconazole nitrate

Appearance

White to off-white Crystalline Powder

CAS

22832-87-7

MF

C18H15Cl4N3O4

Purity

99%

Storage

Keep in cool dry place.

 

CAS 22832-87-7 Pharmaceutical API 99% Miconazole Nitrate Powder Antifungals 1

The Introductction of Miconazole nitrate

 

Miconazole nitrate is a synthetic 1-phenethylimidazole derivative, which belongs to the imidazole class of broad-spectrum antifungal drugs and is a common drug for the treatment of dermatophytosis without hormones and without side effects, and its main active ingredient is miconazole.


The antibacterial spectrum, antibacterial activity and mechanism of action of miconazole nitrate are similar to that of clotrimazole.

Miconazole nitrate can be used as an alternative to amphotericin B when it is ineffective in the treatment of deep fungal infections.
Miconazole nitrate is suitable for the treatment of systemic and disseminated infections caused by fungi such as Cryptococcus neoformans and Pseudomonas albicans. It is poorly absorbed orally and stays mainly in the lesion after topical application, with little absorption into the body. It can penetrate into the inflamed joints, vitreous humor and peritoneum, but the concentration in sputum and saliva is low, and the blood-cerebrospinal fluid barrier is poorly penetrated, so it does not easily cross the blood-brain barrier. The plasma protein binding rate is 90%. Mainly inactivated by hepatic metabolism to inactive metabolites. 14%-22% of metabolites are excreted in urine, of which less than 1% are in the original form of the drug. 50% are excreted in the original form from the feces. Half-life α-phase is about 0.4 hours, half-life β-phase is about 2.1 hours, terminal half-life is 20-24 hours.

 

The Application & Miconazole nitrate

 

Miconazole nitrate has good antibacterial effect on a variety of deep fungi (such as Candida albicans, Aspergillus, Cryptococcus neoformans, Bacillus, Coccidioides, Yeast mimics), certain epidermal fungi and yeasts. It also has antibacterial effect on Gram-positive cocci (such as Staphylococcus, Streptococcus) and bacilli (such as Bacillus anthracis).


Clinical application
1. Miconazole nitrate is used for serious infections caused by Candida spp. including peritonitis, pneumonia and urinary tract infections.
Miconazole nitrate can also be used for secondary infections caused by gram-positive bacteria.2. Topical administration can be used for chronic widespread cutaneous mucosal candidiasis, Candida vulvovaginitis, ringworm, ringworm of the hands, ringworm of the femur, ringworm of the feet, lichen planus, fungal nail infection caused by dermatophytes, yeasts and many other fungi.3. Intravenous administration can be used for severe cryptococcosis, coccidioidomycosis, paracoccidioidomycosis, etc.

 

Other Name of Miconazole nitrate:  

 

monistat;Isoconazole IMpurity C Nitrate (Miconazole Nitrate);Ecobi;Vodol;Daktar;Florid;Aflorix;Brentan;Hi-Pick;Micatin

 

The COA of Miconazole nitrate

 

Product Name: Miconazole Nitrate (USP41)

CAS No.:22832-87-7

Batch No.: HNB20220808

Manufacture Date: Aug., 08th, 2022 Analysis Date: Aug., 09th, 2022 Expiry date: Aug.., 07th, 2024

Storage: Well sealed in cool and dry place

Shelf life: 24 Months when properly stored.

 

ITEMS SPECIFICATIONS RESULT
Appearance White either type white crystal powder Complies
Identification A,B complies with the standard Complies
Residue on ignition ≤ 0.2% 0.08%
Organic impurities Single impurity:≤ 0.25% 0.13%
Total other impurities: ≤ 0.5% 0.22%
Residual solvent Acetone ≤ 0.5% 0.03%
Ethanol ≤ 0.5% 0.02%
Loss on drying ≤ 0.5% 0.3%
Chloride ≤ 0.09% 0.008%
Heavy metals ≤ 10ppm Complies
As ≤ 2ppm Complies
Assay(on dried basis) 98.0%~102.0% 99.2%
Conclusion This product complies with USP41 Standard

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