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CAS 66085-59-4 Circulatory system medication Prevention and treatment of angina pectoris Nimodipine Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Rosuvastatin
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 66085-59-4 Mf: C21H26N2O7
MW: 418.440 Specification: ≥98%
Einecs No.: N/A Appearance: Yellow Crystalline Powder

Product Description

CAS 66085-59-4 Circulatory system medication Prevention and treatment of angina pectoris Nimodipine Powder

CAS 66085-59-4 Circulatory system medication Prevention and treatment of angina pectoris Nimodipine Powder 0

Product Name






Chemical Name

1-methylethyl 2-(methyloxy)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate



Empirical Formula



LD50 mouse, rat (mg/kg) : 3526,6599; 33.16 Intravenous injection.


Nimodipine is a calcium channel blocker nifedipine analogue that decreases blood pressure, intracellular free calcium, Beclin-1, and autophagy.




The Introductction of Rosuvastatin:


Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.Target: Calcium ChannelNimodipine is main use is in the prevention of cerebral vasospasm and resultant ischemia, a complication of subarachnoid hemorrhage (a form of cerebral bleed), specifically from ruptured intracranial berry aneurysms irrespective of the patient's post-ictus neurological condition. Its administration begins within 4 days of a subarachnoid hemorrhage and is continued for three weeks. If blood pressure drops by over 5%, dosage is adjusted. There is still controversy regarding the use of intravenous nimodipine on a routine basis


The Application & Function of Rosuvastatin:


① Improvement of blood circulation during convalescence of acute cerebrovascular disease. Cerebral vasospasm after various causes of subarachnoid hemorrhage, and its caused by ischemic nerve disorders, hypertension, migraine and so on. ② It is also used as a treatment for ischemic neuron protection and vascular dementia. ③ It is also effective for sudden deafness.




Nimodipine is a calcium antagonist of dihydropyridine, and its effect is similar to nifedipine, but it is weaker than nifedipine. Nimodipine is a calcium antagonist selectively acting on the cerebrovascular smooth muscle, acting on the cerebrovascular smooth muscle, fat soluble, easily through the blood-cerebrospinal fluid barrier, binding with the specific receptors of the central nervous system, expanding the cerebrovascular, increasing cerebral blood flow, and antagonizing 5-HT, arachidonic acid, TXA2 caused by cerebral vasospasm. It can effectively prevent or reverse ischemic damage of brain tissue caused by cerebral vasospasm caused by subarachnoid hemorrhage in experimental dogs. It has little effect on peripheral blood vessels and has protective effect on ischemic brain injury, especially on ischemic cerebral vasospasm. Nimodipine can simultaneously increase coronary blood flow and lower blood pressure with increased dose, but does not decrease cerebral blood flow while lowering blood pressure. Nimodipine has a direct effect on neurons, changes the function of neurons, has neurological and psychopharmacologic activities, animal experiments have shown that it can improve memory disorders caused by hypoxia and electroshock. There are anti-depression and improve consciousness and memory function, the effect of senile depression is especially good, promote wisdom than piracetam and vinblamide, respectively, 60 and 1000 times stronger. At the same time, it can prevent intracellular Ca influx in cerebral infarction area and reduce cerebral infarction area. It is also reported that nimodipine can block or prevent the interaction and aggregation of tumor cells and platelets, significantly reduce the metabolism of cancer cells and prevent the spread of cancer cells. Recent data show that it can protect and promote memory and restore intelligence.



The COA of Rosuvastatin


Items Standard Results
APPEARANCE White to yellow powder Yellow powder
B: Retention time
WATER 0.5% 0.06%
HEAVY METALS ≤0.002% Complies
ISOMERS SFBD1≤0.15% Undetected
  SFBD2≤0.15% Undetected
  SFBE≤0.15% Undetected
  SFBMA≤0.15% Undetected
  CHLORO-SFB≤0.15% 0.05%
  DiSFBMA-SFB≤0.15% 0.02%
  Methyl-SFB≤0.15% Undetected
  Pentafluoro-phenol≤0.15% Undetected
  Amino-SFB≤0.15% Undetected
  Any unknown impurity≤0.1% 0.04%
  Total impurity≤1.0% 0.21%
RESIDUE SOLBENTS Methanol≤3000ppm Undetected
  Isopropyl alcohol≤5000ppm 19ppm
  Dichloromethane≤600ppm Undetected
  Tetrahydrofuran≤720ppm Undetected
  Acetic acid≤5000ppm Undetected
  Toluene≤890ppm Undetected
  Chlorobenzene≤360ppm Undetected
  Methyl tert-butyl ether≤5000ppm 103ppm
ASSAY ≥99.0% 99.8%


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