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Veterinary API CAS 57-62-5 Aureomycin Chlortetracycline HCL Powder 98%

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Chlortetracycline
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 57-62-5 Mf: C22H23ClN2O8
Melting Point: N/A Specification: ≥98%
Einecs No.: 200-341-7 Appearance: Yellow Powder
Whatsapp: +86152 029 61574
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Aureomycin Chlortetracycline HCL Powder


Veterinary Aureomycin Chlortetracycline HCL


Aureomycin HCL Veterinary API

Product Description

Veterinary API CAS 57-62-5 98% chlortetracycline HCL Powder

Veterinary API CAS 57-62-5 Aureomycin Chlortetracycline HCL Powder  98% 0


Prodcut name Chlortetracycline
CAS No. 57-62-5
Appearance Yellow Powder
Molecular Formula C22H23ClN2O8
Molecular Weight 523.563
Assay 99%
Application Pharma grade

Veterinary API CAS 57-62-5 Aureomycin Chlortetracycline HCL Powder  98% 1

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General Description

Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.

Purification Methods

Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.


The Introductction of Chlortetracycline :


Chlortetracycline is the 7-chloro substitution derivative of the tetracycline and has a golden color. As a veterinary medicine, chlortetracycline is commonly used for the treatment of conjunctivitis of cats. It can also be used in the treatment of infections occurring in the urinary tract, respiratory tract, and the intestines. Its mechanism of action is through inhibiting the protein synthesis, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex through binding to the 30S ribosome subunit.


The Application & Function of Chlortetracycline :

Chlortetracycline is used for purulent skin diseases such as impetigo, mild small burns and infections of ulcers.

Chlortetracycline has an inhibitory effect on both gram-positive and gram-negative bacteria, and can treat typhoid fever, pullorum and other diseases of livestock and poultry. At the same time, it can also be used as a growth promoter for pig feed. For broiler feed under 10 weeks of age, the dosage is 20-50g/t, with a withdrawal period of 7 days; for pig feed under 2 months of age, the dosage is 25-75g/t, with a withdrawal period of 7 days.


 The COA of Chlortetracycline :


Description Yellow powder Complies
Identification IR Complies
Test method HPLC Complies
Heavy metal ≤10ppm 5ppm
Pb ≤3ppm 1.5ppm
Hg ≤0.1ppm 0.05ppm
Cd ≤1ppm 0.2ppm
Loss on drying ≤0.5% 0.12
Residue on lgnition ≤0.1% 0.03
Single impurity ≤0.5% 0.12
Total impurity ≤1.0% 0.29
Total bacteria ≤1000cfu/g <1000
Yeast and Mould ≤100 cfu/g <000
E.coli/25g Absent Absent
Salmonella/25g Absent Absent
Assay ≥99.0% 99.4%
Conclusion Conforms with USP/EP standards

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