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API Anti Allergy Powder CAS 113-92-8 Chlorpheniramine Maleate

Basic Information
Place of Origin: China
Brand Name: HNB
Certification: ISO, SGS
Model Number: Chlorpheniramine Maleate
Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Carton Box or Drum
Delivery Time: Usually7-10days
Payment Terms: L/C, D/P, D/A, T/T, Western Union, MoneyGram
Supply Ability: 5000kg/Month
Detail Information
CAS: 113-92-8 Mf: C20h23cln2o4
MW: 390.86 Einecs: 204-037-5
Specification: 98% Certificate: GMP/ISO9001
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API Anti Allergy Powder

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Anti Allergy Powder Chlorpheniramine Maleate

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CAS 113-92-8 API Drug


Product Description

CAS 113-92-8 API Antiallergic drugs Chlorpheniramine Maleate

API Anti Allergy Powder CAS 113-92-8 Chlorpheniramine Maleate 0

 

Product Name

Chlorphenamine Maleate

Synonyms

1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate;1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate;2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1);Chlorophenamine;Chlorprophenpyridamine maleate;Cloropiril;Histadur

CAS NO

113-92-8

EINECS

204-037-5

Molecular Formula

C20H23ClN2O4

Molecular Weight

390.86

Melting Point

130-135 °C (lit.)

Boiling Point

N/A

Flash Point

9ºC

Density

1.1984 (rough estimate)

Assay

≥99%

Grade

Pharmaceutical Grade

Solubility

Freely soluble in water, soluble in ethanol (96 per cent)

Appearance

White Solid

Storage

2-8°C

Usage

Chlorpheniramine Maleate is an antagonist of the histamine H1-receptor

 

 

The Introductction of Chlorphenamine Maleate

 

Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an is chemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.

 

 

The Function&Application of Chlorphenamine Maleate

 

 

Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.

This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms.

 

The COA of Chlorphenamine Maleate

 

 

Testing Items

Specifications

Test Results

Appearance

White crystalline powder

Confirm

Identification

IR:should be consistent with the IR references spectrum.

Conform

Solubility

Easily soluble in water, ethanol or chlorofor, slightly soluble in ether.

Confirm

Loss on drying

0.5%

0.10%

Residue on ignition

≤ 0.1%

0.01%

PH

4.0~5.0

4.6

Assay

98.5%-102.0%

99.8%

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