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CAS 74150-27-9 PDE inhibitor Cardiotonic Drug Pimobendan Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Pimobendan
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, , MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 74150-27-9 Mf: C19H18N4O2
MW: 334.372 Specification: ≥98%
Einecs No.: N/A Appearance: White Crystalline Powder

Product Description

CAS 74150-27-9 PDE inhibitor Cardiotonic Drug Pimobendan Powder

CAS 74150-27-9 PDE inhibitor Cardiotonic Drug Pimobendan Powder 0

Product Name

Pimobendan

Function

APIs

Specification

99%Tech

Chemical Name

(RS)-6-[2-(4)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one

CAS No.

74150-27-9

Empirical Formula

C19H18N4O2

Toxicology

Details of toxic effects not reported other than lethal dose value

Applications

Pimobendam is a chemical used to treat mild, moderate, or severe congestive heart failure caused by atrioventricular insufficiency or cardiac hypertrophy in dogs.

Package

1kg/bag,25kg/drum

 

The Introductction of Pimobendan:

 

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.Target: PDE3Pimobendan exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). In human atrial cells, 100 μM pimobendan significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC50) of 1.13 μM. In rabbit atrial cells, Pimobendan increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells Pimobendan shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis.

 

The Application & Function of Pimobendan:

 

Pimobendam is a chemical used to treat mild, moderate, or severe congestive heart failure caused by atrioventricular insufficiency or cardiac hypertrophy in dogs.

 

Application:

 

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.Target: PDE3Pimobendan exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). In human atrial cells, 100 μM pimobendan significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC50) of 1.13 μM. In rabbit atrial cells, Pimobendan increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells Pimobendan shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis.

 

The COA of Pimobendan

 

Item Specifications Results
Appearance White crystalline Powder Confirms
solubility Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in aceton and in methano. Conforms
Identification Infrared absorption spectrophotometry , Comparison pimobendan CRS Conforms
Heavy metals ≤10ppm 1ppm
Water ≤1.0% 0. 1%
Assay (HPLC) 98.0%~100.0% 99.83%
Sulphated ash ≤0.1% 0.01%
Related substances(HPLC) Impurity A:≤0.1% 0.03%
  Impurity B:≤0.1% 0.07%
  Any other impurity:≤0.1% 0.05%
  Total impurity:≤0.2% 0.17%
Conclusion The results conforms with Enterprise standards  

 

Contact Details
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