CAS: | 59703-84-3 | Mf: | C23H26N5NaO7S |
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MW: | 539.54 | Specification: | ≥98% |
Appearance: | White Crystalline Powder | Product Name: | Piperacillin Sodium Tazobactam Sodium |
High Light: | 59703-84-3 Piperacillin Sodium Tazobactam Sodium,Inflammatory Disease Piperacillin Sodium Tazobactam Sodium,CAS 59703-84-3 tazobactam sodium sterile |
CAS 59703-84-3 API Raw Material Antibiotic Piperacillin Sodium Tazobactam Sodium
Fp | 27°C |
storage temp. | Flammables area |
form | Powder |
color | White to off-white |
Water Solubility | soluble |
Merck | 14,5956 |
BRN | 3592983 |
InChIKey | RMBAVIFYHOYIFM-UHFFFAOYSA-M |
CAS DataBase Reference | 5188-07-8(CAS DataBase Reference) |
EPA Substance Registry System | Methanethiol, sodium salt (5188-07-8) |
The Introductction
Piperacillin, chemical name (2S, 5R, 6R)- 3,3- dimethyl- 6- [(R) -2- (4- ethyl- 2,3- dioxo-1- piperazinyl amino) -2- Phenylacetylamino]- 7- oxo- 4 -thiohetero -1 -azabicyclo [3.2.0] heptane -2 -carbamic acid monohydrate, is a semi synthetic penicillin antibiotic with broad-spectrum antibacterial effect. Piperacillin is a penicillin broad-spectrum antibiotic. It mainly plays a bactericidal role by interfering with the synthesis of bacterial cell wall. It is mainly used for the infection caused by Pseudomonas aeruginosa and various gram-negative bacilli, but it is easy to be produced by bacteria β- Lactamase hydrolysis and drug resistance; Sulbactam has no antibacterial activity against other bacteria except Neisseria and Acinetobacter β-Lactam resistant strains produce most important antibiotics β- Lactamase has irreversible inhibition.
The Application & Function
Treatment of postpartum endometritis or pelvic inflammatory disease (PID) caused by β-lactamase-producing Escherichia coli resistant to piperacillin but susceptible to piperacillin and tazobactam.
Treatment of appendicitis (complicated by rupture or abscess) and peritonitis caused by β-lactamase-producing E. coliresistant to piperacillin but susceptible to piperacillin and tazobactam or caused by Bacteroides fragilis, B. ovatus, B. thetaiotaomicron, or B. vulgatus.
Treatment of moderately severe community-acquired pneumonia (CAP) caused by β-lactamase-producing Haemophilus influenzae resistant to piperacillin but susceptible to piperacillin and tazobactam
The COA
Item | Specifications | Results |
Appearance | A white crystalline powder |
white crystalline powder |
Identification | A.The solution appears purple | Conforms |
B.IR:consistent with the spectrum obtained with .Rimantadine Hydrochloride RS |
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C.Specific Reaction of chloride | ||
PH | 4.5-6.5(1% solution in water) | 4.93 |
Clarity of solution |
Solution of substance must stand the comparison with etalon I |
Conforms |
Color of solution |
Color of solution must stand the comparison with etalon Y7 |
Conforms |
Sulphates | NMT0.05% | Conforms |
Toluene | NMT890ppm | Not detected |
Methanol | NMT3000ppm | Not detected |
Related substances (TLC) |
NMT1.0% | Conforms |
Loss on drying | NMT0.5% | 0.07% |
Sulphated ash | NMT0.1% | 0.09% |
Ammonium | NMT0.08% | Conforms |
Heavy metals | NMT0.001% | Conforms |
Assay(On dry basis) | 99.0%-101.0% | 99.58% |
Solubility |
Freely Soluble in Chloroform and methanol, soluble in 95% ethanol an water. |
Conforms |
Microbiology | Total bacterial count:<1000CFU/g | 30CFU/g |
Total Fungus count: <100CFU/g | <10 CFU/g | |
Escherichia coli:Not detected | Not detected | |
Conclusion |
The results conforms with Russian Registration Specification. |