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API Pharmaceutical Dimethylamino Antipyrine Aminophenazone

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO coa
Model Number: HNB Aminophenazone
Minimum Order Quantity: 1kg
Price: 30
Packaging Details: 25kg
Delivery Time: 5-10
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 50000
Detail Information
Product Name: Aminophenazone MF: C13H17N3O
Whatsapp: +86 152 029 61574
High Light:

Dimethylamino Antipyrine Aminophenazone API Pharmaceutical

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CAS 58-15-1 API Pharmaceutical

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API Aminophenazone Powder


Product Description

API Pharmaceutical Dimethylamino Antipyrine Aminophenazone

Aminopyrine Structure

Product Name: 4-DiMethylaMino Antipyrine
Synonyms: 2-dihydro-4-(N.,N-dimethylamino-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;4-Dimethylamino-2,3-dimethyl-1-phenyl pyrazol-1-one, 97%;4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Aminopyrine;Amidozon;Aminofebrin;Aminopyrazolin;4-(Dimethylamino)antipyrine, 98+%;4-Dimethylaminoantipyrine,97%
CAS:  
MF: C13H17N3O
MW: 231.29
EINECS: 200-365-8

API Pharmaceutical Dimethylamino Antipyrine Aminophenazone 1

whatsapp:+86 15202961574

What is aminophenazone ?

Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis.
White or almost white crystalline powder; odorless, slightly bitter taste; case of light variable quality; aqueous solution alkaline reaction.

Function:
Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.


Application:
Aminopyrine as antipyretic analgesic anti-inflammatory drug pyrazole ketones, inhibit the synthesis of prostaglandin E1 in the front of the hypothalamus neurons and release, to restore the normal reaction of the temperature regulating center feeling neurons and antifebrile effect; Amidopyrine also inhibit inflammation in local tissue of prostaglandin synthesis and release, stabilize lysosomal membrane, influence the phagocytosis of phagocytic cells, and have anti-inflammatory effect.

 

[Usage and Dosage] Oral administration. Take one tablet three times a day or as directed by your doctor.

[Adverse Reactions] Aminopyrine contained in this compound had obvious adverse reactions. Taking Aminopyrine can have vomiting, rash, fever, sweating and stomatitis, a few can cause neutrophilia, aplastic anemia, exudative erythema, exfoliative dermatitis, glans erosion, etc..

1. It is contraindicated for people allergic to aminopyrine, caffne and chlorphenyl maleate.

2. It is contraindicated in patients with gastric ulcer. It is forbidden for newborns or premature infants.

1. Long-term use of Aminopyrine can lead to renal damage, renal nipple necrosis or uremia in severe cases, and may even induce renal pelvis cancer and bladder cancer.

2. Aminopyrine in the stomach acid and food action, can form carcinogenic nitroso compounds, especially nitrosamine, so there is a potential carcinogenicity.

3. Aminopyrine should not be used for a long time to avoid the occurrence of neutrophilic deficiency. If the drug is used for more than 1 week, the blood image should be checked regularly.

4. Long-term use can lead to dependence and tolerance.

5. It is ineffective for all kinds of traumatic pain and visceral smooth muscle colic.

6. This product should not be used in patients with lower respiratory tract infections and asthma attacks (it may worsen the disease by thickening the sputum).

7. Cross allergy. People who are allergic to other antihistamines or the following drugs may also be allergic to this product, such as ephedne, epinephne, isoproterenephrine, methydroxyisoproterenerine, noradrenaline and other sympathetic drugs. People who are allergic to iodine may also be allergic to this product.

8. Use with caution in the following cases: bladder neck obstruction, pyloric and duodenal obstruction, pyloric stricture caused by peptic ulcer, cardiovascular disease, glaucoma (or those with glaucoma tendency), hypertension, hypertensive crisis, hyperthyroidism, or obvious signs of prostatic hypertrophy.

9. It is not suitable for people who drive motor vehicles, operate machinery and work at high altitude.

[Aminopyrine Drug interactions]

1 Isoniazid and methalamine can promote the synergistic effect of cafeine, increasing the concentration of the latter in the brain tissue by 55%, while decreasing the concentration in the liver and kidney. Oral contraceptives may slow caffine clearance.

3 at the same time drinking alcohol or taking central nervous inhibition drugs, can promote antihistamine effect enhancement.

4 This product can enhance the effects of amantadine, anticholinergic, haloperidol, phenecinins and sympathetic drugs. Quinidine is used with this product and its atropine-like effects are intensified. When taken together with tricyclic antidepressants, the effects of the latter can be enhanced.

 

[Pharmacological Effects]

Aminopyrine in this product can inhibit the synthesis and release of hypothalamus prostaglandin, restore the normal response of sensory neurons in the central body temperature regulation and play an antipyretic role; At the same time also through the inhibition of prostaglandin synthesis and analgesic effect. Aminopyrine can inhibit the synthesis and release of prostaglandin in inflammatory local tissues, stabilize lysosomal enzymes, affect the phagocytosis of phagocytes and play an anti-inflammatory role. Acetaminon is a peripheral analgesic. The mechanism of action is to regulate the synthesis and release of central prostaglandin (PGE1) by inhibiting hypothalamus body temperature, resulting in peripheral vasodilation, causing sweating to achieve antipyretic effect, and at the same time can inhibit the effects of PGE1, bradykinin and histamine, improve the pain threshold and produce analgesic effect. Because of the central nervous excitant, coffee can stimulate the cerebral cortex, improve the sensitivity to the outside world, and has the contraction of cerebrovascular, strengthen the first two drugs to relieve the effect of headache. Chlorpheniramine maleate has a strong histamine H1 receptor blocking effect, can relieve other respiratory symptoms caused by allergies, and has a mild inhibitory effect on the central nervous system.

API Pharmaceutical Dimethylamino Antipyrine Aminophenazone 2

Contact Details
Gary Liu

Phone Number : +8615202961574

WhatsApp : +8618629242069