| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Chlortetracycline |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually7-10days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram |
| Supply Ability: | 5000kg/Month |
| CAS: | 57-62-5 | Mf: | C22H23ClN2O8 |
|---|---|---|---|
| Melting Point: | N/A | Specification: | ≥98% |
| Einecs No.: | 200-341-7 | Appearance: | Yellow Powder |
| Whatsapp: | +86152 029 61574 | ||
| High Light: | Aureomycin Chlortetracycline HCL Powder,Veterinary Aureomycin Chlortetracycline HCL,Aureomycin HCL Veterinary API |
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Veterinary API CAS 57-62-5 98% chlortetracycline HCL Powder
| Prodcut name | Chlortetracycline |
| MOQ | 1KG |
| CAS No. | 57-62-5 |
| Appearance | Yellow Powder |
| Molecular Formula | C22H23ClN2O8 |
| Molecular Weight | 523.563 |
| Assay | 99% |
| Application | Pharma grade |
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Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.
Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.
The Introductction of Chlortetracycline :
The Application & Function of Chlortetracycline :
Chlortetracycline is used for purulent skin diseases such as impetigo, mild small burns and infections of ulcers.
Chlortetracycline has an inhibitory effect on both gram-positive and gram-negative bacteria, and can treat typhoid fever, pullorum and other diseases of livestock and poultry. At the same time, it can also be used as a growth promoter for pig feed. For broiler feed under 10 weeks of age, the dosage is 20-50g/t, with a withdrawal period of 7 days; for pig feed under 2 months of age, the dosage is 25-75g/t, with a withdrawal period of 7 days.
The COA of Chlortetracycline :
| Description | Yellow powder | Complies |
| Identification | IR | Complies |
| Test method | HPLC | Complies |
| Heavy metal | ≤10ppm | 5ppm |
| Pb | ≤3ppm | 1.5ppm |
| Hg | ≤0.1ppm | 0.05ppm |
| Cd | ≤1ppm | 0.2ppm |
| Loss on drying | ≤0.5% | 0.12 |
| Residue on lgnition | ≤0.1% | 0.03 |
| Single impurity | ≤0.5% | 0.12 |
| Total impurity | ≤1.0% | 0.29 |
| Total bacteria | ≤1000cfu/g | <1000 |
| Yeast and Mould | ≤100 cfu/g | <000 |
| E.coli/25g | Absent | Absent |
| Salmonella/25g | Absent | Absent |
| Assay | ≥99.0% | 99.4% |
| Conclusion | Conforms with USP/EP standards | |
