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Antibiotic Chloramphenicol for Enterobacteriaceae and Bacillus anthracis

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO
Model Number: Chloramphenicol
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Aluminum foil bag
Delivery Time: Usually7-10days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 56-75-7 Mf: C11H12Cl2N2O5
MW: 323.13 Specification: ≥98%
Einecs No.: 200-287-4 Appearance: A Yellowsh-white, Fine Crystalline Powder
Key Word: Chloramphenicol Application: Medicine
Storage: Cool And Dry Place
High Light:

CAS 56-75-7 Antibiotic API

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Antibiotic API Chloramphenicol

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CAS 56-75-7 Chloramphenicol powder


Product Description

   CAS 56-75-7 Antibiotic API Antibacterial Chloramphenicol powder

Antibiotic Chloramphenicol for Enterobacteriaceae and Bacillus anthracis 0

 

Product name

Chloramphenicol

Cas number

56-75-7

Apperance

White crystalline powder

Density

1.547

MF

C11H12Cl2N2O5

Refractive index

20 ° (C=5, EtOH)

Boiling point

644.9 oC at 760 mmHg

 

The Introductction of Chloramphenicol:

 

Chloramphenicol is a broad-spectrum antibiotic.Target: AntibacterialChloramphenicol is a bacteriostatic drug that stops bacterial growth by inhibiting protein synthesis. Chloramphenicol prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation. While chloramphenicol and the macrolide class of antibiotics both interact with ribosomes, chloramphenicol is not a macrolide. It directly interferes with substrate binding, whereas macrolides sterically block the progression of the growing peptide.

 

The Application & Function of Chloramphenicol:

 

Chloramphenicol is used for the treatment of serious infections when the microorganism is resistant to less toxic antibiotics and also when its ability to penetrate to the site of the infection is superior to less toxic alternative antibiotics.
Chloramphenicol is used only when safer drugs are contraindicated; pregnancy,lactation,or known hypersensitivity to this drug also prohibits its use.

 

Function of Chloramphenicol:

Chloramphenicol is effective against a wide variety of Gram-positive and Gram-negative bacteria, including most anaerobic organisms. Due to resistance and safety concerns, it is no longer a first-line agent for any indication in developed nations, although it is sometimes used topically for eye infections; nevertheless, the global problem of advancing bacterial resistance to newer drugs has led to renewed interest in its use. In low-income countries, chloramphenicol is still widely used because it is exceedingly inexpensive and readily available.

 

 The COA of Chloramphenicol:

 

Product name

Chloramphenicol

Standard

BP2019 / EP9.0

Batch No.

20210302

MFG. Date

MAR. 02, 2021

Report Date

MAR. 03, 2021

Batch size

3000KGS

EXP. Date

MAR. 01, 2026

Packing

25kg/drum

Appearance

A while, greyish-white or yellowish-white, fine, crystalline powder or fine crystals, needles or elongated plates.

A yellowsh-white, fine
crystalline powder, needles

Solubility

Slightly soluble in water, freely soluble in alcohol and in propylene glycol. Its alcohol solution is dextrorotatory and its ethyl acetate solution is levorotatory.

Qualified

Identification

Melting range

149°C ~153°C

151~152°C

Infrared absorption spectrophotometry

IR spectrophotometry similar to which of Chloramphenicol CRS

Qualified

Acidity or alkalinity

To 0.1g add 20 ml of carbon dioxide-free water R, shake and add 0.1 ml of bromothymol blue solution Rl. Not more than0.1 ml of 0.02 M hydrochloric acid or 0. 02 M sodium hydroxide is required to
change the colour of the indicator.

Qualified

Specific optical rotation

+18.5°~20.5°

+19.8°

Related substances

Individaul impurity ≤ 0.5%

0.31%

Chorides

≤0.01%

<0.01%

Loss on drying

≤0.3%

0.18%

Sulfated ash

≤0.1%

0.06%

Assay

98.0%~102.0%

99.4%

Microbial limit

Total aerobic microbial count

≤10CFU/g

<10CFU/g

Total yeasts and molds count

Absent per g

Absent

Escherichia coli

Absent per g

Absent

Pseudomonas aeruginosa & staphylococcus aureus

Absent per g

Absent

Conclusion

The product complies to BP2019 / EP9.0

Packaging and storage

Preserve in well-closed containers, protected from light.

 

Antibiotic Chloramphenicol for Enterobacteriaceae and Bacillus anthracis 1Antibiotic Chloramphenicol for Enterobacteriaceae and Bacillus anthracis 2

  

Contact Details
Eric Tong

Phone Number : +8618220855851

WhatsApp : +8618629242069