Purity: | 99% | Mf: | C22h25no6 |
---|---|---|---|
Cas No.: | 64-86-8 | Appearance: | Yellow Powder |
Usage: | Pharmaceutical Intermediates | Shelf Life: | 24 Month |
Molecular Weight: | 399.437 | Test Method: | HPLC |
Boiling Point: | 726.0±60.0 °C At 760 MmHg |
Autumnale Extract 98% Colchicine Powder CAS 64-86-8
Prodcut name | Colchicine |
MOQ | 10 gram |
CAS No. | 64-86-8 |
Appearance | Yellow powder |
Molecular Formula | C22h25no6 |
Molecular Weight | 399.437 |
Assay | 99% |
Application | Pharma grade |
The Introductction of Colchicine:
The Application & Function of Colchicine:
Function of colchicine
1. It is anti-gout, anti-tumor, inhibiting the mitotic cell stopping in M phase.
2.It has the significant effects on breast cancer, cervical cancer, esophageal cancer, lung cancer,gastric cancer and chronic myelogenous leukemia.
3.It also can be used for acute gout, anti-inflammatory analgesic.
4.In recent years ,furtherly expand its clinical application, for example:to prevent atherosclerosis damage;to cure the liver cirrhosis; to relief the cycle heat caused by abnormal catecholamine, the Behcet's disease; the lumbar disc herniation,intractable waist pain and sciatica; prevent intestine adhesion.
5.In addition, its used as the treatment of Purple epilepsy caused thrombocytopenia; Persistent apophysis erythema;Advanced schistosomiasis;
6.Moreover, using colchicine three can get the polyploidy,so Colchicine is indispensable in chromosome research...
Application of colchicine
Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. In neurons, axoplasmic transport is disrupted by colchicine. .
The COA of Colchicine :
ITEM | SPECIFICATION | RESULT | METHOD |
Appearance | Light Yellow powder, neutral odor, highly hygroscopic | Conforms | Visual |
Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
Specific Optical | -2.4°~ -2.8° | -2.72° | |
Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
pH | 4.5~7.0 | 5.10 | |
Related substance | Spot not bigger than standard solution spot | No spot | TLC |
Water Content | ≤2% | 0.26% | KF |
Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
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