|Place of Origin:||China|
|Minimum Order Quantity:||10grams|
|Packaging Details:||1.1kg/bag;25kg/drum 2. Inside: steril plastic bag+aluminum foil bag Outside: carton/drum|
|Payment Terms:||T/T, Western Union,, L/C, D/A, D/P|
|Supply Ability:||10Metric tons per month|
|Product Name:||Vinpocetine||Appearance:||White Crystalline Powder|
|CAS No.:||42971-09-5||Molecular Formula:||C22H26N2O2|
|Shelf Life:||24months When Properly Stored||Purity:||99%min|
|HS Code:||2933990090||Function:||Peripheral Vasodilator|
|Storage Condition:||Keep Away From Heat, Open Flames And Sparks.|
Vinpocetine API Pharmaceutical Powder,
Circulatory System Peripheral Vasodilator Drugs
Circulatory system medication Peripheral vasodilator Vinpocetine Powder CAS 42971-09-5
Vinpocetine is a semisynthetic derivative of the alkaloid vincamine, an extract from the periwinkle plant.Vinpocetine is reported to have cerebral blood-flow enhancing and neuroprotective effects, and is usedas a drug in Eastern Europe for the treatment of cerebrovascular disorders and age-related memoryimpairment.It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.
1.Vinpocetine is chemically related to, and derived from vincamine, an alkaloid found in the periwinkle plant.
2. It was introduced into clinical practice in Europe more than two decades ago for its role in cerebrovascular disorders and related symptoms.
3.Experiments with this periwinkle extract indicate that it can dilate blood vessels, cross the blood-brain barrier, enhance circulation in the brain, improve oxygen utilization, make red blood cells more pliable, and inhibit aggregation of platelets.
4.Vinpocetine even has antioxidant properties. Levels peak in the bloodstream within an hour and a half after ingestion.
1.Applied in the food field, it has become a new raw material which used in food and beverage industry;
2.Applied in the health product field;
3.Applied in the pharmaceutical field.
Product analysis report
|Test sample: 1gram Sample base: 5gram|
|Manufacture Date: 1st Nov,2022 Analysis Date: 1st Nov, 2022|
|Storage: Store in cool & dry place, in well-closed containers.|
|Shelf life: 24 Months when properly stored.|
|ITEMS OF ANALYSIS||SPECIFICATIONS||RESULT|
White crystalline or slightly crystalline powder
|White crystalline powder|
|Solubility||Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrousethanol||Complies|
|Identification (IR)||Same wave numbers as that of the Vinpocetine, CRS similarly prepared||Complies|
|Specific Optical Rotation (On dried basis)||Between +127°and +134°||+132.7°|
|Residue on ignition||≤0.10%||0.04%|
|Loss on drying||≤0.5%||0.04%|
|Related Substances||Ethyl vincaminate(A) ≤0.6%||Complies|
|Methoxyvinpocetine(C) ≤0.3%||Not detected|
|Dihydrovinpocetine(D) ≤0.5%||Not detected|
|Other single impurity ≤0.10%||Complies|
|Total impurity ≤1.0%||0.19%|
|Assay||98.0~102.0% (Calculated on anhydrous basis)||99.4%|
|Conclusion||The above material complies with USP38|
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