| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Candesartan cilexetil |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually7-10days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram |
| Supply Ability: | 5000kg/Month |
| CAS: | 145040-37-5 | Mf: | C33H34N6O6 |
|---|---|---|---|
| MW: | 610.660 | Specification: | ≥98% |
| Einecs No.: | N/A | Appearance: | White Powder |
CAS 145040-37-5 Circulatory system medication Anti hypertensive drug Candesartan cilexetil Powder
|
Product Name |
Candesartan cilexetil |
|
Function |
APIs |
|
Specification |
99%Tech |
|
Chemical Name |
1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate |
|
CAS No. |
145040-37-5 |
|
Empirical Formula |
C33H34N6O6 |
|
Toxicology |
Corrosion or irritation to skin: no data available |
|
Applications |
Candesartan Cilexetil (TCV-116) is an angiotensin II antagonist used in hypertension. |
|
Package |
1kg/bag,25kg/drum |
The Introductction of Candesartan cilexetil:
Candesartan ester is an organic compound with the molecular formula C33H34N6O6. This product is white and sweet. It is rapidly broken down in the body into the active metabolite Candesartan. Candesartan is an angiotensin ⅱ AT receptor antagonist, which antagonizes angiotensin ⅱ contraction by binding to the vascular smooth muscle AT receptor, thereby reducing peripheral vascular resistance. Suitable for essential hypertension.
The Application & Function of Candesartan cilexetil:
Candesartan is rapidly hydrolyzed into the active metabolite candesartan in vivo. Candesartan is a selective angiotensin ⅱ receptor (ATl) antagonist, which antagonizes angiotensin ⅱ vasoconstriction by binding to vascular smooth muscle ATl receptor, thereby reducing peripheral vascular resistance. It was also suggested that candesartan could inhibit the secretion of aldosterone by adrenal gland and play a certain antihypertensive role. Candesartan did not inhibit kalinin ii and did not affect bradykinin degradation.
Application:
Candesartan ester is the precursor of candesartan, which is rapidly and completely hydrolyzed to candesartan during absorption by the gastrointestinal tract. The absolute bioavailability of Candesartan is about 15%, and the peak time of plasma candesartan concentration is 3-4 hours. The binding rate of candesartan to plasma protein was greater than 99% and the apparent volume of distribution was 0.13L/kg. Studies in rats have shown that candesartan rarely crosses the blood-brain barrier, but can cross the placental barrier and distribute to the fetus.
Candesartan is mainly excreted in urine and feces in its original form, and very little of it is excreted in liver by O-deethylation reaction to produce inactive metabolites. The excretory half-life of Candesartan is about 9 hours. The plasma clearance rate of Candesartan was 14.07L/h and the half-life of terminal elimination was 9-L3 hours in patients with hypertension who took it orally 2-L 6mg/ day for 4 weeks. Data showed that the total clearance rate of Candesartan was 0.37 mL /min·kg, and the renal clearance rate was 0.19ml. After oral administration of 14C-labeled Candesartan ester, 33% and 67% of radioactive substances were recovered from urine and feces, respectively.
The COA of Candesartan cilexetil
| Inspection Items | Standard | Inspection Result | Conclusion |
| Description | White or off-white powder | Off-white powder | Conforms |
| Identification | IR | Conforms | Conforms |
| Loss on drying | ≤0.3% | 0.16% | Qualified |
| Residue on ignition | ≤0.1% | 0.06% | Qualified |
| Single impurity | ≤0.5% | 0.23% | Qualified |
| Total impurities | ≤1.0% | 0.57% | Qualified |
| Purity(HPLC) | ≥99.0% | 99.43% | Qualified |
| Conclusion | According with the standard, it conformed. | ||
