|Place of Origin:||China|
|Model Number:||Cyproheptadine Hydrochloride|
|Minimum Order Quantity:||1KG|
|Packaging Details:||Aluminum foil bag|
|Payment Terms:||L/C, D/A, D/P, T/T, Western Union, MoneyGram，Alibaba Assurance Order|
|Grade:||Medicine Grade||Appearance:||White Crystalline Powder|
CAS 969-33-5 Anti Allergy Powder 98% Cyproheptadine Hydrochloride Powder
The Introductction of Cyproheptadine Hydrochloride
Cyproheptadine hydrochloride, also known as dibenzocycloheptadine, antigentadine, is a hexahydropyridine antihistamine, which can compete with histamine released from tissues for H1 receptors on effector cells, thus preventing the onset of allergic reactions and relieving the spasmogenic and congestive effects of histamine, which has a strong H1 receptor antagonistic effect and stronger antihistamine effect than paracetamol and promethazine. It has mild to moderate anti-5-hydroxytryptamine effect and anticholinergic effect.
In addition, Cyproheptadine hydrochloride also has the effect of stimulating appetite, and weight gain can be seen after taking for a certain period of time.
Cyproheptadine hydrochloride is a white or yellowish crystalline powder, almost odorless, with a slightly bitter taste. It is soluble in methanol, dissolved in chloroform, slightly soluble in ethanol, slightly soluble in water and almost insoluble in ether.
Side effects of Cyproheptadine hydrochloride
1. Drowsiness or sleepiness, dry mouth, bitter mouth, sticky sputum, constipation, etc. may occur after administration. Rash, increased photosensitivity, hypotension, tachycardia, extrasystole, anaphylaxis, hemolytic anemia, leukopenia, thrombocytopenia, weakness, headache, insomnia, abnormal sensation, convulsions, hallucinations, hysteria and other adverse reactions have been reported.
2. Long-term use of the drug may lead to increased appetite and weight gain.
|Batch No.: HNB220303|
|Product Name: CYPROHEPTADINE HYDROCHLORID|
|CAS No.: 10592-13-9|
|Manufacture Date:Mar.,03th,2022 Analysis Date: Mar.,04th,2022 Expiry Date: Mar.,02nd,2022|
|Storage: Store in cool&dry place, in well-closed containers.|
|Shelf life: 24 Months when properly stored.|
|ITEMS OF ANALYSIS||SPECIFICATIONS||RESULT|
White to slightly yellow, odorless or
practically odorless, crystalline powder.
|White Crystalline Powder|
|Identification||IR:The infrared absorption spectrum of the potassium bromide dispersion of the sample exhibits maxima only at the same wavelengths as that of a similar preparation of Cyproheptadine Hydrochloride reference standard||Complies|
|HPLC:The retention time of the cyproheptadine peak of the sample solution corresponds to that of the standard solution, as obtained in the test for organic impurities||Complies|
|A saturated solution gives reaction of chlorides||Complies|
|Solubility||Freely soluble in methanol, sparingly soluble in chloroform, sparingly soluble in alcohol, slightly soluble in water practically insoluble in ether.||Complies|
|Fluorescence Test||To comply||Complies|
|Residue of Ignition||
|Sulphated Ash||≤ 0.1%||0.08%|
At 490nm ≤ 0.07
|Organic Impurities by HPLC||Cyproheptadine related compound C: ≤ 0.15%||Not detected|
|Amitriptyline related compound B ≤ 0.15%||Not detected|
|Cyproheptadine related compound A ≤ 0.15%||0.05%|
|Any individual unknown Impurity ≤ 0.1%||0.05%|
|Total impurities ≤0.5%||0.13%|
NMT 0.15 ml of 0.01 M sodium Hydroxide is
required to change the co lour of the indicator
|Water Determination||7.0% to 9.0%||8.5%|
|Residual Solvents||Methanol ≤300ppm||163ppm|
|O-rylene ≤2170ppm||Not detected|
|lsopropyl alcohol ≤5000ppm||24ppm|
|Toluene ≤890ppm||Not detected|
|Tetrahydrofuran ≤720ppm||Not detected|
|Chloroform ≤60ppm||Not detected|
|Assay (Dry based)||98.5%~100.5%||100.2%|
|Conclusion||Complies with the USP40 standard|