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84371-65-3 API Pharmaceutical 99% Raw Mifepristone Powder Antiprogestins

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Mifepristone
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 84371-65-3 Mf: C29H35NO2
MW: 429.6 Specification: 99%
Grade: Medicine Grade Appearance: Light Yellow Crystalline Powder
Sample: Available
High Light:

Mifepristone Powder Antiprogestins

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Raw Mifepristone Powder

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Mifepristone API Pharmaceutical


Product Description

84371-65-3 API Pharmaceutical 99% Mifepristone Powder Antiprogestins Raw Powder

84371-65-3 API Pharmaceutical 99% Raw Mifepristone Powder Antiprogestins 0

Product name

Mifepristone

Appearance

Light yelllow crystalline powder

CAS

84371-65-3

MF

C29H35NO2

Purity

99%

Storage

Keep in cool dry place.

84371-65-3 API Pharmaceutical 99% Raw Mifepristone Powder Antiprogestins 1

 

The Introductction of Mifepristone

 

Mifepristone, also known as RU-486, antiprogesterone, restbacitol, restain, containzubut, simethicone, minasone, is an antiprogesterone drug that also has anti-glucocorticoid activity without progesterone, androgenic, estrogenic or anti-estrogenic activity.


Mifepristone mainly acts on endometrial progesterone receptors, which can bind to progesterone receptors and glucocorticoid receptors with high affinity. The affinity for endometrial progesterone receptors is 5 times stronger than that of progesterone, and has no significant effect on cortisol levels at effective doses. It can produce strong anti-progesterone effects, causing metaplastic and chorionic tissue degeneration of pregnancy and endogenous prostaglandin release, resulting in uterine contraction, and also It also decreases the production of human chorionic gonadotropin and lyses the corpus luteum, thus causing the embryo to abort.


Mifepristone does not trigger sufficient uterine activity and has a high rate of incomplete abortion when used alone against early pregnancy, but it increases the sensitivity of the uterus to prostaglandins, so the addition of small doses of prostaglandins can both reduce the adverse effects of prostaglandins and significantly increase the rate of complete abortion. In addition mifepristone has the effect of softening and dilating the cervix.


Precautions.

1. contraindicated in cases of heart, liver and kidney diseases and adrenal cortical insufficiency, hypertension, pregnancy with intrauterine device, suspected ectopic pregnancy.
2. For incomplete or invalid abortion, abortion by negative pressure aspiration is required. avoid use in pregnant women over 35 years of age. The use of this drug should be followed up 8 to 12 days after administration to check for complete abortion or cessation of bleeding. 3. Follow up 8 to 12 days after use to check for complete abortion or cessation of bleeding.
3. Cannot be combined with rifampin, carbamazepine, ashwagandha, barbiturates, phenytoin sodium, non-steroidal anti-inflammatory drugs, and adrenocorticosteroids.
4. Can not be combined with salicylates, indomethacin and other analgesics.
5. For those who bleed for a long time, antibiotics and uterine contraction agents should be added to prevent infection. It is prohibited for those with heart, liver and kidney diseases and adrenal cortical insufficiency.
6. Mifepristone should be kept away from light and airtight.
7. 8 to 15 days after taking the drug should go to the medical unit for follow-up; if the abortion is incomplete or continues, the pregnancy should be terminated by abortion.

 

 

The Application & Function of Mifepristone

 

Mifepristone is used as a novel anti-progestational hormone and has anti-glucocorticoid activity without progestational, estrogenic, androgenic or anti-estrogenic activity. The affinity with progesterone receptors is 5 times stronger than progesterone.

Mifepristone is used for anti-early pregnancy, inducing menstruation and stopping pregnancy, and inducing labor in fetal death.

 

Other Name of Mifepristone:

 

ra-4,9-dien-3-one;

ru486-6;

MIFEGYNE;

MIFEPRISTONE;

RU-38486;

RU486;

11BETA-[4-(DIMETHYLAMINO)PHENYL]-17BETA-HYDROXY-17-(1-PROPYNYL)ESTRA-4,9-DIEN-3-ONE;(11BETA,17BETA)-11-(4-(DIMETHYLAMINO)PHENYL)-17-HYDROXY-17-(1-PROPYNYL)ESTRA-4,9-DIEN-3-ONE

 

The COA of Mifepristone

 

CAS No.: 84371-65-3

Batch No.: HNB20220412

Manufacture Date: Apr., 12th, 2022   Analysis Date: Apr., 13th, 2022   Expiry date: Apr., 11th, 2024

Storage: Store in cool&dry place, in well-closed containers.

Shelf life: 24 Months when properly stored.

 

 

ITEMS SPECIFICATIONS RESULT
Appearance Light yellow Crystalline Powder Complies
Identification Positive Complies
Loss on drying ≤0.5% 0.22%
Residue on Ignition ≤0.5% 0.14%
Heavy metal ≤10ppm <10ppm
Total plate count ≤1000cfu/g <100cfu/g
Yeast & Molds ≤100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies
Assay ≥98% 99.58%
Conclusion This product complies with the Standard

Contact Details
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