CAS 104344-23-2 Circulatory system medication Antiarrhythmic drug Bisoprolol Fumarate Powder

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Bisoprolol Fumarate
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 104344-23-2 Mf: C40H66N2O12
MW: 766.96 Specification: ≥98%
Einecs No.: N/A Appearance: White Powder

Product Description

CAS 104344-23-2 Circulatory system medication Antiarrhythmic drug Bisoprolol Fumarate Powder

CAS 104344-23-2 Circulatory system medication Antiarrhythmic drug Bisoprolol Fumarate Powder 0

Product Name

Bisoprolol Fumarate





Chemical Name

1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)



Empirical Formula



Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold


Bisoprolol is a β1 adrenergic receptor blocker




The Introductction of Bisoprolol Fumarate:


Bisoprolol is a selective type β1 adrenergic receptor blocker.Target: Adrenergic ReceptorApproved: July 31, 1992Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol.


The Application & Function of Bisoprolol Fumarate:


Hypertension, coronary heart disease (angina).Moderate to severe chronic stable heart failure with reduced ventricular systolic function (ejection fraction 35%, determined by echocardiography). Prior to use, ACE inhibitors, diuretics, and selective cardiac glycosides should be prescribed.




Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) [2].Toxicity: Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.



The COA of ​Bisoprolol Fumarate


Description White Or Almost White Crystalline Powder White Powder
Identification Infrared Absorption Positive
Assay 97.0~103.0% 99.2%
Melting Point 33~37ºC 34.5~36.5ºC
Loss On Drying 0.5%max 0.30%
Organic Volatile Impurities 2500PPm max <1000PPm
Residual Solvents Meet the requirements.(USP29) Confirms
Chromatographic purity sum of impurities:3.0%max <3.0%
Conclusion The specification conform with USP32 standard


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