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CAS 969-33-5 Anti Allergy Powder 98% Cyproheptadine Hydrochloride Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Cyproheptadine Hydrochloride
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually3-5days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram,Alibaba Assurance Order
Supply Ability: 5000kg/Month
Detail Information
CAS: 969-33-5 Mf: C21H22ClN
MW: 323.86 Specification: 99%
Grade: Medicine Grade Appearance: White Crystalline Powder
Sample: Available

Product Description

CAS 969-33-5 Anti Allergy Powder 98% Cyproheptadine Hydrochloride Powder

CAS 969-33-5 Anti Allergy Powder 98% Cyproheptadine Hydrochloride Powder 0

Product name

Cyproheptadine Hydrochloride

Appearance

White crystalline powder

CAS

969-33-5

MF

C21H22ClN

Purity

99%

Storage

Keep in cool dry place.

CAS 969-33-5 Anti Allergy Powder 98% Cyproheptadine Hydrochloride Powder 1

 

The Introductction of Cyproheptadine Hydrochloride

 

Cyproheptadine hydrochloride, also known as dibenzocycloheptadine, antigentadine, is a hexahydropyridine antihistamine, which can compete with histamine released from tissues for H1 receptors on effector cells, thus preventing the onset of allergic reactions and relieving the spasmogenic and congestive effects of histamine, which has a strong H1 receptor antagonistic effect and stronger antihistamine effect than paracetamol and promethazine. It has mild to moderate anti-5-hydroxytryptamine effect and anticholinergic effect.

 

In addition, Cyproheptadine hydrochloride also has the effect of stimulating appetite, and weight gain can be seen after taking for a certain period of time.


Cyproheptadine hydrochloride is a white or yellowish crystalline powder, almost odorless, with a slightly bitter taste. It is soluble in methanol, dissolved in chloroform, slightly soluble in ethanol, slightly soluble in water and almost insoluble in ether.


Side effects of Cyproheptadine hydrochloride
1. Drowsiness or sleepiness, dry mouth, bitter mouth, sticky sputum, constipation, etc. may occur after administration. Rash, increased photosensitivity, hypotension, tachycardia, extrasystole, anaphylaxis, hemolytic anemia, leukopenia, thrombocytopenia, weakness, headache, insomnia, abnormal sensation, convulsions, hallucinations, hysteria and other adverse reactions have been reported.

2. Long-term use of the drug may lead to increased appetite and weight gain.

 

 

The Application & Function of Cyproheptadine Hydrochloride

 

Clinically, cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially cold urticaria has good effect), papular urticaria, angioedema, allergic eczema, contact dermatitis, food allergic reaction, drug allergic reaction, allergic rhinitis, hay fever, allergic nodular inflammation, insect sting allergy and migraine.


Cyproheptadine hydrochloride has some therapeutic effect on bronchial asthma. It can also be used as an adjuvant treatment for Cushing's syndrome and acromegaly.


Cyproheptadine hydrochloride can also be used as an appetite enhancer for neurotic appetite fear.


Cyproheptadine hydrochloride has also been reported for the treatment of acanthosis nigricans and the prevention of necrotizing pyoderma.

 

Other Name of Cyproheptadine Hydrochloride:

 

CYPROHEPTADINEHYDROCHLORIDE;

CYPROHEPTADINE HCL

CycloheptadineHydrochloride;

1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidinehydrochloride;

4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidinChemicalbookehydrochloride;

4-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-piperidinhydrochloride;

cyproheptadienehydrochloride;nuran;

4-(5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDINE)-METHYLPIPERIDINEHYDROCHLORIDE

 

The COA of Cyproheptadine Hydrochloride

 

Batch No.: HNB220303
Product Name: CYPROHEPTADINE HYDROCHLORID
CAS No.: 10592-13-9
Manufacture Date:Mar.,03th,2022 Analysis Date: Mar.,04th,2022 Expiry Date: Mar.,02nd,2022
Storage: Store in cool&dry place, in well-closed containers.
Shelf life: 24 Months when properly stored.

Certificate of Analysis

ITEMS OF ANALYSIS SPECIFICATIONS RESULT
Appearance

White to slightly yellow, odorless or

practically odorless, crystalline powder.

White Crystalline Powder
Identification IR:The infrared absorption spectrum of the potassium bromide dispersion of the sample exhibits maxima only at the same wavelengths as that of a similar preparation of Cyproheptadine Hydrochloride reference standard Complies
HPLC:The retention time of the cyproheptadine peak of the sample solution corresponds to that of the standard solution, as obtained in the test for organic impurities Complies
A saturated solution gives reaction of chlorides Complies
Solubility Freely soluble in methanol, sparingly soluble in chloroform, sparingly soluble in alcohol, slightly soluble in water practically insoluble in ether. Complies
Fluorescence Test To comply Complies
Residue of Ignition

≤ 0.1%

 

0.07%
Sulphated Ash ≤ 0.1% 0.08%
Light-absorbing impurities

At 490nm ≤ 0.07

 

0.04
Organic Impurities by HPLC Cyproheptadine related compound C: ≤ 0.15% Not detected
Amitriptyline related compound B ≤ 0.15% Not detected
Cyproheptadine related compound A ≤ 0.15% 0.05%
Any individual unknown Impurity ≤ 0.1% 0.05%
  Total impurities ≤0.5% 0.13%
Acidity

NMT 0.15 ml of 0.01 M sodium Hydroxide is

required to change the co lour of the indicator

 

0.1ml
Water Determination 7.0% to 9.0% 8.5%
Residual Solvents Methanol ≤300ppm 163ppm
O-rylene ≤2170ppm Not detected
lsopropyl alcohol ≤5000ppm 24ppm
Toluene ≤890ppm Not detected
Tetrahydrofuran ≤720ppm Not detected
Chloroform ≤60ppm Not detected
Assay (Dry based) 98.5%~100.5% 100.2%
Conclusion Complies with the USP40 standard

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