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CAS 145040-37-5 Circulatory system medication Anti hypertensive drug Candesartan cilexetil Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Candesartan cilexetil
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 145040-37-5 Mf: C33H34N6O6
MW: 610.660 Specification: ≥98%
Einecs No.: N/A Appearance: White Powder

Product Description

CAS 145040-37-5 Circulatory system medication Anti hypertensive drug Candesartan cilexetil Powder

CAS 145040-37-5 Circulatory system medication Anti hypertensive drug Candesartan cilexetil Powder 0

Product Name

Candesartan cilexetil

Function

APIs

Specification

99%Tech

Chemical Name

1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate

CAS No.

145040-37-5

Empirical Formula

C33H34N6O6

Toxicology

Corrosion or irritation to skin: no data available
Severe eye damage or irritation: no data available
Germ cell mutagenicity: no data available
Carcinogenicity:
IARC = No data
NTP = No data
Reproductive toxicity: no data available

Applications

Candesartan Cilexetil (TCV-116) is an angiotensin II antagonist used in hypertension.

Package

1kg/bag,25kg/drum

 

The Introductction of Candesartan cilexetil:

 

Candesartan ester is an organic compound with the molecular formula C33H34N6O6. This product is white and sweet. It is rapidly broken down in the body into the active metabolite Candesartan. Candesartan is an angiotensin ⅱ AT receptor antagonist, which antagonizes angiotensin ⅱ contraction by binding to the vascular smooth muscle AT receptor, thereby reducing peripheral vascular resistance. Suitable for essential hypertension.

 

The Application & Function of Candesartan cilexetil:

 

Candesartan is rapidly hydrolyzed into the active metabolite candesartan in vivo. Candesartan is a selective angiotensin ⅱ receptor (ATl) antagonist, which antagonizes angiotensin ⅱ vasoconstriction by binding to vascular smooth muscle ATl receptor, thereby reducing peripheral vascular resistance. It was also suggested that candesartan could inhibit the secretion of aldosterone by adrenal gland and play a certain antihypertensive role. Candesartan did not inhibit kalinin ii and did not affect bradykinin degradation.

 

Application:

 

Candesartan ester is the precursor of candesartan, which is rapidly and completely hydrolyzed to candesartan during absorption by the gastrointestinal tract. The absolute bioavailability of Candesartan is about 15%, and the peak time of plasma candesartan concentration is 3-4 hours. The binding rate of candesartan to plasma protein was greater than 99% and the apparent volume of distribution was 0.13L/kg. Studies in rats have shown that candesartan rarely crosses the blood-brain barrier, but can cross the placental barrier and distribute to the fetus.
Candesartan is mainly excreted in urine and feces in its original form, and very little of it is excreted in liver by O-deethylation reaction to produce inactive metabolites. The excretory half-life of Candesartan is about 9 hours. The plasma clearance rate of Candesartan was 14.07L/h and the half-life of terminal elimination was 9-L3 hours in patients with hypertension who took it orally 2-L 6mg/ day for 4 weeks. Data showed that the total clearance rate of Candesartan was 0.37 mL /min·kg, and the renal clearance rate was 0.19ml. After oral administration of 14C-labeled Candesartan ester, 33% and 67% of radioactive substances were recovered from urine and feces, respectively.

 

 

The COA of Candesartan cilexetil

 

Inspection Items Standard Inspection Result Conclusion
Description White or off-white powder Off-white powder Conforms
Identification IR Conforms Conforms
Loss on drying ≤0.3% 0.16% Qualified
Residue on ignition ≤0.1% 0.06% Qualified
Single impurity ≤0.5% 0.23% Qualified
Total impurities ≤1.0% 0.57% Qualified
Purity(HPLC) ≥99.0% 99.43% Qualified
Conclusion According with the standard, it conformed.

 

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