Antipyretic Analgesic Pontocaine Tetracaine Hydrochloride Powder tetracaine

Antipyretic Analgesic Pontocaine Tetracaine Hydrochloride Powder tetracaine

The Introductction of Tetracaine hydrochloride

Tetracaine hydrochloride is a highly effective local anesthetic that reversibly blocks nerve function, and is clinically used for infiltration anesthesia, nerve block anesthesia, epidural anesthesia, and also for intradural block and nerve block, etc. Compared with procaine, its local anesthetic effect is remarkable and has been widely used in clinical practice.

Tetracaine hydrochloride is a long-acting ester local anesthetic, characterized by: strong penetration of mucous membrane, suitable for surface anesthesia, no vasoconstriction, pupil dilatation, corneal damage and other adverse reactions after dropping, commonly used in ophthalmology. The local anesthetic effect and toxicity are about 10 times greater than that of procaine. After injection, the anesthetic effect appears slowly (about 10 minutes), and metabolism is also slow after absorption, the local anesthetic time is up to 3IJ, H,-J. about. It is mainly used for surface anesthesia of eye, nose and throat mucosa, and rarely used for conduction anesthesia and epidural anesthesia. Because of high toxicity, it is generally not used for infiltration anesthesia.

Common methods of Tetracaine hydrochloride: surface local anesthesia, 1% solution sprayed or applied; infiltration local anesthesia, 0.025-0.03% solution; nerve block, 0.1-0.3% solution; epidural block 0.15-0.3% solution, the highest concentration is 0.3% when combined with lidocaine hydrochloride; subarachnoid block with 10-15 mg mixed with cerebrospinal fluid and injected. It should be noted that infiltration local anesthesia and nerve conduction block are the extreme amounts used 0.1g at a time.

Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.

The Application & Function of Tetracaine hydrochloride

Tetracaine hydrochloride used for mucosal surface anesthesia, conduction anesthesia, epidural anesthesia and subarachnoid anesthesia.
Tetracaine hydrochloride used for ophthalmic surface anesthesia without constricting blood vessels, without damaging the corneal epithelium, and without raising intraocular pressure.

Tetracaine topical (for the skin) is used to numb various body parts before a surgical procedure or a medical test. Conversely, tetracaine ophthalmic drops are used as local anesthetic for the eyes.

Other Name of Tetracaine hydrochloride:  

Tetracaine is used in assessing the potential for drug-nanoparticle surface interactions to improve drug penetration into the skin.

LANDOCAINHYDROCHLORIDE;INTERCAINHYDROCHLORIDE;MEETHOBALMHYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOICACID2-(DIMETHYLAMINO)ETHYLESTERHYDROCHLORIDE;4-[BUTYLAMINO]BENZOICACID-2-[DIChemicalbookMETHYLAMINO]ETHYLESTERHYDROCHLORIDE;4-BUTYLAMINOBENZOICACIDDIMETHYLAMINOETHYLESTERHCL;4-BUTYLAMINOBENZOICACIDDIMETHYLAMINOETHYLESTERHYDROCHLORIDE;AMETHOCAINEHYDROCHLORIDE

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The COA of Tetracaine hydrochloride