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Autumnale Extract 98% Colchicine Powder CAS 64-86-8

Basic Information
Place of Origin: China
Brand Name: BCB
Certification: ISO
Model Number: Colchicine
Minimum Order Quantity: 1
Price: 20/g
Packaging Details: 1kg/bag, 25kg/drum
Delivery Time: 7 working days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram
Supply Ability: 10000kg/month
Detail Information
Purity: 99% Mf: C22h25no6
Cas No.: 64-86-8 Appearance: Yellow Powder
Usage: Pharmaceutical Intermediates Shelf Life: 24 Month
Molecular Weight: 399.437 Test Method: HPLC
Boiling Point: 726.0±60.0 °C At 760 MmHg

Product Description

Autumnale Extract 98% Colchicine Powder CAS 64-86-8

 

Prodcut name Colchicine
MOQ 10 gram
CAS No. 64-86-8
Appearance Yellow powder
Molecular Formula C22h25no6
Molecular Weight 399.437
Assay 99%
Application Pharma grade

 

Autumnale Extract 98% Colchicine Powder CAS 64-86-8 0

 

The Introductction of Colchicine:

 

Colchicine is one of a group of macrocyclic alkaloids. Chemical formula: C22H23NO6. It is commonly found in the liliaceae plants of Jialan and Lijiangshan, with the content of 0.11% and 0.1%, respectively. Alkaloids, extracted from the plant colchicine, inhibit the formation of spindle filaments and thus delay the division of the centromere..

 

The Application & Function of Colchicine:

 

Function of colchicine

1. It is anti-gout, anti-tumor, inhibiting the mitotic cell stopping in M phase.
2.It has the significant effects on breast cancer, cervical cancer, esophageal cancer, lung cancer,gastric cancer and chronic    myelogenous leukemia.
3.It also can be used for acute gout, anti-inflammatory analgesic.
4.In recent years ,furtherly expand its clinical application, for example:to prevent atherosclerosis damage;to cure the liver cirrhosis; to relief the cycle heat caused by abnormal catecholamine, the Behcet's disease; the lumbar disc herniation,intractable waist pain and sciatica; prevent intestine adhesion.
5.In addition, its used as the treatment of Purple epilepsy caused thrombocytopenia; Persistent apophysis erythema;Advanced schistosomiasis;
6.Moreover, using colchicine three can get the polyploidy,so Colchicine is indispensable in chromosome research...


Application of colchicine

Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. In neurons, axoplasmic transport is disrupted by colchicine. .

 

It has anti-anxiety effect and few adverse reactions. Regulates the autonomic nervous system. In particular, the drug not only has an antagonistic effect on abnormal behavior caused by anxiety, but also has an effect on abnormal physiological and biochemical phenomena. Suitable for various physical and mental disorders caused by anxiety disorders

 

The COA of Colchicine :

 

ITEM SPECIFICATION RESULT METHOD
Appearance Light Yellow powder, neutral odor, highly hygroscopic Conforms Visual
Identification Standard solution and test solution same spot,RF Conforms TLC
Specific Optical -2.4°~ -2.8° -2.72°  
Heavy metals (as PB) ≤10ppm Conforms AAS
Sulfate (SO4) ≤0.02% Conforms Colorimetry
Chloride (Cl) ≤0.02% Conforms Colorimetry
Phosphate Ion (P) ≤5ppm Conforms Colorimetry
Residual solvent(ethanol) ≤1.0% Conforms HS-GC
pH 4.5~7.0 5.10  
Related substance Spot not bigger than standard solution spot No spot TLC
Water Content ≤2% 0.26% KF
Assay (dried basis) 98.0%--102.0% 99.48% Potentiometric titration
Assay (dried basis) 98.5%--100% 99.2% HPLC

 

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